August 2025

Mechanical Ventilation

Neurally adjusted ventilatory assist in critical care patients with and without obesity: a prospective randomized crossover study

đŸ« NAVA vs PSV in Obese ICU Patients: First Evidence of Safety and Benefit   Abstract: This randomized crossover study is the first to test Neurally Adjusted Ventilatory Assist (NAVA) in critically ill obese patients. Twenty-one ventilated patients (10 obese, 11 non-obese) underwent 30 minutes of NAVA and PSV each. Researchers assessed safety, patient-ventilator synchrony, […]

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Sepsis

Biomarkers to guide sepsis management

🧬 Biomarkers to Guide Sepsis Management: The Next Frontier Abstract: Sepsis remains a leading global cause of mortality and morbidity. This review highlights how biomarkers—from inflammatory mediators to endothelial and immune markers—are increasingly being used to guide key elements of sepsis management: early diagnosis, antibiotic stewardship, fluid therapy, vasopressor initiation, and immunotherapy. Precision therapeutics anchored

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Pulmonary

Hyperoxia and acute brain injury

🧠 Hyperoxia in Acute Brain Injury: Friend or Foe? Abstract: This commentary responds to Romero-García et al.’s meta-analysis linking arterial hyperoxemia (PaO₂ elevation) to worse neurological outcomes in acute brain injury (ABI). The authors argue that equating hyperoxemia with cellular hyperoxia and oxidative injury is an oversimplification. Physiological evidence shows that oxygen transport is constrained

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Respiratory, Uncategorized

Imaging and pulmonary function techniques in ARDS diagnosis and management: current insights and challenges

đŸ« Are CT, LUS, and EIT the missing link to truly personalized ARDS care? Abstract: This narrative review argues that integrating chest CT, lung ultrasound (LUS), and electrical impedance tomography (EIT) with key physiology (compliance, driving pressure, transpulmonary pressure, mechanical power) can sharpen ARDS diagnosis and enable more individualized ventilation. The authors endorse a tiered

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Uncategorized

Continuous versus bolus norepinephrine administration and arterial blood pressure stability during induction of general anaesthesia in high-risk noncardiac surgery patients: a randomised trial

Summary This randomized clinical trial compared the effects of continuous norepinephrine infusion versus intermittent manual bolus administration on arterial blood pressure stability during induction of general anesthesia in high-risk noncardiac surgical patients. Seventy-one patients were randomized, and blood pressure stability was measured as generalized average real variability of mean arterial pressure (ARV-MAP) during the first

Continuous versus bolus norepinephrine administration and arterial blood pressure stability during induction of general anaesthesia in high-risk noncardiac surgery patients: a randomised trial Read Post »

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