Abstract Background Neonatal encephalopathy (NE) due to suspected hypoxic-ischemic encephalopathy (HIE), referred to as NESHIE, is a clinical diagnosis in late preterm and term newborns. It occurs as a result of impaired cerebral blood flow and oxygen delivery during the peripartum period and is used until other causes of NE have been discounted and HIE […]
Abstract This review explores the complex interactions between sedation and invasive ventilation and examines the potential of volatile anesthetics for lung- and diaphragm-protective sedation. In the early stages of invasive ventilation, many critically ill patients experience insufficient respiratory drive and effort, leading to compromised diaphragm function. Compared with common intravenous agents, inhaled sedation with volatile anesthetics
Volatile anesthetics for lung- and diaphragm-protective sedation Read Post »
Summary of “Knowing the Ropes of Vasopressor Dosing: A Focus on Norepinephrine” Abstract Summary: This editorial discusses the pharmacological properties, dosing strategies, and clinical considerations for norepinephrine, the first-line vasopressor in managing shock. It highlights the complexities of dosing in critically ill patients, variability in pharmacodynamics, and the need for individualized therapy. The authors emphasize
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Summary of “Practical Assessment of Risk of VILI from Ventilating Power: A Conceptual Model” Abstract Summary: This article introduces a conceptual model for assessing the risk of ventilator-induced lung injury (VILI) based on mechanical power and its components, such as tidal volume, driving pressure (DP), plateau pressure (Ps), and ventilating frequency. By focusing on the
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Summary of “The Respiratory Mechanics of COVID-19 Acute Respiratory Distress Syndrome—Lessons Learned?” Abstract Summary: The COVID-19 pandemic has expanded our understanding of acute respiratory distress syndrome (ARDS), revealing unique pathophysiological characteristics of COVID-19 ARDS. Distinct features include severe hypoxemia, vascular injury, and microthrombosis, often disproportionate to respiratory compliance. These findings challenge conventional ARDS management strategies,
Summary of “Assessing lung recruitability: does it help with PEEP settings?” This editorial examines the relationship between lung recruitability and the selection of positive end-expiratory pressure (PEEP) settings in acute respiratory distress syndrome (ARDS) management. While recruitability measures the potential to reinflate atelectatic lung regions, PEEP must prevent their collapse while considering additional factors like
Ventilator induced lung injury: a case for a larger umbrella? Read Post »
Abstract With the large volume of data coming from implemented technologies and monitoring systems, intensive care units (ICUs) represent a key area for artificial intelligence (AI) application. Despite the last decade has been marked by studies focused on the use of AI in medicine, its application in mechanical ventilation management is still limited. Optimizing
Abstract Background Ventilator weaning is of great importance for intensive care patients in order to avoid complications caused by prolonged ventilation. However, not all patients succeed in weaning immediately. Their spontaneous breathing may be insufficient, resulting in extubation failure and the subsequent need for reintubation. To identify patients at high risk for weaning failure, a
Abstract Injury to the spleen is one of the most common solid organ injuries in blunt trauma1. Following the primary and secondary survey in an injured patient, the potential dynamic alteration in the event of ongoing haemorrhage should be kept in mind. A sick patient should be in the operating theatre unless response to resuscitation
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Abstract A connection between diabetes and an increased risk of epilepsy has been suggested by observational studies. Animal studies have also shown that antihyperglycemic drugs can improve seizures. However, it is unclear whether antihyperglycemic drugs have a causal role in epilepsy in humans. To investigate this potential causal relationship, a Mendelian randomisation study was