Pharmacology

Pharmacological Insights in Critical Care

Role of liposomal amphotericin B in intensive care unit: an expert opinion paper

Summary of Role of Liposomal Amphotericin B in Intensive Care Unit: An Expert Opinion Paper (Bussini et al.) Abstract Summary: Bussini et al. provide an expert opinion on the appropriate clinical use of Liposomal Amphotericin B (L-AmB) in treating invasive fungal infections (IFI) within the intensive care unit (ICU). The authors detail the limitations of […]

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Pharmacological Insights in Critical Care

Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study

Abstract Purpose Appropriate antifungal therapy is a major determinant of survival in critically ill patients with invasive fungal disease. We sought to describe whether contemporary dosing of antifungals achieves therapeutic exposures in critically ill patients. Methods In a prospective, open-label, multicenter pharmacokinetic study, intensive care unit (ICU) patients prescribed azoles, echinocandins, or polyene antifungals for

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Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study Read Post »

Pharmacological Insights in Critical Care

Knowing the ropes of vasopressor dosing: a focus on norepinephrine

Summary of “Knowing the Ropes of Vasopressor Dosing: A Focus on Norepinephrine” Abstract Summary: This editorial discusses the pharmacological properties, dosing strategies, and clinical considerations for norepinephrine, the first-line vasopressor in managing shock. It highlights the complexities of dosing in critically ill patients, variability in pharmacodynamics, and the need for individualized therapy. The authors emphasize

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