ARDS

Circulatory, Respiratory

Managing Refractory Hypoxemia in ARDS Obese Patients with Veno-Venous Extra-Corporeal Membrane Oxygenation: A Narrative Review

Abstract Veno-venous extracorporeal membrane oxygenation (vvECMO) is a life-saving intervention for severe respiratory failure unresponsive to conventional therapies. However, managing refractory hypoxemia in morbidly obese patients poses significant challenges due to the unique physiological characteristics of this population, including hyperdynamic circulation, elevated cardiac output, and increased oxygen consumption. These factors can limit the effectiveness of […]

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Managing Refractory Hypoxemia in ARDS Obese Patients with Veno-Venous Extra-Corporeal Membrane Oxygenation: A Narrative Review Read Post »

Mechanical Ventilation

Navigating Heart–Lung Interactions in Mechanical Ventilation: Pathophysiology, Diagnosis, and Advanced Management Strategies in ARDS and Beyond

Abstract Patients in critical condition who require mechanical ventilation experience intricate interactions between their respiratory and cardiovascular systems. These complex interactions are crucial for clinicians to understand as they can significantly influence therapeutic decisions and patient outcomes. A deep understanding of heart–lung interactions is essential, particularly under the stress of mechanical ventilation, where the right

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Navigating Heart–Lung Interactions in Mechanical Ventilation: Pathophysiology, Diagnosis, and Advanced Management Strategies in ARDS and Beyond Read Post »

Pharmacological Insights in Critical Care

Inhaled Sedation in Acute Respiratory Distress Syndrome. The SESAR Randomized Clinical Trial

Summary of “Inhaled Sedation in Acute Respiratory Distress Syndrome: The SESAR Randomized Clinical Trial” Abstract This randomized clinical trial compared the efficacy and safety of inhaled sevoflurane versus intravenous propofol for sedation in patients with moderate to severe acute respiratory distress syndrome (ARDS). Conducted across 37 French ICUs, the study enrolled 687 patients to determine

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Inhaled Sedation in Acute Respiratory Distress Syndrome. The SESAR Randomized Clinical Trial Read Post »

Respiratory

Electrical impedance tomography-guided the optimal awake prone position in a moderate ARDS patient

Awake prone positioning (APP) has gained prominence as a therapeutic intervention for acute respiratory distress syndrome (ARDS), particularly in COVID-19-related respiratory failure due to its proven survival benefits [1, 2]. However, the clinical applicability of APP in non-COVID-19 ARDS populations remains controversial, with patient tolerance and heterogeneous lung recruitment responses posing significant challenges [3]. To address

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Electrical impedance tomography-guided the optimal awake prone position in a moderate ARDS patient Read Post »

Mechanical Ventilation

Inconsistent Methods Used to Set Airway Pressure Release Ventilation in ARDS: A Systematic Review and Meta-Regression Analysis

Abstract Airway pressure release ventilation (APRV) is a protective mechanical ventilation mode for patients with acute respiratory distress syndrome (ARDS) that theoretically may reduce ventilator-induced lung injury (VILI) and ARDS-related mortality. However, there is no standard method to set and adjust the APRV mode shown to be optimal. Therefore, we performed a meta-regression analysis to

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Inconsistent Methods Used to Set Airway Pressure Release Ventilation in ARDS: A Systematic Review and Meta-Regression Analysis Read Post »

Pulmonary

ARDS Subphenotypes Exhibit Different Right Ventricular-Pulmonary Arterial Coupling Profiles

Summary of “ARDS Subphenotypes Exhibit Different Right Ventricular-Pulmonary Arterial Coupling Profiles” Abstract Acute respiratory distress syndrome (ARDS) is a heterogeneous condition with distinct subphenotypes that exhibit different responses to interventions. Right ventricular-pulmonary arterial (RV-PA) coupling, a key determinant of cardiopulmonary interactions in ARDS, has not been well studied across subphenotypes. This study analyzed RV-PA coupling

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ARDS Subphenotypes Exhibit Different Right Ventricular-Pulmonary Arterial Coupling Profiles Read Post »

Mechanical Ventilation

Double cycling with breath-stacking during partial support ventilation in ARDS: Just a feature of natural variability?

Abstract Background Double cycling with breath-stacking (DC/BS) during controlled mechanical ventilation is considered potentially injurious, reflecting a high respiratory drive. During partial ventilatory support, its occurrence might be attributable to physiological variability of breathing patterns, reflecting the response of the mode without carrying specific risks. Methods This secondary analysis of a crossover study evaluated DC/BS

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Double cycling with breath-stacking during partial support ventilation in ARDS: Just a feature of natural variability? Read Post »

Respiratory

Pneumomediastinum and pneumothorax in acute respiratory distress syndrome (ARDS) patients: a narrative review

Abstract Background and Objective: Acute respiratory distress syndrome (ARDS) is a severe, life-threatening medical condition characterized by poor oxygenation due to non-compliant lungs secondary diffuse alveolar damage. Encouragingly, the incidence of ARDS has declined steadily recently, attributed mainly to implementation of keystone guidelines and continuous research efforts. Mechanical ventilation is the cornerstone of supportive care for

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Pneumomediastinum and pneumothorax in acute respiratory distress syndrome (ARDS) patients: a narrative review Read Post »

Respiratory

A narrative review on the future of ARDS: evolving definitions, pathophysiology, and tailored management

Abstract Acute respiratory distress syndrome (ARDS) is a severe complication of critical illness, characterized by bilateral lung infiltrates and hypoxemia. Its clinical and pathophysiological heterogeneity poses challenges for both diagnosis and treatment. This review outlines the evolution of ARDS definitions, discusses the underlying pathophysiology of ARDS, and examines the clinical implications of its heterogeneity. Traditional

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A narrative review on the future of ARDS: evolving definitions, pathophysiology, and tailored management Read Post »

Respiratory

Rapidly improving ARDS differs clinically and biologically from persistent ARDS

Abstract Background Rapidly improving acute respiratory distress syndrome (RIARDS) is an increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after initiation of mechanical ventilation. Detailed clinical and biological features of RIARDS have not been clearly defined, and it is unknown whether RIARDS is associated with the hypoinflammatory or hyperinflammatory phenotype of ARDS.

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Rapidly improving ARDS differs clinically and biologically from persistent ARDS Read Post »

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