Ventilator-associated pneumonia: mechanisms, an appraisal of current therapies and the role for inhaled antibiotics in prevention and treatment
Summary Ventilator-associated pneumonia (VAP), the most common healthcare-associated infection in the ICU, significantly increases healthcare costs and negatively impacts patient outcomes. The review outlines complex VAP pathophysiology, involving abnormal microbiota colonization and micro-aspiration associated with mechanical ventilation. Traditional intravenous antibiotic therapies face challenges such as systemic complications and antibiotic resistance, while inhaled antibiotics offer a […]