May 2025

Pulmonary

How to approach a patient hospitalized for pneumonia who is not responding to treatment?

Summary of “How to Approach a Patient Hospitalized for Pneumonia Who is Not Responding to Treatment?” (Povoa et al.) Abstract Summary: Povoa et al. provide a structured approach for clinicians managing patients hospitalized for pneumonia who do not respond adequately to initial antibiotic therapy. Non-response, defined as persistent or worsening clinical signs after 48-72 hours, […]

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Respiratory

Peri-intubation complications in critically ill obese patients: a secondary analysis of the international INTUBE cohort

Summary of Peri-intubation complications in critically ill obese patients: a secondary analysis of the international INTUBE cohort (Russotto et al.) Abstract Summary: Russotto et al. conducted a secondary analysis of the INTUBE study, a multicenter international observational cohort, to evaluate peri-intubation adverse events in critically ill obese patients (BMI ≥ 30 kg/m²). They found a

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Peri-intubation complications in critically ill obese patients: a secondary analysis of the international INTUBE cohort Read Post »

Pulmonary

Deep insight into cytokine storm: from pathogenesis to treatment

Summary of Deep Insight into Cytokine Storm: From Pathogenesis to Treatment (Nie et al.) Abstract Summary: Nie et al. provide a comprehensive review on cytokine storm (CS), a severe systemic inflammatory syndrome characterized by excessive immune cell activation and elevated cytokine levels. This paper highlights key signaling pathways involved, associated immune cells, targeted organ damage,

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Respiratory

Driving pressure-guided ventilation decreases the mechanical power compared to predicted body weight-guided ventilation in the ARDS.

Summary of Driving Pressure-Guided Ventilation Decreases the Mechanical Power Compared to Predicted Body Weight-Guided Ventilation in the Acute Respiratory Distress Syndrome (Haudebourg et al.) Abstract Summary: Haudebourg et al. investigated the impact of driving pressure (ΔP)-guided ventilation versus predicted body weight (PBW)-guided ventilation on mechanical power in moderate-to-severe acute respiratory distress syndrome (ARDS) patients. Their

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Driving pressure-guided ventilation decreases the mechanical power compared to predicted body weight-guided ventilation in the ARDS. Read Post »

Pharmacological Insights in Critical Care

Role of liposomal amphotericin B in intensive care unit: an expert opinion paper

Summary of Role of Liposomal Amphotericin B in Intensive Care Unit: An Expert Opinion Paper (Bussini et al.) Abstract Summary: Bussini et al. provide an expert opinion on the appropriate clinical use of Liposomal Amphotericin B (L-AmB) in treating invasive fungal infections (IFI) within the intensive care unit (ICU). The authors detail the limitations of

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