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Circulatory

The effects of blood cell salvage on transfusion requirements after decannulation from veno-venous extracorporeal membrane oxygenation: an emulated trial analysis

Abstract Background Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a supportive therapy for acute respiratory failure with increased risk of packed red blood cells (PRBC) transfusion. Blood cell salvage (BCS) aims to reduce blood transfusion, but its efficacy is unclear. This study aimed to estimate the effect of BCS at the time of removal of the […]

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The effects of blood cell salvage on transfusion requirements after decannulation from veno-venous extracorporeal membrane oxygenation: an emulated trial analysis Read Post »

Sepsis

Differential effects of thiamine and ascorbic acid in clusters of septic patients identified by latent variable analysis

Abstract Background Thiamine and ascorbic acid have been proposed to mitigate the devastating consequences of sepsis and septic shock. To date, randomized controlled trials have failed to demonstrate a benefit of these therapies and heterogeneity of treatment effect is suspected. In this study, we aimed at assessing the heterogeneity of treatment effect of thiamine (B1)

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Differential effects of thiamine and ascorbic acid in clusters of septic patients identified by latent variable analysis Read Post »

Artificial Intelligence

NeoVault: empowering neonatal research through a neonate data hub

Abstract Background Stability during early postnatal life in preterm infants is related to better outcomes. Although vital signs are monitored continuously in Neonatal Intensive Care Unites, this monitoring does not include all physiological parameters nor data such as movement patterns. Although there are scattered sources of data, there is no centralized data hub for neonates

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NeoVault: empowering neonatal research through a neonate data hub Read Post »

Uncategorized

D-PRISM: a global survey-based study to assess diagnostic and treatment approaches in pneumonia managed in intensive care

Abstract Background Pneumonia remains a significant global health concern, particularly among those requiring admission to the intensive care unit (ICU). Despite the availability of international guidelines, there remains heterogeneity in clinical management. The D-PRISM study aimed to develop a global overview of how pneumonias (i.e., community-acquired (CAP), hospital-acquired (HAP), and Ventilator-associated pneumonia (VAP)) are diagnosed

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D-PRISM: a global survey-based study to assess diagnostic and treatment approaches in pneumonia managed in intensive care Read Post »

Neurology

Care of the Patient Nearing the End of Life in the Neurointensive Care Unit

Abstract Background Neurologically critically ill patients present with unique disease trajectories, prognostic uncertainties, and challenges to end-of-life (EOL) care. Acute brain injuries place these patients at risk for underrecognized symptoms and unmet EOL management needs, which can negatively affect their quality of care and lead to complicated grief in surviving loved ones. To care for

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Care of the Patient Nearing the End of Life in the Neurointensive Care Unit Read Post »

Sepsis

Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials

Abstract Background Treatment with short-acting betablockers in septic patients remains controversial. Two recent large multicenter trials have provided additional evidence on this therapeutic approach. We thus performed a meta-analysis, including the most recent data, to evaluate the potential impacts of treatment with short-acting betablockers on mortality in adult septic patients. Methods The data search included

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Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials Read Post »

Uncategorized

Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial

Abstract Background Postextubation respiratory failure (PRF) frequently complicates weaning from mechanical ventilation and may increase morbidity/mortality. Noninvasive ventilation (NIV) alternating with high-flow nasal oxygen (HFNO) may prevent PRF. Methods Ventilated patients without chronic obstructive pulmonary disease (COPD) and at high-risk of PRF defined as a lung ultrasound score (LUS) ≥ 14 assessed during the spontaneous breathing trial,

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Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial Read Post »

Mechanical Ventilation, Miscellaneous

How we use ultrasound in the management of weaning from mechanical ventilation

Difficult weaning from invasive mechanical ventilation is associated with adverse clinical outcome and increased use of limited health care resources. Difficult weaning, characterized by failure of multiple spontaneous breathing trails (SBTs), can result from several causes, including impaired function of lung, heart, and respiratory pump [1]. In this editorial, we discuss how ultrasound may facilitate

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How we use ultrasound in the management of weaning from mechanical ventilation Read Post »

Circulatory

Anticoagulation management during veno-venous ECMO support because of ARDS: Single-center experience

Abstract   Background Patients with severe acute respiratory distress syndrome (ARDS) show a high mortality rate of up to 60 %. In such cases, extracorporeal membrane oxygenation (ECMO) support is often required, which would necessitate anticoagulation therapy, predominantly with heparin. Some bleeding events occurred more frequently in patients during the COVID-19 pandemic who were on venovenous

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Anticoagulation management during veno-venous ECMO support because of ARDS: Single-center experience Read Post »

Circulatory

ECMO-weaning facilitated by neurally adjusted ventilatory assist (NAVA): a case for principal clarification

Abstract The use of veno-venous extracorporeal membrane oxygenation (VV-ECMO) has become increasingly prevalent, particularly in respiratory disease pandemics such as H1N1-influenza and SARS-CoV-2. This surge has emphasized the importance of clear therapy recommendations, improved accessibility to ECMO technology, established ECMO teams, and structured networks to ensure access to specialized care throughout the course of the

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ECMO-weaning facilitated by neurally adjusted ventilatory assist (NAVA): a case for principal clarification Read Post »

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