ARDS

Respiratory

Unlocking the power of biomarkers: transforming the diagnosis of acute respiratory distress syndrome

Abstract Acute respiratory distress syndrome (ARDS) remains a significant challenge due to its heterogeneity and lack of targeted therapies. Recent advances in biomarkers offer promise in refining diagnosis, assessing severity, and personalizing treatment strategies. This article explores the evolving role of biomarkers in ARDS, highlighting their potential to enhance clinical precision, differentiate subphenotypes, and guide […]

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Respiratory

Effect of emodin on acute lung injury: a meta-analysis of preclinical trials

Abstract Background Emodin has protective effects on acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). This meta-analysis intended to illustrate the efficacy of emodin on ALI/ARDS animal models. Methods Relevant preclinical studies were searched on PubMed, EMBASE, and Web of Science. Standardized mean differences (SMDs) with corresponding confidence intervals (CIs) were used to

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Respiratory

Challenges in Transitioning from Controlled to Assisted Ventilation in Acute Respiratory Distress Syndrome (ARDS) Management

Abstract Acute respiratory distress syndrome (ARDS) presents significant challenges in critical care, primarily due to its inflammatory nature, which leads to impaired gas exchange and respiratory mechanics. While mechanical ventilation (MV) is essential for patient support, the transition from controlled to assisted ventilation is complex and may be associated with intensive care unit-acquired weakness, ventilator-induced

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Circulatory

Anticoagulation management during veno-venous ECMO support because of ARDS: Single-center experience

Abstract   Background Patients with severe acute respiratory distress syndrome (ARDS) show a high mortality rate of up to 60 %. In such cases, extracorporeal membrane oxygenation (ECMO) support is often required, which would necessitate anticoagulation therapy, predominantly with heparin. Some bleeding events occurred more frequently in patients during the COVID-19 pandemic who were on venovenous

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Anticoagulation management during veno-venous ECMO support because of ARDS: Single-center experience Read Post »

Circulatory

ECMO-weaning facilitated by neurally adjusted ventilatory assist (NAVA): a case for principal clarification

Abstract The use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) has become increasingly prevalent, particularly in respiratory disease pandemics such as H1N1-influenza and SARS-CoV-2. This surge has emphasized the importance of clear therapy recommendations, improved accessibility to ECMO technology, established ECMO teams, and structured networks to ensure access to specialized care throughout the course of the

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ECMO-weaning facilitated by neurally adjusted ventilatory assist (NAVA): a case for principal clarification Read Post »

Respiratory

Gattinoni’s Legacy: Personalizing ARDS Management Through Physiology

While writing this editorial, we learned that Professor Luciano Gattinoni—a giant in our field—had passed away. “Giant” seems an inadequate descriptor for a physician-scientist whose profound insights have fundamentally reshaped our understanding of critical care in general, and of acute respiratory distress syndrome (ARDS) in particular. His enduring legacy will continue to impact researchers, clinicians,

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Mechanical Ventilation, Respiratory

Personalized mechanical ventilation in acute respiratory distress syndrome

Abstract A personalized mechanical ventilation approach for patients with adult respiratory distress syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging, and biological phenotypes may improve ventilation practice and outcome. However, additional research is warranted before personalized mechanical ventilation strategies can be applied at the bedside. Ventilatory parameters should be titrated based

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Respiratory

The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned?

Summary of “The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned?” Abstract Summary: The COVID-19 pandemic has expanded our understanding of acute respiratory distress syndrome (ARDS), revealing unique pathophysiological characteristics of COVID-19 ARDS. Distinct features include severe hypoxemia, vascular injury, and microthrombosis, often disproportionate to respiratory compliance. These findings challenge conventional ARDS management strategies,

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Mechanical Ventilation

Ventilator induced lung injury: a case for a larger umbrella?

Summary of “Assessing lung recruitability: does it help with PEEP settings?” This editorial examines the relationship between lung recruitability and the selection of positive end-expiratory pressure (PEEP) settings in acute respiratory distress syndrome (ARDS) management. While recruitability measures the potential to reinflate atelectatic lung regions, PEEP must prevent their collapse while considering additional factors like

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