Pediatric

Perfusfind S.L.

Abstract Effective perioperative hemostasis in pediatric cardiac surgery depends not only on accurate diagnostics and targeted transfusion strategies but also on a clear and consistent definition of postoperative bleeding. Despite the clinical importance of bleeding in neonates and children undergoing cardiopulmonary bypass, bleeding remains variably defined across institutions, registries, and..

Perfusfind S.L.

Abstract Aim Congenital heart disease still has significant morbidity and mortality despite advances in surgery. Inadequate tissue perfusion is thought to be the primary cause. Monitoring children with cerebral oxygenation with near infrared spectroscopy before and after surgery may predict pre- and post-operative mortality. This study evaluated the benefits of..

Perfusfind S.L.

Abstract Background: Pediatric cardiac surgery is still a high-risk procedure, with mortality being a significant concern. Lactate clearance has been demonstrated to enhance outcomes in critically ill adult populations; however, data regarding its significance in the context of pediatric cardiac surgery has been limited, particularly in resource-limited settings like Nepal. The..

Perfusfind S.L.

Abstract Background Congenital heart disease (CHD) remains a leading cause of pediatric morbidity and mortality worldwide. Cardiopulmonary bypass (CPB) is crucial for surgical repair but is associated with systemic inflammation and/or end-organ dysfunction. Ultrafiltration (UF) techniques, particularly zero-balance ultrafiltration (Z-BUF), have been developed to mitigate these effects by removing cytokines...

Perfusfind S.L.

Abstract As adult programs of newer anthrombotic agents, such as those directed against FXIa, are underway, there is both a pressing need and a great opportunity to optimize the design, conduct, and analysis of future pediatric trials. Recommendations for the development of new anticoagulation drugs for pediatric use were last..

Perfusfind S.L.

Abstract Congenital heart disease often requires early surgical intervention. Cardiopulmonary bypass (CPB) is a standard procedure, but infants undergoing CPB show an increased risk of postoperative white matter injury. These injuries are associated with adverse neurodevelopmental outcomes, yet the underlying mechanisms remain poorly understood. MR imaging offers unique opportunities to..

Perfusfind S.L.

Abstract Background Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory paediatric in-hospital cardiac arrest (IHCA). Although rapid initiation of extracorporeal life support (ECLS) is widely considered critical, the relative contributions of cannulation timing and early physiologic recovery to survival outcomes remain incompletely defined. Methods We conducted a retrospective cohort..

Perfusfind S.L.

Abstract Extracorporeal cardiopulmonary resuscitation (ECPR) for pediatric cardiac arrest relies on enhanced resources and time-critical decision-making. We aimed to evaluate variations in systems and clinical practice among extracorporeal membrane oxygenation (ECMO) centers that offer ECPR for neonatal and pediatric patients using an online survey. Fifty-three ECMO centers participated, representing all..

Perfusfind S.L.

Abstract Objectives Neonates and infants who receive a Ross or Ross-Konno operation form a different population from older children and adults who undergo this procedure. We aimed to provide a contemporary reassessment of the procedure in patients younger than 1 year of age. Methods We conducted a retrospective, observational multicentre..

Perfusfind S.L.

Abstract During cerebral ischemia, the quantitative Electroencephalogram (EEG) Alpha: Delta Ratio (ADR) decreases, and the asymmetry percentage increases. The utility of analyzing these metrics during neonatal Antegrade Cerebral Perfusion (ACP) or Deep Hypothermic Circulatory Arrest (DHCA), and whether significant EEG changes precede neurologic injury after pediatric cardiac surgery, remains unknown...