platelet

Cardiovascular

Thrombocytopenia in the intensive care unit: diagnosis and management

Summary Thrombocytopenia is a common complication among critically ill patients, defined by platelet counts below 150 × 10⁹/L or a relative decrease by more than 30–50%. It significantly impacts patient outcomes due to increased bleeding risks and worse prognoses. The mechanisms underlying thrombocytopenia in the ICU are diverse, involving peripheral consumption, destruction, sequestration, dilution, or […]

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Sepsis

Megakaryocyte in sepsis: the trinity of coagulation, inflammation and immunity

Abstract Background Megakaryocytes are traditionally recognized as cells responsible for platelet production. However, beyond their role in thrombopoiesis, megakaryocytes also participate in inflammatory responses and regulate immune system functions. Sepsis, characterized by life-threatening organ dysfunction due to a dysregulated response to infection, prominently features coagulopathy, severe inflammation, and immune dysfunction as key pathophysiological aspects. Aim

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