The metabolic response to stress in critical illness: updated review on the pathophysiological mechanisms, consequences, and therapeutic implications
Why this article matters Critical illness triggers a profound, highly coordinated metabolic stress response that extends far beyond “hypercatabolism.” This comprehensive review reframes how we understand energy metabolism, nutrition, endocrine signaling, immune function, and recovery across the acute, subacute, and chronic phases of critical illness. Importantly, it challenges long-standing assumptions around “early full feeding” and […]
