Tags Archives: heparin

Perfusfind S.L.

Abstract Objectives To quantify the incidence of Quantra QPlus clot time ratio (CTR) elevation (>1.4) in cardiac surgical patients with suspected postoperative coagulopathy and to investigate the correlation between CTR..

Perfusfind S.L.

Abstract Objectives To evaluate postoperative residual and reappearing heparin activity after low-dose, titration-guided protamine reversal following cardiopulmonary bypass (CPB) in elective coronary artery bypass grafting (CABG). Design Prospective, controlled clinical..

Perfusfind S.L.

Abstract A critical aspect of cardiopulmonary bypass (CPB) is achieving full anticoagulation to prevent thrombosis and consumptive coagulation (CCA). Systemic anticoagulation with heparin during CPB should be completely neutralized by..

Perfusfind S.L.

Abstract Objectives To identify risk factors associated with inadequate heparin response in pediatric congenital heart surgery requiring cardiopulmonary bypass and to develop age-specific predictive scoring systems. Design Retrospective cohort study...

Perfusfind S.L.

Abstract Background: Heparin-induced thrombocytopenia (HIT) in patients who undergo cardiac surgery presents unique diagnostic and management challenges due to universal perioperative heparin exposure, postoperative platelet kinetics, and the high prevalence..

Perfusfind S.L.

Abstract Objectives To compare the diagnostic performance of 4 clinical prediction scores for heparin-induced thrombocytopenia (HIT) in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Design Bicentric retrospective observational study...

Perfusfind S.L.

Abstract Objectives This systematic review and meta-analysis aimed to evaluate clinical outcomes associated with different systemic heparin protocols (conservative v standard intensity) during extracorporeal membrane oxygenation (ECMO) support. Included studies comprised both..

Perfusfind S.L.

Abstract Objectives Hemorrhagic complications remain a major concern in patients with cardiogenic shock and extracorporeal cardiopulmonary resuscitation. The purpose of this study was to assess the effect of withholding a..

Perfusfind S.L.

Abstract Background Monitoring of unfractionated heparin (UFH) in critically ill patients is challenging due to disease-related alterations of the coagulation system, directly affecting conventional laboratory tests, including activated partial thromboplastin..

Perfusfind S.L.

Abstract Introduction Regional citrate anticoagulation (RCA) is the recommended first-line strategy for continuous renal replacement therapy (CRRT) circuits. Acute kidney injury is common in patients undergoing venoarterial extracorporeal membrane oxygenation..

Perfusfind S.L.

Abstract Heparin is among the most widely used anticoagulants worldwide, with an annual market of ∼$4 billion. It also poses potential bleeding risks (0.5–5%), occasionally life-threatening, necessitating heparin reversal agents...

Perfusfind S.L.

Abstract Background: Andexanet alfa, a Gla-domainless mutant factor Xa (GDXa), reverses oral FXa inhibitors but can cause severe heparin resistance during cardiopulmonary bypass (CPB). Antithrombin (AT) supplementation may mitigate this..

Perfusfind S.L.

Abstract Background and Aims To date, thromboelastometry has not been investigated as an assay to monitor profound heparin anticoagulation, such as is required for a safe cardiopulmonary bypass (CPB). The..

Perfusfind S.L.

Abstract Background Controversies exist in anticoagulation practices in extracorporeal membrane oxygenation (ECMO). It is uncertain whether the intensity of anticoagulation affects ECMO outcomes. Objectives To conduct a meta-analysis to determine..

Perfusfind S.L.

Abstract This chapter provides an overview of heparin, including discovery, structure, mechanism of action, and principal use for anticoagulation. For over 100 years, heparin has a central role in prophylaxis..

Perfusfind S.L.

Abstract The activated partial thromboplastin time (APTT) assay is essential for evaluating coagulation. However, prolonged APTT may result from pathological conditions or contamination with unfractionated heparin (UFH), which can occur..

Perfusfind S.L.

Abstract Background: Unfractionated heparin (UFH) is the standard anticoagulant during cardiopulmonary bypass (CPB). A clinically relevant subset develops heparin resistance (HR)—failure to reach adequate anticoagulation with usual UFH—raising thrombotic risk..

Perfusfind S.L.

Abstract Heparin is the primary anticoagulant used for cardiopulmonary bypass and requires reversal to prevent postoperative bleeding. Protamine sulfate is the only United States Food and Drug Administration–approved heparin reversal..

Perfusfind S.L.

Abstract Background: Unfractionated heparin (UFH) is the standard anticoagulant during cardiopulmonary bypass (CPB). A clinically relevant subset develops heparin resistance (HR)—failure to reach adequate anticoagulation with usual UFH—raising thrombotic risk..

Perfusfind S.L.

Abstract Unfractionated heparin has long been the conventional anticoagulant for pediatric mechanical circulatory support (MCS). As bivalirudin has gained traction in ventricular assist devices (VAD) management, its role in extracorporeal..

Perfusfind S.L.

Abstract Transfusion management during cardiac surgery is commonly guided by algorithms using viscoelastic tests such as Rotational Thromboelastometry (ROTEM). Recently, the ROTEM Sigma, a new device developed as a fully..

Perfusfind S.L.

Abstract Objective Overdiagnosis occurs when abnormalities meeting diagnostic criteria would remain asymptomatic if undiagnosed. Cases initially identified through digital diagnostic tools but later recognised as overdiagnosis are referred to as..

Perfusfind S.L.

Abstract Extracorporeal membrane oxygenation (ECMO) is a mechanical circulatory and respiratory support system that facilitates gas exchange and hemodynamic stabilization through an external circuit. ECMO has been increasingly utilized for..

Perfusfind S.L.

Abstract Objectives Residual heparinization is a preventable cause of coagulopathy following cardiac surgery. The aim of this work was to assess the proportion of patients with residual heparinization following cardiac..

Perfusfind S.L.

Abstract Background: In cardiac surgery, protamine is used to reverse the effects of heparin after separation from cardiopulmonary bypass (CPB). Excess of protamine has been demonstrated to cause platelet dysfunction and..

Perfusfind S.L.

Abstract In blood extracorporeal circulations such as hemodialysis (HD) and extracorporeal membrane artificial lung (ECMO) during the surgical operation, the real-time and noninvasive prediction of heparin concentration c is necessary over the..

Perfusfind S.L.

Abstract Objectives The detection of low-range heparin activity is important to correctly assess heparin reversal and rebound, especially after cardiopulmonary bypass. Current parameters are either not available at point-of-care (anti-Xa..

Perfusfind S.L.

Abstract Introduction The recently recommended activated clotting time (ACT) to be maintained at the initiation of and during cardiopulmonary bypass (CPB) is ≥480 s. However, the post-unfractionated heparin (UFH) administration ACT..

Perfusfind S.L.

Abstract Introduction There is no consensus on the dose of heparin to be used intraoperatively in cardiac myxomas, so the goal of this study was to look into the differences..

Perfusfind S.L.

Abstract The term heparin resistance is likely best defined as the failure of an appropriate dose of unfractionated heparin (UFH) to achieve a predetermined level of anticoagulation. Unfortunately, and despite..