March 2025 - Page 2 of 5 - Perfusfind Intensive Care

Pharmacological Insights in Critical Care

Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses

Summary of Haloperidol in Treating Delirium, Reducing Mortality, and Preventing Delirium Occurrence: Bayesian and Frequentist Meta-Analyses Abstract This study evaluates the efficacy and safety of haloperidol for delirium treatment and prevention in ICU patients using Bayesian and frequentist meta-analyses. Seven RCTs (n = 1,767) assessed delirium treatment, while five RCTs (n = 2,509) examined delirium […]

Bayesian meta analysis, Delirium, Haloperidol

Haloperidol in treating delirium, reducing mortality, and preventing delirium occurrence: Bayesian and frequentist meta-analyses Read Post »

Circulatory

The predictive value of highly malignant EEG patterns after cardiac arrest: evaluation of the ERC-ESICM recommendations

Summary of The Predictive Value of Highly Malignant EEG Patterns After Cardiac Arrest: Evaluation of the ERC-ESICM Recommendations Abstract Highly malignant EEG patterns (HMEP), specifically suppression and burst-suppression, are recommended by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) for predicting poor neurological outcomes after cardiac arrest. This study,

Brain injury, cardiac arrest, coma, EEG

The predictive value of highly malignant EEG patterns after cardiac arrest: evaluation of the ERC-ESICM recommendations Read Post »

Respiratory

Recent Advances and Future Directions in Extracorporeal Carbon Dioxide Removal

Abstract Extracorporeal carbon dioxide removal (ECCO2R) is an emerging technique designed to reduce carbon dioxide (CO2) levels in venous blood while enabling lung-protective ventilation or alleviating the work of breathing. Unlike high-flow extracorporeal membrane oxygenation (ECMO), ECCO2R operates at lower blood flows (0.4–1.5 L/min), making it less invasive, with smaller cannulas and simpler devices. Despite

ARDS, carbon dioxide, carbon dioxide removal, CO2, ECCO₂R, ECCOR, ecmo

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Mechanical Ventilation

Setting the ventilator with AI support: challenges and perspectives

Mechanical ventilation (MV) is a cornerstone of intensive care medicine. However, when used inappropriately, it can cause additional harm, including a condition known as ventilator-induced lung injury (VILI) [1]. To mitigate this risk, lung-protective ventilation strategies are of utmost importance. It is, however, essential to note that lung-protective ventilation is also currently evolving from “standard

AI, mechanical ventilation

Setting the ventilator with AI support: challenges and perspectives Read Post »

Mechanical Ventilation

Mechanical ventilation energy analysis: Recruitment focuses injurious power in the ventilated lung

Abstract The progression of acute respiratory distress syndrome (ARDS) from its onset due to disease or trauma to either recovery or death is poorly understood. Currently, there are no generally accepted treatments aside from supportive care using mechanical ventilation. However, this can lead to ventilator-induced lung injury (VILI), which contributes to a 30 to 40%

energy transfer, lung injury, mechanical ventilation, ventilation strategies

Mechanical ventilation energy analysis: Recruitment focuses injurious power in the ventilated lung Read Post »

Circulatory, Respiratory

Managing Refractory Hypoxemia in ARDS Obese Patients with Veno-Venous Extra-Corporeal Membrane Oxygenation: A Narrative Review

Abstract Veno-venous extracorporeal membrane oxygenation (vvECMO) is a life-saving intervention for severe respiratory failure unresponsive to conventional therapies. However, managing refractory hypoxemia in morbidly obese patients poses significant challenges due to the unique physiological characteristics of this population, including hyperdynamic circulation, elevated cardiac output, and increased oxygen consumption. These factors can limit the effectiveness of

ARDS, ecmo, hypoxemia, obese, PEEP, VV-ecmo

Managing Refractory Hypoxemia in ARDS Obese Patients with Veno-Venous Extra-Corporeal Membrane Oxygenation: A Narrative Review Read Post »

Mechanical Ventilation

Navigating Heart–Lung Interactions in Mechanical Ventilation: Pathophysiology, Diagnosis, and Advanced Management Strategies in ARDS and Beyond

Abstract Patients in critical condition who require mechanical ventilation experience intricate interactions between their respiratory and cardiovascular systems. These complex interactions are crucial for clinicians to understand as they can significantly influence therapeutic decisions and patient outcomes. A deep understanding of heart–lung interactions is essential, particularly under the stress of mechanical ventilation, where the right

ARDS, heart–lung interactions, mechanical circulatory support, mechanical ventilation, PEEP, Positive End-Expiratory Pressure (PEEP), right ventricle

Navigating Heart–Lung Interactions in Mechanical Ventilation: Pathophysiology, Diagnosis, and Advanced Management Strategies in ARDS and Beyond Read Post »

Mechanical Ventilation, Miscellaneous

Debate on the Role of Eccentric Contraction of the Diaphragm: Is It Always Harmful?

Abstract The diaphragm is the primary muscle involved in the ventilatory pump, making it a vital component in mechanical ventilation. Various factors in patients who require mechanical ventilation can lead to the deterioration of the diaphragm, which is associated with increased mortality. This deterioration can arise from either excessive or insufficient support due to improper

Diaphragm, mechanical ventilation, reverse triggering, ventilator weaning

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Pharmacological Insights in Critical Care

Inhaled Sedation in Acute Respiratory Distress Syndrome. The SESAR Randomized Clinical Trial

Summary of “Inhaled Sedation in Acute Respiratory Distress Syndrome: The SESAR Randomized Clinical Trial” Abstract This randomized clinical trial compared the efficacy and safety of inhaled sevoflurane versus intravenous propofol for sedation in patients with moderate to severe acute respiratory distress syndrome (ARDS). Conducted across 37 French ICUs, the study enrolled 687 patients to determine

ARDS, Inhaled Sedation, SESAR Trial

Inhaled Sedation in Acute Respiratory Distress Syndrome. The SESAR Randomized Clinical Trial Read Post »

Respiratory

Electrical impedance tomography-guided the optimal awake prone position in a moderate ARDS patient

Awake prone positioning (APP) has gained prominence as a therapeutic intervention for acute respiratory distress syndrome (ARDS), particularly in COVID-19-related respiratory failure due to its proven survival benefits [1, 2]. However, the clinical applicability of APP in non-COVID-19 ARDS populations remains controversial, with patient tolerance and heterogeneous lung recruitment responses posing significant challenges [3]. To address

ARDS, Awake prone positioning (APP), Electric Impedance Tomography, prone position, tomography

Electrical impedance tomography-guided the optimal awake prone position in a moderate ARDS patient Read Post »