cytokine storm

Pulmonary

Deep insight into cytokine storm: from pathogenesis to treatment

Summary of Deep Insight into Cytokine Storm: From Pathogenesis to Treatment (Nie et al.) Abstract Summary: Nie et al. provide a comprehensive review on cytokine storm (CS), a severe systemic inflammatory syndrome characterized by excessive immune cell activation and elevated cytokine levels. This paper highlights key signaling pathways involved, associated immune cells, targeted organ damage, […]

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Respiratory

Pathophysiological mechanisms of ARDS: a narrative review from molecular to organ-level perspectives

Abstract Background Acute respiratory distress syndrome (ARDS) remains a life-threatening pulmonary condition with persistently high mortality rates despite significant advancements in supportive care. Its complex pathophysiology involves an intricate interplay of molecular and cellular processes, including cytokine storms, oxidative stress, programmed cell death, and disruption of the alveolar-capillary barrier. These mechanisms drive localized lung injury

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Sepsis

Current perspectives in the management of sepsis and septic shock

Abstract Within patients with sepsis, there exists significant heterogeneity, and while all patients should receive conventional therapy, there are subgroups of patients who may benefit from specific therapies, often referred to as rescue therapies. Therefore, the identification of these specific patient subgroups is crucial and lays the groundwork for the application of precision medicine based

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