Abstract Background Efficacy of inhaled therapy such as Nitric Oxide (iNO) during mechanical ventilation may depend on airway patency. We hypothesized that airway closure and lung collapse, countered by positive end-expiratory pressure (PEEP), influence iNO efficacy. This could support the role of an adequate PEEP titration for inhalation therapy. The main aim of this study […]
Introduction My goal is to discuss the significant improvement in mortality rates for respiratory distress syndrome (RDS) due to new therapies. In the 1950s and 1960s, mortality rates were approximately 50% (Fig. 1); however, with the introduction of CPAP, surfactant therapy, antenatal steroids, and mechanical ventilation, today’s mortality rate has dropped to less than 2%. This
Respiratory distress syndrome is the poster child for neonatology Read Post »
Abstract Background Phospholipid transfer protein (PLTP), a glycoprotein widely expressed in the body, is primarily involved in plasma lipoprotein metabolism. Previous research has demonstrated that PLTP can exert anti-inflammatory effects and improve individual survival in patients with sepsis and endotoxemia by neutralizing LPS and facilitating LPS clearance. However, the role of PLTP in sepsis-associated acute
The role of phospholipid transfer protein in sepsis-associated acute kidney injury Read Post »
Abstract Background Traumatic brain injury (TBI) is a major public health concern worldwide, contributing to high rates of injury-related death and disability. Severe traumatic brain injury (sTBI), although it accounts for only 10% of all TBI cases, results in a mortality rate of 30–40% and a significant burden of disability in those that survive. This