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Inflammatory Cytokines as Early Predictors of Weaning Failure From Extracorporeal Life Support

Abstract Background Weaning from extracorporeal life support (ECLS) in patients with refractory shock still remains a complex decision. Despite considerable advances in ECLS management, reliable biomarkers to predict weaning success..

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Evaluation of Cardiac Output Estimation with Veno-Venous Extracorporeal membrane Oxygenation Support: in vitro study

Abstract Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is used to treat refractory lung failure, a condition that often results in right ventricular dysfunction, which can exacerbate both morbidity and mortality...

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Extracorporeal Membrane Oxygenation for Calcium Channel Blocker Intoxication: A Multicenter Retrospective Registry Review

Abstract Calcium channel blocker (CCB) toxicity can lead to cardiogenic shock and circulatory collapse. Extracorporeal membrane oxygenation (ECMO) has been used as salvage therapy when conventional treatments fail, but outcomes..

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Bleeding Complications from Chest Tube Treatment in Patients on Extracorporeal Membrane Oxygenation Support

Abstract Objectives Bleeding is a common complication of extracorporeal membrane oxygenation (ECMO) support. While chest tube treatment is infrequently linked to bleeding in non-ECMO patients, several reports suggest a markedly..

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Crossing the line: blood transfusion thresholds in ECMO

Abstract In the high-stakes realm of extracorporeal membrane oxygenation (ECMO), every decision can have profound consequences—from initiation to termination. Management controversies persist throughout the entire course. Beyond patient selection, timing,..

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Epidemiology, outcomes, and three-year quality of life in patients supported with VV-ECMO for critical COVID-19 infection

Abstract BACKGROUND: This single center study analyzed epidemiology, outcomes, and three-year quality of life (QoL) of critically ill COVID-19 patients requiring a possibly life-saving VV-ECMO. METHODS: Demographics, clinical and technical..

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Delta-P as an early indicator of oxygenator failure: the case for standardized manufacturer reference values

Abstract The evolution of extracorporeal membrane oxygenation (ECMO) has led to an increasing reliance on objective parameters to detect complications early and enhance patient safety. One such parameter is the..

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Prognosis of Immunocompromised Patients With Respiratory Failure Managed With Venovenous Extracorporeal Membrane Oxygenation

Abstract Despite the increasing number of critically ill immunocompromised patients in intensive care unit, the outcome of different types of immunocompromised patients with respiratory failure managed with venovenous extracorporeal membrane..

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Beyond Standard Parameters: Precision Hemodynamic Monitoring in Patients on Veno-Arterial ECMO

Abstract Background: Hemodynamic management in veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is inherently complex, as extracorporeal circulation profoundly alters preload, afterload, ventriculo-arterial coupling and tissue perfusion. This review summarizes current..

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Time from mechanical ventilation initiation to venovenous extracorporeal membrane oxygenation in COVID-19: A prospective, multicentre, observational study

Abstract Background The impact of the duration of invasive mechanical ventilation (IMV) before venovenous extracorporeal membrane oxygenation (VV ECMO) on patient outcomes in COVID-19 remains unclear. Methods and setting Data..

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Levosimendan to Facilitate Weaning From ECMO in Patients With Severe Cardiogenic Shock

Abstract Importance  Levosimendan may facilitate weaning from venoarterial extracorporeal membrane oxygenation (VA-ECMO) and improve survival, but supporting evidence remains limited. Objective  To assess whether early administration of levosimendan reduces the time to..

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Extracorporeal Cardiopulmonary Resuscitation in Cardiac Arrest Associated to Neuroleptic Malignant Syndrome: A Case Report

Abstract Neuroleptic malignant syndrome (NMS) is a rare, life-threatening hypermetabolic reaction to dopamine-antagonist drugs that may progress to profound rhabdomyolysis, extreme hyperkalemia, and cardiac arrest (CA). Evidence guiding extracorporeal cardiopulmonary..

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Extracorporeal Membrane Oxygenation for Acute Respiratory Failure in a Dog

Abstract Extracorporeal membrane oxygenation (ECMO), a specialized medical technology that temporarily assumes the function of the heart and lungs, allows the body time to recover from severe respiratory failure. Although..

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Continuous EEG Monitoring and Clinical Outcomes in Patients Undergoing ECMO

Abstract Background Neurological complications during Extracorporeal membrane oxygenation (ECMO) can result in long-term cognitive deficits. This exploratory study aimed to determine the association between continuous EEG (cEEG) findings and neurological..

