infection archivos - Perfusfind Intensive Care

Pharmacological Insights in Critical Care

Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study

Abstract Purpose Appropriate antifungal therapy is a major determinant of survival in critically ill patients with invasive fungal disease. We sought to describe whether contemporary dosing of antifungals achieves therapeutic exposures in critically ill patients. Methods In a prospective, open-label, multicenter pharmacokinetic study, intensive care unit (ICU) patients prescribed azoles, echinocandins, or polyene antifungals for […]

antifungal, Antifungals, Critically ill, infection, Intensive care unit, Invasive fungal disease, Pharmacokinetics, Pharmacology

Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study Read Post »

Mechanical Ventilation, Respiratory

Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges

Abstract Ventilator-associated pneumonia (VAP) affects up to 20% of critically ill patients and induces significant antibiotic prescription pressure, accounting for half of all antibiotic use in the ICU. VAP significantly increases hospital length of stay and healthcare costs yet is also associated with long-term morbidity and mortality. The diagnosis of VAP continues to present challenges

Clinical microbiology, Diagnostic markers, infection, Respiratory signs and symptoms

Ventilator-associated pneumonia: pathobiological heterogeneity and diagnostic challenges Read Post »

Respiratory

Inhaled antibiotics for treating pneumonia in invasively ventilated patients in intensive care unit: a meta-analysis of randomized clinical trials with trial sequential analysis

Abstract Background The use of inhaled antibiotics for treating pneumonia in invasively ventilated patients offers a direct approach, allowing for high local concentrations of the drug in the lower respiratory tract while simultaneously reducing systemic toxicity. However, the real efficacy and safety of nebulized antibiotics remain unclear. The aim of the present is to assess

Antibiotics, infection, Inhaled, invasive ventilation, Multi-drug resistant, Multi-drug resistant organism, pneumonia

Inhaled antibiotics for treating pneumonia in invasively ventilated patients in intensive care unit: a meta-analysis of randomized clinical trials with trial sequential analysis Read Post »