Abstract Objectives Inadequate heparin response is frequently observed in neonates and young infants. While low antithrombin level is considered to be the primary cause, the existing literature suggests that it is not necessarily responsible. However, granular coagulation factor profiling data are rather limited. Design Prospective, single-center study. Setting Tertiary academic..
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Abstract Objectives To determine the prevalence of iron deficiency and iron deficiency anemia and their association with adverse outcomes in children undergoing cardiac surgery with cardiopulmonary bypass. Design Retrospective review. Setting Single-center, academic quaternary children’s hospital. Participants Eight hundred eighty-six cardiac surgery patients aged 0 to 18 years at the..
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Abstract Objectives: Pediatric in-hospital cardiac arrest (IHCA) events leading to extracorporeal cardiopulmonary resuscitation (E-CPR) most often occur in the ICU in cardiac patients. Since there is little information about using E-CPR for pediatric IHCA in the emergency department (ED), we aimed to describe this population. Design: The American Heart Association’s..
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Abstract Background Infants with congenital diaphragmatic hernia (CDH) are at increased risk of neuroimaging abnormalities and neurodevelopmental impairment. There is no standardized neuroimaging scoring system in this patient population. Our objective was to develop a novel Neonatal Brain Injury Score (NBIS) and evaluate its association with neurodevelopmental outcomes. Methods We..
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Abstract Background Congenital heart disease affects approximately 1% of live births worldwide and remains among the most significant contributors to neonatal morbidity and mortality. Approximately half of them require surgical or percutaneous interventions at some stage. Patient care involves critical situations including clinical, psychological, social, regional, and cultural practices. Family..
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Abstract Background Neonatal cardiac surgery is associated with high morbidity and mortality. Perioperative metabolic stress may result in distinct metabolic phenotypes associated with adverse clinical outcomes. Objectives The purpose of this study was to identify perioperative metabolomic phenotypes associated with adverse clinical outcomes in neonates undergoing cardiac surgery with cardiopulmonary..
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Abstract Objective: To describe surgical outcomes, in-hospital mortality, and variables associated with mortality in pediatric patients with congenital heart disease (CHD) at a national referral center in México over 14 years. Methodology: Retrospective cross-sectional study of 4494 patients under 18 years of age with CHD undergoing cardiac surgery (2010-2024) at..
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Abstract Importance Cyanotic congenital heart diseases, which occur in approximately 0.2% of live births in the United States, have high mortality rates if untreated, but survival to adulthood is common with current surgical interventions. Observations Approximately 80% of all cyanotic congenital heart diseases are caused by tetralogy of Fallot (TOF), D-loop transposition..
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Abstract Neurological injury remains a major concern during neonatal aortic arch surgery. Near-infrared spectroscopy (NIRS) is commonly used to monitor cerebral oxygenation but does not provide direct quantitative information on cerebral blood flow. Transit-time flow measurement (TTFM) allows real-time volumetric flow assessment and may represent an additional tool for intraoperative..
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Abstract Background Optimal oxygenation strategies during cardiopulmonary bypass (CPB) in children with cyanotic congenital heart disease remain controversial. Although hyperoxia has traditionally been used to compensate for chronic hypoxemia, concerns exist regarding reoxygenation injury and oxidative stress. This systematic review and meta-analysis aimed to compare perioperative normoxic versus hyperoxic strategies..
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