Critically ill

Respiratory

Airway management in critically ill patients

Summary This comprehensive review highlights the challenges associated with airway management in critically ill patients, emphasizing the high risk of adverse events including cardiovascular collapse and severe hypoxemia. The article delineates evidence-based strategies to optimize hemodynamics and oxygenation during airway management, stressing the importance of meticulous patient evaluation, careful selection of anesthetic agents, the utility […]

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Pharmacological Insights in Critical Care

Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study

Abstract Purpose Appropriate antifungal therapy is a major determinant of survival in critically ill patients with invasive fungal disease. We sought to describe whether contemporary dosing of antifungals achieves therapeutic exposures in critically ill patients. Methods In a prospective, open-label, multicenter pharmacokinetic study, intensive care unit (ICU) patients prescribed azoles, echinocandins, or polyene antifungals for

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Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study Read Post »

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