Author name: admin

Pharmacological Insights in Critical Care

Activity of Antiseptics Against Pseudomonas aeruginosa and Its Adaptation Potential

Abstract Background/Objectives: Pseudomonas aeruginosa rapidly acquires antibiotic resistance and demonstrates increasing tolerance to antiseptics. This study evaluated the activity of eight antiseptics against P. aeruginosa, assessed its ability to develop adaptation to these antiseptics, and, for the first time, determined the Karpinski Adaptation Index (KAI) for this bacterium. Methods: The minimal inhibitory concentration (MIC), susceptibility to antibiotics, bactericidal […]

, ,

Activity of Antiseptics Against Pseudomonas aeruginosa and Its Adaptation Potential Read Post »

Mechanical Ventilation, Respiratory

Neonatal intubation: what are we doing?

Abstract How and when the forces are applied during neonatal intubation are currently unknown. This study investigated the pattern of the applied forces by using sensorized laryngoscopes during the intubation process in a neonatal manikin. Nine users of direct laryngoscope and nine users of straight-blade video laryngoscope were included in a neonatal manikin study. During

,

Neonatal intubation: what are we doing? Read Post »

Sepsis

Megakaryocyte in sepsis: the trinity of coagulation, inflammation and immunity

Abstract Background Megakaryocytes are traditionally recognized as cells responsible for platelet production. However, beyond their role in thrombopoiesis, megakaryocytes also participate in inflammatory responses and regulate immune system functions. Sepsis, characterized by life-threatening organ dysfunction due to a dysregulated response to infection, prominently features coagulopathy, severe inflammation, and immune dysfunction as key pathophysiological aspects. Aim

, , , ,

Megakaryocyte in sepsis: the trinity of coagulation, inflammation and immunity Read Post »

Neurology

Feasibility Study of Endoscopic Surgery for Spontaneous Intracerebral Hemorrhage with Large Hematoma: a Comparison with Craniotomy Using Propensity Score Matching Analysis

Abstract Background Spontaneous intracerebral hemorrhage (ICH) with large hematomas is commonly treated with craniotomy combined with decompressive craniectomy, procedures that involve huge trauma and require subsequent cranioplasty. Recently, endoscopic surgery has shown significant promise in treating ICH, but its feasibility for large hematomas remains uncertain. Therefore, this study aims to compare endoscopic surgery with craniotomy

, , , ,

Feasibility Study of Endoscopic Surgery for Spontaneous Intracerebral Hemorrhage with Large Hematoma: a Comparison with Craniotomy Using Propensity Score Matching Analysis Read Post »

Mechanical Ventilation, Respiratory

Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges

Abstract Ventilator-associated pneumonia (VAP) affects up to 20% of critically ill patients and induces significant antibiotic prescription pressure, accounting for half of all antibiotic use in the ICU. VAP significantly increases hospital length of stay and healthcare costs yet is also associated with long-term morbidity and mortality. The diagnosis of VAP continues to present challenges

, , ,

Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges Read Post »

Miscellaneous

The non-haemorrhagic vagal response to trauma: a review of hypotensive and bradycardic responses to injury in the absence of bleeding

Abstract Purpose Trauma has the potential to cause haemorrhage, tissue damage, pain, visceral manipulation and psychological distress. Each of these consequences of trauma can cause changes in autonomic outflow, which dictates a patient’s vital signs. Patients who are hypotensive and bradycardic due to a vagally mediated parasympathetic response to pain, psychological distress and visceral manipulation

, , ,

The non-haemorrhagic vagal response to trauma: a review of hypotensive and bradycardic responses to injury in the absence of bleeding Read Post »

Pharmacological Insights in Critical Care, Sepsis

Ivabradine in Septic Shock: A Narrative Review

Abstract In patients with septic shock, compensatory tachycardia initially serves to maintain adequate cardiac output and tissue oxygenation but may persist despite appropriate fluid and vasopressor resuscitation. This sustained elevation in heart rate and altered heart rate variability, indicative of autonomic dysfunction, is a well-established independent predictor of adverse outcomes in critical illness. Elevated heart

, , , , ,

Ivabradine in Septic Shock: A Narrative Review Read Post »

Miscellaneous, Respiratory

Comparative efficacy and safety of pulmonary surfactant delivery strategies in neonatal RDS: a network meta-analysis

Abstract Purpose To compare five pulmonary surfactant (PS) administration strategies for neonates with respiratory distress syndrome (RDS), including intubation-surfactant-extubation (InSurE), thin catheter administration, laryngeal mask airway (LMA), surfactant nebulization (SN), and usual care, with a particular emphasis on the comparison of the LMA and SN with other strategies. Methods We conducted a systematic search of

Comparative efficacy and safety of pulmonary surfactant delivery strategies in neonatal RDS: a network meta-analysis Read Post »

Sepsis

The role of peripheral perfusion markers and lactate in septic shock resuscitation

Abstract Septic shock leads to progressive hypoperfusion and tissue hypoxia. Unfortunately, numerous uncertainties exist around the best monitoring strategy, as available techniques are mere surrogates for these phenomena. Nevertheless, central venous oxygen saturation (ScvO2), venous-to-arterial CO2 gap, and lactate normalization have been fostered as resuscitation targets for septic shock. Moreover, recent evidence has challenged the central role of lactate. Following

, ,

The role of peripheral perfusion markers and lactate in septic shock resuscitation Read Post »

Mechanical Ventilation

Using the ventilator to predict fluid responsiveness

During acute circulatory failure, infusing fluids as first line therapy is the source of a therapeutic dilemma [increase in cardiac output (CO) and improvement of tissue perfusion vs. inconsistent effectiveness and risk of fluid accumulation]. Predicting effectiveness of a fluid bolus on CO before infusing it avoids administering fluid to patients who do not require

, ,

Using the ventilator to predict fluid responsiveness Read Post »

Scroll to Top