septic shock archivos - Perfusfind Intensive Care

Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised…

Abstract: Endo et al. conducted the OPTPRESS trial, a multicenter randomized controlled trial in Japan, evaluating whether a higher mean arterial pressure (MAP) target (80–85 mmHg) reduces mortality in older patients (≥65 years) with septic shock compared to standard targets (65–70 mmHg). The trial was terminated early due to increased mortality and adverse events in […]

Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised… Read Post »

Sepsis

Metabolic septic shock sub-phenotypes, stability over time and association with clinical outcome

Summary of Metabolic Septic Shock Sub-Phenotypes, Stability Over Time and Association with Clinical Outcome Abstract Summary: Antcliffe et al. examined metabolic sub-phenotypes in septic shock using metabolomic data from two clinical trials (LeoPARDS and VANISH). They identified three distinct metabolic clusters, primarily characterized by lipid metabolite levels, especially lysophospholipids. Persistence in low lysophospholipid clusters correlated

phenotypes, sepsis, septic shock

Metabolic septic shock sub-phenotypes, stability over time and association with clinical outcome Read Post »

Miscellaneous, Sepsis

How I personalize fluid therapy in septic shock?

Abstract During septic shock, fluid therapy is aimed at increasing cardiac output and improving tissue oxygenation, but it poses two problems: it has inconsistent and transient efficacy, and it has many well-documented deleterious effects. We suggest that there is a place for its personalization according to the patient characteristics and the clinical situation, at all

Cardiac output, Fluid balance, fluid challenge, fluid therapy, septic shock, Tidal volume, Volume expansion

How I personalize fluid therapy in septic shock? Read Post »

Sepsis

Current perspectives in the management of sepsis and septic shock

Abstract Within patients with sepsis, there exists significant heterogeneity, and while all patients should receive conventional therapy, there are subgroups of patients who may benefit from specific therapies, often referred to as rescue therapies. Therefore, the identification of these specific patient subgroups is crucial and lays the groundwork for the application of precision medicine based

cytokine storm, hemoadsorption, personalized treatment, sepsis, septic shock

Current perspectives in the management of sepsis and septic shock Read Post »

Pharmacological Insights in Critical Care, Sepsis

Ivabradine in Septic Shock: A Narrative Review

Abstract In patients with septic shock, compensatory tachycardia initially serves to maintain adequate cardiac output and tissue oxygenation but may persist despite appropriate fluid and vasopressor resuscitation. This sustained elevation in heart rate and altered heart rate variability, indicative of autonomic dysfunction, is a well-established independent predictor of adverse outcomes in critical illness. Elevated heart

cardiac dysfunction, Ivabradine, multiple organ disfunction syndrome, septic cardiomyopathy, septic shock, β-blockers

Ivabradine in Septic Shock: A Narrative Review Read Post »

Sepsis

The role of peripheral perfusion markers and lactate in septic shock resuscitation

Abstract Septic shock leads to progressive hypoperfusion and tissue hypoxia. Unfortunately, numerous uncertainties exist around the best monitoring strategy, as available techniques are mere surrogates for these phenomena. Nevertheless, central venous oxygen saturation (ScvO2), venous-to-arterial CO2 gap, and lactate normalization have been fostered as resuscitation targets for septic shock. Moreover, recent evidence has challenged the central role of lactate. Following

Capillary refill time, lactate, septic shock

The role of peripheral perfusion markers and lactate in septic shock resuscitation Read Post »

Sepsis

Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials

Abstract Background Treatment with short-acting betablockers in septic patients remains controversial. Two recent large multicenter trials have provided additional evidence on this therapeutic approach. We thus performed a meta-analysis, including the most recent data, to evaluate the potential impacts of treatment with short-acting betablockers on mortality in adult septic patients. Methods The data search included

Betablocker, Esmolol, Landiolol, mortality, sepsis, septic shock

Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials Read Post »

Sepsis

Epidemiology of β-blocker use among critically iII patients during and after septic shock

Abstract Introduction β-Blockers are used widely in the outpatient care of chronic disease, but less is known about how to restart chronic therapy during and after hospitalization for septic shock [1, 2]. We sought to characterize the epidemiology of β-blocker treatment during and after septic shock among patients administered chronic β-blocker therapy in the year

septic shock, β-blocker

Epidemiology of β-blocker use among critically iII patients during and after septic shock Read Post »