March 2026

Sepsis

The Sepsis Chain of Survival: A Comprehensive Framework for Improving Sepsis Outcomes

Summary The article introduces the “Sepsis Chain of Survival,” a structured, interconnected framework designed to improve sepsis management and patient outcomes globally. Originally inspired by the cardiac arrest chain of survival concept, this comprehensive model underscores crucial components such as community and healthcare awareness, early recognition and intervention, prompt antimicrobial and fluid therapy, optimized critical […]

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Cardiovascular

Thrombocytopenia in the intensive care unit: diagnosis and management

Summary Thrombocytopenia is a common complication among critically ill patients, defined by platelet counts below 150 × 10⁹/L or a relative decrease by more than 30–50%. It significantly impacts patient outcomes due to increased bleeding risks and worse prognoses. The mechanisms underlying thrombocytopenia in the ICU are diverse, involving peripheral consumption, destruction, sequestration, dilution, or

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