Pediatric

Perfusfind S.L.

Abstract Background Congenital heart disease affects approximately 1% of live births worldwide and remains among the most significant contributors to neonatal morbidity and mortality. Approximately half of them require surgical or percutaneous interventions at some stage. Patient care involves critical situations including clinical, psychological, social, regional, and cultural practices. Family..

Perfusfind S.L.

Abstract Background Neonatal cardiac surgery is associated with high morbidity and mortality. Perioperative metabolic stress may result in distinct metabolic phenotypes associated with adverse clinical outcomes. Objectives The purpose of this study was to identify perioperative metabolomic phenotypes associated with adverse clinical outcomes in neonates undergoing cardiac surgery with cardiopulmonary..

Perfusfind S.L.

Abstract Objective: To describe surgical outcomes, in-hospital mortality, and variables associated with mortality in pediatric patients with congenital heart disease (CHD) at a national referral center in México over 14 years. Methodology: Retrospective cross-sectional study of 4494 patients under 18 years of age with CHD undergoing cardiac surgery (2010-2024) at..

Perfusfind S.L.

Abstract Importance  Cyanotic congenital heart diseases, which occur in approximately 0.2% of live births in the United States, have high mortality rates if untreated, but survival to adulthood is common with current surgical interventions. Observations  Approximately 80% of all cyanotic congenital heart diseases are caused by tetralogy of Fallot (TOF), D-loop transposition..

Perfusfind S.L.

Abstract Neurological injury remains a major concern during neonatal aortic arch surgery. Near-infrared spectroscopy (NIRS) is commonly used to monitor cerebral oxygenation but does not provide direct quantitative information on cerebral blood flow. Transit-time flow measurement (TTFM) allows real-time volumetric flow assessment and may represent an additional tool for intraoperative..

Perfusfind S.L.

Abstract Background Optimal oxygenation strategies during cardiopulmonary bypass (CPB) in children with cyanotic congenital heart disease remain controversial. Although hyperoxia has traditionally been used to compensate for chronic hypoxemia, concerns exist regarding reoxygenation injury and oxidative stress. This systematic review and meta-analysis aimed to compare perioperative normoxic versus hyperoxic strategies..

Perfusfind S.L.

Abstract Background and Aims Adults with congenital heart disease tend to develop both cardiac and noncardiac age-related comorbidities earlier in life than the general population, suggesting accelerated biological ageing. Epigenetic clocks estimate biological age based on DNA methylation profiles. This study investigated whether adults with congenital heart disease display accelerated..

Perfusfind S.L.

Abstract Objectives To identify risk factors associated with inadequate heparin response in pediatric congenital heart surgery requiring cardiopulmonary bypass and to develop age-specific predictive scoring systems. Design Retrospective cohort study. Setting Tertiary medical center. Participants Pediatric patients (age <18 years) undergoing congenital heart surgery on cardiopulmonary bypass between December 2022..

Perfusfind S.L.

Abstract Congenital heart disease (CHD) is the most common congenital anomaly worldwide and is associated with substantial infant morbidity and mortality. This narrative review synthesizes evidence linking CHD to alterations in the gut microbiome across neonatal, perioperative, and chronic stages and highlights a gut–heart–immune framework in which microbial imbalance, intestinal..

Perfusfind S.L.

Abstract Importance  Neurodevelopmental impairments are common in children with congenital heart disease. Objectives  To compare neurodevelopmental outcomes by cardiac diagnosis and identify associations between medical and social factors and early neurodevelopmental outcomes among children with congenital heart disease. Design, Setting, and Participants  This cross-sectional analysis used neurodevelopmental follow-up data obtained between May 1,..