Abstract With the large volume of data coming from implemented technologies and monitoring systems, intensive care units (ICUs) represent a key area for artificial intelligence (AI) application. Despite the last decade has been marked by studies focused on the use of AI in medicine, its application in mechanical ventilation management is still limited. Optimizing […]
Abstract Background Ventilator weaning is of great importance for intensive care patients in order to avoid complications caused by prolonged ventilation. However, not all patients succeed in weaning immediately. Their spontaneous breathing may be insufficient, resulting in extubation failure and the subsequent need for reintubation. To identify patients at high risk for weaning failure, a
Abstract Injury to the spleen is one of the most common solid organ injuries in blunt trauma1. Following the primary and secondary survey in an injured patient, the potential dynamic alteration in the event of ongoing haemorrhage should be kept in mind. A sick patient should be in the operating theatre unless response to resuscitation
Splenic injury from blunt trauma Read Post »
Abstract A connection between diabetes and an increased risk of epilepsy has been suggested by observational studies. Animal studies have also shown that antihyperglycemic drugs can improve seizures. However, it is unclear whether antihyperglycemic drugs have a causal role in epilepsy in humans. To investigate this potential causal relationship, a Mendelian randomisation study was
Abstract The Full Outline of UnResponsiveness (FOUR) score was developed to overcome the limitations of the Glasgow Coma Scale (GCS) when assessing individuals with impaired consciousness. We sought to review the evidence regarding the predictive validity of the GCS and FOUR score in intensive care unit (ICU) settings. This review was prospectively registered in
Abstract This study investigates the use of computational frameworks for sepsis. We consider two dimensions for investigation – early diagnosis of sepsis (EDS) and mortality prediction rate for sepsis patients (MPS). We concentrate on the clinical parameters on which sepsis diagnosis and prognosis are currently done, including customized treatment plans based on historical data of
Abstract Sepsis remains an important global health problem and a leading cause of death in critically ill patients worldwide [1]. The β-lactam antibiotics are widely used as an important component of antibiotic therapy for patients with sepsis. The bactericidal activity of β-lactam antibiotics is typically time-dependent, and their clinical effectiveness is affected by the duration
Abstract Guidelines informing energy and protein doses for critically ill patients are based largely on low-quality evidence and expert consensus recommendations [1, 2], but more recent randomized controlled trials (RCTs) have provided new data. Thus, we summarize here the current evidence base and provide advice concerning energy and protein provision during critical illness. Conclusions In critically
Rethinking energy and protein provision for critically ill patients Read Post »
Abstract It is estimated that 5–14% of patients presenting with hemoptysis will have life-threatening hemoptysis, with a reported mortality rate between 9 and 38%. This manuscript provides a comprehensive literature review on life-threatening hemoptysis, including the etiology and mechanisms, initial stabilization, and management of patients. There is no consensus on the optimal diagnostic approach to
Management of life-threatening hemoptysis Read Post »