Respiratory

Miscellaneous, Respiratory

Comparative efficacy and safety of pulmonary surfactant delivery strategies in neonatal RDS: a network meta-analysis

Abstract Purpose To compare five pulmonary surfactant (PS) administration strategies for neonates with respiratory distress syndrome (RDS), including intubation-surfactant-extubation (InSurE), thin catheter administration, laryngeal mask airway (LMA), surfactant nebulization (SN), and usual care, with a particular emphasis on the comparison of the LMA and SN with other strategies. Methods We conducted a systematic search of […]

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Respiratory

Understanding ventilator-induced lung injury: The role of mechanical power

Abstract Mechanical ventilation stands as a life-saving intervention in the management of respiratory failure. However, it carries the risk of ventilator-induced lung injury. Despite the adoption of lung-protective ventilation strategies, including lower tidal volumes and pressure limitations, mortality rates remain high, leaving room for innovative approaches. The concept of mechanical power has emerged as a

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Respiratory

The Management of Interstitial Lung Disease in the ICU: A Comprehensive Review

Abstract Interstitial lung disease (ILD) encompasses a diverse group of parenchymal lung diseases characterized by varying degrees of inflammation and/or fibrosis. Patients with ILD frequently require hospitalization, with many needing intensive care unit (ICU) admission, most often due to respiratory failure. The diagnosis and management of ILD in the ICU present unique challenges. Diagnosis primarily

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Respiratory

Inhaled antibiotics for treating pneumonia in invasively ventilated patients in intensive care unit: a meta-analysis of randomized clinical trials with trial sequential analysis

Abstract Background The use of inhaled antibiotics for treating pneumonia in invasively ventilated patients offers a direct approach, allowing for high local concentrations of the drug in the lower respiratory tract while simultaneously reducing systemic toxicity. However, the real efficacy and safety of nebulized antibiotics remain unclear. The aim of the present is to assess

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Inhaled antibiotics for treating pneumonia in invasively ventilated patients in intensive care unit: a meta-analysis of randomized clinical trials with trial sequential analysis Read Post »

Miscellaneous, Respiratory

Development of a predictive nomogram for early identification of pulmonary embolism in hospitalized patients: a retrospective cohort study

Abstract Background Hospitalized patients often present with complex clinical conditions, but there is a lack of effective tools to assess their risk of pulmonary embolism (PE). Therefore, our study aimed to develop a nomogram model for better predicting PE in hospitalized populations. Methods Data from hospitalized patients (aged ≥ 15 years) who underwent computed tomography pulmonary angiography

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Development of a predictive nomogram for early identification of pulmonary embolism in hospitalized patients: a retrospective cohort study Read Post »

Respiratory

Unlocking the power of biomarkers: transforming the diagnosis of acute respiratory distress syndrome

Abstract Acute respiratory distress syndrome (ARDS) remains a significant challenge due to its heterogeneity and lack of targeted therapies. Recent advances in biomarkers offer promise in refining diagnosis, assessing severity, and personalizing treatment strategies. This article explores the evolving role of biomarkers in ARDS, highlighting their potential to enhance clinical precision, differentiate subphenotypes, and guide

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Respiratory

Effect of emodin on acute lung injury: a meta-analysis of preclinical trials

Abstract Background Emodin has protective effects on acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). This meta-analysis intended to illustrate the efficacy of emodin on ALI/ARDS animal models. Methods Relevant preclinical studies were searched on PubMed, EMBASE, and Web of Science. Standardized mean differences (SMDs) with corresponding confidence intervals (CIs) were used to

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Respiratory

Apnea Testing on Conventional Mechanical Ventilation During Brain Death Evaluation

Abstract Introduction The use of continuous positive airway pressure has been shown to improve the tolerance of the apnea test, a critical component of brain death evaluation. The ability to deactivate the apnea backup setting has made apnea testing possible using several conventional mechanical ventilators. Our goal was to evaluate the safety and efficacy of

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Respiratory

Long-acting Muscarinic Antagonists and Their Role in Children with Recurrent Wheezing or Asthma: An Updated Review

Abstract Long-acting muscarinic antagonists (LAMAs) are a class of bronchodilators that work by blocking the muscarinic receptors in the airway smooth muscle, leading to bronchodilation and reduced mucus secretion. They are primarily used in the management of chronic obstructive pulmonary disease, but their use in asthma, including in pediatric patients, has been increasing, especially in

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Respiratory

Challenges in Transitioning from Controlled to Assisted Ventilation in Acute Respiratory Distress Syndrome (ARDS) Management

Abstract Acute respiratory distress syndrome (ARDS) presents significant challenges in critical care, primarily due to its inflammatory nature, which leads to impaired gas exchange and respiratory mechanics. While mechanical ventilation (MV) is essential for patient support, the transition from controlled to assisted ventilation is complex and may be associated with intensive care unit-acquired weakness, ventilator-induced

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