Pediatric

Perfusfind S.L.

Abstract Background Cardiopulmonary bypass is associated with systemic inflammation during pediatric cardiac surgery and features elevated systemic concentrations of complement, cytokines and chemokines. The objective of this study is to quantify the immunologic efficacy of ultrafiltration (UF) used continuously throughout CPB. Methods Pediatric patients were enrolled in a single-arm prospective..

Perfusfind S.L.

Abstract Background Brain development is altered in neonates with congenital heart disease (CHD), with well-characterised reductions in regional brain volumes and enlargement of CSF spaces. However, perioperative morphological changes remain incompletely understood. Purpose To identify brain regions showing spatial patterns of coordinated expansion and contraction that differ between neonates with..

Perfusfind S.L.

Abstract Objectives The hemostatic system in neonates and infants with congenital heart disease is distinct as a result of developmental and disease-specific factors, necessitating population-specific periprocedural evaluation and antithrombotic management. Ongoing practice variation reflects limited evidence and highlights the need for structured guidance and further study. Methods To develop a..

Perfusfind S.L.

Abstract Purpose To evaluate changes in post-operative transfusion requirements of infants undergoing congenital diaphragmatic hernia (CDH) repair on ECMO following implementation of a perioperative guideline. Methods In 2021, a multidisciplinary team created a guideline for perioperative management of CDH repair on ECMO, including guidance on pre-operative lab values, antifibrinolytic dosing,..

Perfusfind S.L.

Abstract Objectives Cardiopulmonary bypass is necessary for surgical repair of complex congenital heart disease. We studied whether whole blood use in circuit prime and for initial intraoperative transfusion needs improved postoperative outcomes in infants less than 2 months of age. Methods This was a single-center retrospective chart review of infants..

Perfusfind S.L.

Abstract Background: Among infants undergoing cardiac surgery, AKI may affect as many as 40% of this population and carries an unfavorable prognosis. A range of contributors has been implicated, including early age, cyanotic physiology, and extended time on cardiopulmonary bypass (CPB). Nadir-indexed oxygen delivery (DO2) is an important determinant for early..

Perfusfind S.L.

Abstract BACKGROUND We sought to determine if modified ultrafiltration (MUF) in the current era was associated with improved outcomes after neonatal cardiopulmonary bypass (CPB). METHODS Retrospective analysis of the PC4/NEPHRON dataset from 22 centers (2015-18). Neonates were stratified by MUF use and outcomes were compared. Multivariable regression models were adjusted..

Perfusfind S.L.

Abstract Lactate clearance is a key marker of oxygen delivery after neonatal cardiac surgery. While higher hematocrit (HCT) is often targeted to optimize oxygen delivery, its relationship with postoperative lactate clearance remains unclear. We hypothesized that supraphysiologic initial HCT may decrease lactate clearance. To assess whether higher initial postoperative HCT..

Perfusfind S.L.

      Dr.Sam Zeraatian Nejad Davani,  Cardiovascular and Thoracic Surgeon Transplant and Thoracic Organs Recovery Surgeon.  Director of Georgia Atlanta Procure on Demand Thoracic Organs Transplant and Procurement Surgery.                      

Perfusfind S.L.

Abstract Introduction Congenital Heart Disease (CHD) remains a major health challenge globally, with surgical interventions being the primary treatment modality for many defects. While advancements in cardiac surgery have improved survival rates, early postoperative complications continue to pose risks, particularly in settings with limited resources like Kenya. The study aimed..