Pharmacological Insights in Critical Care

Artificial Intelligence, Mechanical Ventilation, Pharmacological Insights in Critical Care, Respiratory

Barotrauma: The statistical fallacy. A non-conventional scoping review with Bayesian meta-analysis

Abstract Background Mechanical ventilator-associated damage has a high relevance in the clinical outcomes of critically ill patients. Barotrauma is a colloquial premise that has not been questioned, while other concepts such as mechanotransduction based on time-dependent viscoelastic models derived from materials engineering and physics appear as a more solid and clinically plausible postulate. This scoping […]

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Circulatory, Mechanical Ventilation, Pharmacological Insights in Critical Care

Ventilation and Oxygenation During and After Adult Cardiopulmonary Resuscitation: Changing Paradigms

Abstract Cardiac arrest (CA) remains a major cause of death despite advancements in cardiopulmonary resuscitation (CPR), post-resuscitation care, and international efforts to develop evidence-based guidelines. Effectively managing ventilation and oxygenation during and after CPR is vital for patient survival and neurological outcomes, yet it remains a challenging task. This review examines current strategies for ventilation

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Mechanical Ventilation, Pharmacological Insights in Critical Care

Pressure support, patient effort and tidal volume: a conceptual model for a non linear interaction

Abstract Pressure support ventilation (PSV) is a form of assisted ventilation which has become frequently used, with the aim of partially unloading the patient’s inspiratory muscles. Both under- and over-assistance should be avoided to target a lung- and diaphragm- protective ventilation. Herein, we propose a conceptual model, supported by actual data, to describe how patient

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Pharmacological Insights in Critical Care

Knowing the ropes of vasopressor dosing: a focus on norepinephrine

Summary of “Knowing the Ropes of Vasopressor Dosing: A Focus on Norepinephrine” Abstract Summary: This editorial discusses the pharmacological properties, dosing strategies, and clinical considerations for norepinephrine, the first-line vasopressor in managing shock. It highlights the complexities of dosing in critically ill patients, variability in pharmacodynamics, and the need for individualized therapy. The authors emphasize

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