Pediatric

Perfusfind S.L.

Abstract Purpose Pediatric patients undergoing cardiac surgery are at risk of developing postoperative acute kidney injury (AKI). We hypothesized that a reduction in intraoperative renal (SrO2) or cerebral (ScO2) tissue oxygen saturation is associated with postoperative AKI. Methods We conducted a prospective observational study including fifty pediatric patients with non-cyanotic..

Perfusfind S.L.

Abstract Background We implemented a preoperative screening brain magnetic resonance imaging (MRI) protocol for neonates undergoing cardiac surgery. The intent was to identify unrecognized central nervous system (CNS) injury that might alter the timing or type of surgical intervention. Methods This retrospective study included 397 neonates who underwent cardiac surgery..

Perfusfind S.L.

Abstract Background: Sanguineous preparation of the cardiopulmonary bypass (CPB) circuit with allogeneic blood products is known to contain substantial complement mediator burden. This study aims to assess the longitudinal immunologic impacts during pediatric CPB.    Methods: In this post-hoc analysis of a prospective observational cohort study, 40 pediatric patients undergoing cardiac surgery..

Perfusfind S.L.

Abstract Antegrade cerebral perfusion (ACP) and hypothermia are widely used neuroprotective strategies during neonatal aortic arch repairs. Still, over 50% of neonates exhibit new or worsened white matter injury in neuroimaging studies. Currently, clinical practices differ markedly, and we lack consensus about optimal ACP perfusion and temperature strategies. This review..

Perfusfind S.L.

Abstract Background: A 17-year-old male patient diagnosed with a single ventricle, in a failed Fontan stage, was evaluated prior to heart transplantation. The patient had a panel-reactive antibody (PRA) for human leucocyte antigen (HLA) I of 18% and for HLA II of 37%, so the decision was made to administer..

Perfusfind S.L.

Abstract Background Intraoperative sodium changes and new postoperative white matter injury are prevalent in neonates with congenital heart disease (CHD) who undergo cardiopulmonary bypass surgery. Rapid sodium correction in hyponatremia is associated with white matter injury in adults. This study examined the potential effects of a rapid intraoperative sodium increase..

Perfusfind S.L.

Abstract Introduction: The absence of a congenital heart surgery national registry limits understanding of access, surgical volume, and mortality. This study analyzes the Brazilian administrative data to assess procedural distribution, outcomes, and regional disparities in congenital heart surgery.  Methods: Retrospective analysis of the National Database (SIH/SUS) via DATASUS from January 2019 to..

Perfusfind S.L.

Abstract Hereditary spherocytosis (HS) is a rare inherited haemolytic anaemia. This case report outlines a neonatal patient with presumed HS requiring cardiopulmonary bypass (CPB) and the whole blood exchange transfusion carried out in the immediate pre bypass setting to ensure a successful outcome.

Perfusfind S.L.

Abstract Introduction Post-CPB bleeding remains a critical challenge in neonatal cardiac surgery, and early detection of coagulopathy to guide transfusion decisions may offer significant benefits. We hypothesized that routine use of intraoperative ROTEM as a decision parameter would reduce perioperative transfusions, modulate transfusion patterns and improve the outcomes in newborns..

Perfusfind S.L.

Abstract Excessive right heart load imposes an acute or chronic injury on the right ventricle (RV), predisposing critically ill neonates and cardiac surgical patients to RV failure, low cardiac output syndrome, and death. Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator that improves ventilation–perfusion matching and unloads the RV..