June 2025

Sepsis

Sepsis and post-sepsis syndrome: a multisystem challenge requiring comprehensive care and management—a review

Summary: This comprehensive review discusses the multifaceted nature of sepsis, emphasizing its high mortality and complex management, spanning early recognition, acute intervention, and long-term rehabilitation. Post-sepsis syndrome (PSS) represents a critical challenge with sustained immune dysregulation, chronic inflammation, and metabolic dysfunction leading to recurrent infections, cardiovascular disease, and neurocognitive impairment. The review underscores mitochondrial dysfunction, […]

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Mechanical Ventilation

Bridging the gap: Enhancing synchrony in mechanical ventilation

Summary This review extensively analyzes the physiological control mechanisms of ventilation and their interaction with mechanical ventilators, highlighting advanced technologies aimed at improving patient-ventilator synchrony. Ventilator dyssynchrony—defined as a mismatch between patient respiratory effort and ventilator support—remains prevalent, contributing significantly to adverse outcomes, including prolonged ventilation, diaphragm dysfunction, extended ICU stays, and increased mortality. The

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Pulmonary

First real-time imaging of bronchoscopic lung volume reduction by electrical impedance tomography

Summary: “First real-time imaging of bronchoscopic lung volume reduction by electrical impedance tomography” Abstract Summary: This study investigated the real-time effects of inspired oxygen fraction (FIO₂) on regional lung volumes and ventilation/perfusion during bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBVs), utilizing electrical impedance tomography (EIT). The findings demonstrate that higher FIO₂ significantly accelerates

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First real-time imaging of bronchoscopic lung volume reduction by electrical impedance tomography Read Post »

Uncategorized

A Critical Reappraisal of Haloperidol for Delirium Management in the Intensive Care Unit: Perspective from Psychiatry

Summary: “A Critical Reappraisal of Haloperidol for Delirium Management in the Intensive Care Unit: Perspective from Psychiatry” Abstract Summary: This review critically examines the use of haloperidol for managing delirium in ICU settings from a psychiatric perspective. Despite historical and ongoing use of haloperidol, recent randomized controlled trials (RCTs) have questioned its effectiveness, primarily due

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A Critical Reappraisal of Haloperidol for Delirium Management in the Intensive Care Unit: Perspective from Psychiatry Read Post »

Uncategorized

Timing of mechanical ventilation and its association with in-hospital outcomes in patients with cardiogenic shock following ST-elevation myocardial infarction: a multicentre observational study

Summary: Timing of mechanical ventilation and its association with in-hospital outcomes in patients with cardiogenic shock following ST-elevation myocardial infarction: a multicentre observational study Abstract Summary: This multicentre observational study by Arabi and colleagues investigates the impact of mechanical ventilation (MV) timing on outcomes in 672 patients with STEMI complicated by cardiogenic shock (CS). The

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Timing of mechanical ventilation and its association with in-hospital outcomes in patients with cardiogenic shock following ST-elevation myocardial infarction: a multicentre observational study Read Post »

Miscellaneous

Macrophage pyroptosis and its crucial role in ALI/ARDS

Summary: “Macrophage Pyroptosis and its Crucial Role in ALI/ARDS” Abstract Summary: This comprehensive review explores macrophage pyroptosis, a specific form of programmed cell death, and its pivotal role in the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Highlighting complex molecular pathways and inflammasome activation mechanisms, the authors detail the relationship

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Mechanical Ventilation

Development and validation of a machine learning model for real-time prediction of invasive mechanical ventilation weaning readiness

Summary: “Development and validation of a machine learning model for real-time prediction of invasive mechanical ventilation weaning readiness” Abstract Summary: This study aimed to develop and validate a real-time bedside machine learning (ML) decision support tool to predict invasive mechanical ventilation (IMV) weaning readiness using electronic health records. Leveraging extensive data from the MIMIC-IV and

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Development and validation of a machine learning model for real-time prediction of invasive mechanical ventilation weaning readiness Read Post »

Circulatory

Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest

Summary of “Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest” Abstract Summary: Extracorporeal cardiopulmonary resuscitation (ECPR), using venoarterial ECMO during refractory cardiac arrest, can restore circulation and improve outcomes compared with conventional CPR (CCPR) alone. While evidence suggests ECPR enhances survival with favorable neurological recovery, its complexity, resource demands, costs, and complication risks restrict widespread use.

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Pulmonary

Ventilator-Induced Lung Injury: The Unseen Challenge in Acute Respiratory Distress Syndrome Management

Summary of “Ventilator-Induced Lung Injury: The Unseen Challenge in Acute Respiratory Distress Syndrome Management” (Merola et al.) Abstract Summary: Merola et al. comprehensively review ventilator-induced lung injury (VILI) within acute respiratory distress syndrome (ARDS) management, underscoring the complex interplay of pathophysiological mechanisms. The authors discuss traditional and emerging concepts such as volutrauma, barotrauma, atelectrauma, biotrauma,

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