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Miscellaneous

The Predictive Validity of the Full Outline of UnResponsiveness Score Compared to the Glasgow Coma Scale in the Intensive Care Unit: A Systematic Review

Abstract   The Full Outline of UnResponsiveness (FOUR) score was developed to overcome the limitations of the Glasgow Coma Scale (GCS) when assessing individuals with impaired consciousness. We sought to review the evidence regarding the predictive validity of the GCS and FOUR score in intensive care unit (ICU) settings. This review was prospectively registered in […]

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The Predictive Validity of the Full Outline of UnResponsiveness Score Compared to the Glasgow Coma Scale in the Intensive Care Unit: A Systematic Review Read Post »

Sepsis

Investigating computational models for diagnosis and prognosis of sepsis based on clinical parameters: Opportunities, challenges, and future research directions

  Abstract This study investigates the use of computational frameworks for sepsis. We consider two dimensions for investigation – early diagnosis of sepsis (EDS) and mortality prediction rate for sepsis patients (MPS). We concentrate on the clinical parameters on which sepsis diagnosis and prognosis are currently done, including customized treatment plans based on historical data of

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Investigating computational models for diagnosis and prognosis of sepsis based on clinical parameters: Opportunities, challenges, and future research directions Read Post »

Sepsis

Do prolonged infusions of β-lactam antibiotics improve outcomes in critically ill patients with sepsis? It is time to say yes

Abstract Sepsis remains an important global health problem and a leading cause of death in critically ill patients worldwide [1]. The β-lactam antibiotics are widely used as an important component of antibiotic therapy for patients with sepsis. The bactericidal activity of β-lactam antibiotics is typically time-dependent, and their clinical effectiveness is affected by the duration

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Do prolonged infusions of β-lactam antibiotics improve outcomes in critically ill patients with sepsis? It is time to say yes Read Post »

Miscellaneous

Rethinking energy and protein provision for critically ill patients

Abstract Guidelines informing energy and protein doses for critically ill patients are based largely on low-quality evidence and expert consensus recommendations [1, 2], but more recent randomized controlled trials (RCTs) have provided new data. Thus, we summarize here the current evidence base and provide advice concerning energy and protein provision during critical illness. Conclusions In critically

Rethinking energy and protein provision for critically ill patients Read Post »

Respiratory

Management of life-threatening hemoptysis

Abstract It is estimated that 5–14% of patients presenting with hemoptysis will have life-threatening hemoptysis, with a reported mortality rate between 9 and 38%. This manuscript provides a comprehensive literature review on life-threatening hemoptysis, including the etiology and mechanisms, initial stabilization, and management of patients. There is no consensus on the optimal diagnostic approach to

Management of life-threatening hemoptysis Read Post »

Respiratory

Effectiveness of antenatal dexamethasone in reducing respiratory distress syndrome and mortality in preterm neonates: a nested case control study

Abstract   Background Respiratory distress syndrome (RDS) is a significant cause of preterm neonatal morbidity and mortality globally. Measures like the use of antenatal corticosteroids (ACS) and immediate resuscitation of the newborn after birth are taken to abate preterm related complications. Most studies that evidenced the benefit of ACS were done in high resource settings.

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Effectiveness of antenatal dexamethasone in reducing respiratory distress syndrome and mortality in preterm neonates: a nested case control study Read Post »

Circulatory

Left Ventricular Assist Devices

Objective The objective of this health technology policy assessment was to determine the effectiveness and cost-effectiveness of using implantable ventricular assist devices in the treatment of end-stage heart failure. Heart Failure Heart failure is a complex syndrome that impairs the ability of the heart to maintain adequate blood circulation, resulting in multiorgan abnormalities and, eventually,

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Left Ventricular Assist Devices Read Post »

Mechanical Ventilation

Stepwise Ventilator Waveform Assessment to Diagnose Pulmonary Pathophysiology

Electronically displayed ventilator waveforms provide a wealth of insight into the physiology of the respiratory system. Pressure and flow values can be independent variables that reflect control by the ventilator or dependent variables that demonstrate the respiratory system’s response to mechanical ventilation. Diagrams of time-based pressure and flow curves may reveal underlying pathophysiology beyond more

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Stepwise Ventilator Waveform Assessment to Diagnose Pulmonary Pathophysiology Read Post »

Circulatory

Extracorporeal cardiopulmonary resuscitation versus conventional cardiopulmonary resuscitation in adults with cardiac arrest: a comparative meta-analysis and trial sequential analysis

Summary   Background Although outcomes of patients after cardiac arrest remain poor, studies have suggested that extracorporeal cardiopulmonary resuscitation (ECPR) might improve survival and neurological outcomes. We aimed to investigate any potential benefits of using ECPR over conventional cardiopulmonary resuscitation (CCPR) in patients with out-of-hospital cardiac arrest (OHCA) and in-hospital cardiac arrest (IHCA).   Methods

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Extracorporeal cardiopulmonary resuscitation versus conventional cardiopulmonary resuscitation in adults with cardiac arrest: a comparative meta-analysis and trial sequential analysis Read Post »

Circulatory

HeartMate III Autonomy Assistant in a Hemiplegic Left Ventricular Assist Device Patient: A Case Report

Abstract Terminal heart failure presents challenges, requiring cardiac transplantation, or mechanical circulatory support. Limited donor organ availability has made mechanical support crucial. Advances in centrifugal-flow systems, compared to axial-flow, have improved patient outcomes by reducing adverse events. Rehabilitation is vital for patient independence postimplantation. We developed a tool to aid hemiplegic patients in managing power

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HeartMate III Autonomy Assistant in a Hemiplegic Left Ventricular Assist Device Patient: A Case Report Read Post »

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