Mechanical Ventilation, Respiratory

Assessment of recruitment from CT to the bedside: challenges and future directions

Abstract Assessing and quantifying recruitability are important for characterizing ARDS severity and for reducing or preventing the atelectrauma caused by the cyclic opening and closing of pulmonary units. Over the years, several methods for recruitment assessment have been developed, grouped into three main approaches: 1) Quantitative CT Scanning: This method accurately measures the amount of […]

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Assessment of recruitment from CT to the bedside: challenges and future directions Read Post »

Circulatory

Immediate Clinical Complications Occurring During Membrane Change in Patients on Veno-Venous Extracorporeal Membrane Oxygenation

Abstract The clinical tolerance of extracorporeal membrane oxygenation (ECMO) membrane changes in acute respiratory distress syndrome (ARDS) patients under veno-venous ECMO (VV-ECMO) has not been reported. The aim of this study was to describe the tolerance of membrane change. Patients requiring VV-ECMO were retrospectively included between March 2020 and May 2022. In case of membrane

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Immediate Clinical Complications Occurring During Membrane Change in Patients on Veno-Venous Extracorporeal Membrane Oxygenation Read Post »

Circulatory

Evolution of Critical Care Cardiology: An Update on Structure, Care Delivery, Training, and Research Paradigms: A Scientific Statement From the American Heart Association

Abstract Critical care cardiology refers to the practice focus of and subspecialty training for the comprehensive management of life-threatening cardiovascular diseases and comorbid conditions that require advanced critical care in an intensive care unit. The development of coronary care units is often credited for a dramatic decline in mortality rates after acute myocardial infarction throughout

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Evolution of Critical Care Cardiology: An Update on Structure, Care Delivery, Training, and Research Paradigms: A Scientific Statement From the American Heart Association Read Post »

Circulatory

Hemodynamic Impact of the Trendelenburg Position: A Systematic Review and Meta-analysis

Abstract Objective To systematically evaluate the impact of the Trendelenburg position on hemodynamic parameters in adult patients. Design Systematic literature review and meta-analysis using PubMed and Medline. Setting All prospective interventional studies comparing the hemodynamic characteristics of patients in the horizontal supine position and Trendelenburg position. Measurements and main results A total of 16 studies

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Hemodynamic Impact of the Trendelenburg Position: A Systematic Review and Meta-analysis Read Post »

Sepsis

Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce

Abstract Sepsis is a leading cause of global mortality in children, yet definitions for pediatric sepsis are outdated and lack global applicability and validity. In adults, the Sepsis-3 Definition Taskforce queried databases from high-income countries to develop and validate the criteria. The merit of this definition has been widely acknowledged; however, important considerations about less-resourced

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Operationalizing Appropriate Sepsis Definitions in Children Worldwide: Considerations for the Pediatric Sepsis Definition Taskforce Read Post »

Pharmacological Insights in Critical Care

Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study

Abstract Purpose Appropriate antifungal therapy is a major determinant of survival in critically ill patients with invasive fungal disease. We sought to describe whether contemporary dosing of antifungals achieves therapeutic exposures in critically ill patients. Methods In a prospective, open-label, multicenter pharmacokinetic study, intensive care unit (ICU) patients prescribed azoles, echinocandins, or polyene antifungals for

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Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study Read Post »

Sepsis

Current perspectives in the management of sepsis and septic shock

Abstract Within patients with sepsis, there exists significant heterogeneity, and while all patients should receive conventional therapy, there are subgroups of patients who may benefit from specific therapies, often referred to as rescue therapies. Therefore, the identification of these specific patient subgroups is crucial and lays the groundwork for the application of precision medicine based

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Current perspectives in the management of sepsis and septic shock Read Post »

Neurology

Treatment-Related Reversible Cerebral Vasoconstriction Syndrome

Abstract Reversible cerebral vasoconstriction syndrome (RCVS) is a rare but significant cause of intracranial arteriopathy and stroke in young adults. The syndrome encompasses a spectrum of disorders radiologically characterized by reversible narrowing and dilation of intracranial arteries, often triggered by vasoactive drugs or the postpartum period. The hallmark clinical feature of RCVS is thunderclap headache

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Treatment-Related Reversible Cerebral Vasoconstriction Syndrome Read Post »

Mechanical Ventilation

Ventilation distribution during spontaneous breathing trials predicts liberation from mechanical ventilation: the VISION study

Abstract Background Predicting complete liberation from mechanical ventilation (MV) is still challenging. Electrical impedance tomography (EIT) offers a non-invasive measure of regional ventilation distribution and could bring additional information. Research question. Whether the display of regional ventilation distribution during a Spontaneous Breathing Trial (SBT) could help at predicting early and successful liberation from MV. Study

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Ventilation distribution during spontaneous breathing trials predicts liberation from mechanical ventilation: the VISION study Read Post »

Mechanical Ventilation

Prolonged weaning from mechanical ventilation: who, what, when and how?

Abstract Weaning from invasive mechanical ventilation is an important part of the management of respiratory failure patients. Patients can be classified into those who wean on the first attempt (simple weaning), those who require up to three attempts (difficult weaning) and those who require more than three attempts (prolonged weaning). The process of weaning includes

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Prolonged weaning from mechanical ventilation: who, what, when and how? Read Post »

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