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Predictive Markers of Neurological Complications in Patients Treated With Extracorporeal Membrane Oxygenation

Abstract Critically ill patients rescued with extracorporeal membrane oxygenation (ECMO) are at risk for devastating complications, including stroke and intracerebral hemorrhage (ICH). Despite an appreciation of some clinical risk factors, we..

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Weaning from venovenous extracorporeal membrane oxygenation for acute respiratory failure: challenges and opportunities

Abstract Purpose of review  The process of weaning from venovenous extracorporeal membrane oxygenation (V-V ECMO) is a critical step in the recovery of patients with severe acute respiratory distress syndrome..

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Association between hyperoxia and mortality in patients undergoing extracorporeal membrane oxygenation: A systematic review and meta-analysis

Abstract Background The Association between hyperoxia and mortality in patients receiving extracorporeal membrane oxygenation (ECMO) remains controversial. This study aimed to systematically evaluate the impact of arterial hyperoxia on mortality..

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Percutaneous Versus Surgical Cannulation for Femoro-Femoral Venoarterial Extracorporeal Membrane Oxygenation: A Retrospective Cohort Study on Cannulation-Related Complications

Abstract Background Cannulation for peripheral veno-arterial extracorporeal membrane oxygenation (V-A ECMO) can lead to severe local complications. This study evaluated site-specific complications between percutaneous and surgical cannulation techniques for femoro-femoral..

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Predictive and prognostic factors for prolonged ECMO: a multicenter retrospective study

Abstract Purpose Prolonged ECMO has become more common during the COVID-19 pandemic but is associated with high resource utilization and poor outcomes. This study aimed to identify predictors of prolonged..

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Acute Kidney Injury After Extracorporeal Cardiopulmonary Resuscitation for Out-of-Hospital Cardiac Arrest

Abstract OBJECTIVES:  Acute kidney injury (AKI) occurs frequently in ICUs and is associated with poor outcomes. However, little is known about AKI in patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR) for..

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Hydrogel nanocomposite-based breathable non-adhesive coating for oxygen sensing film used within extracorporeal perfusion system

Abstract Real-time, quantitative biosensing within extracorporeal perfusion (ECP) and extracorporeal membrane oxygenation (ECMO) systems is key to advancing this life-support technology beyond the hospital setting to emergency care. Measuring and..

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Kidney & extracorporeal support interactions: a narrative review

Abstract Purpose of review  Acute kidney injury (AKI) is common in critically ill patients, especially among those with severe and advanced organ failure. The use of extracorporeal support (ECS) is..

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Combination of extracorporeal membrane oxygenation and continuous renal replacement therapy: a systematic review of the past decade (2014–2023)

Abstract Objective Extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) are often used together to treat critically ill patients. This systematic review aims to assess mortality and renal..

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The impact of arterial cannula direction in central venoarterial extracorporeal membrane oxygenation on aortic hemodynamic characteristics under various perfusion conditions

Abstract Objective To systematically evaluate the influence of cannula direction in central venoarterial extracorporeal membrane oxygenation (CVA ECMO) on aortic hemodynamics and oxygen transport through a multiparametric comparative analysis under..

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Veno-pulmonary extracorporeal membrane oxygenation for concomitant right ventricular and respiratory support: A systematic review of utilization patterns and outcomes

Abstract Background Veno-pulmonary artery extracorporeal membrane oxygenation (V-P ECMO) is a configuration of extracorporeal life support (ECLS) for patients with isolated or predominantly right ventricular (RV) failure and inadequate gas..

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Shear-induced dysregulation of haemostasis during extracorporeal membrane oxygenation: From cells to circuit

Abstract Extracorporeal membrane oxygenation (ECMO) is increasingly being utilized in critical care globally to allow for adequate oxygenation in patients with cardiac and/or respiratory failure. Unfortunately, haemostatic complications – both..

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Antithrombin Supplementation in Extracorporeal Membrane Oxygenation: A Systematic Review With Meta-Analysis

Abstract Background The Extracorporeal Life Support Organization recommends daily antithrombin monitoring and supplementation to achieve > 50%–80% activity during extracorporeal membrane oxygenation (ECMO). Evidence supporting this practice is uncertain, and whether..

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State-of-the-Art Update in Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest

Abstract ECPR Efficacy and Use: Extracorporeal cardiopulmonary resuscitation (ECPR) improves survival and neurologic outcomes in refractory out-of-hospital cardiac arrest, with global adoption and center availability expanding significantly.

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Thresholds for Transfusion Practice During ECMO Support. A Systematic Review and Network Meta-Analysis

Abstract Purpose The benefits of adopting restrictive transfusion strategies, as opposed to a liberal approach, during extracorporeal membrane oxygenation (ECMO) remain unclear. This network meta-analysis aims to determine whether a..

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Evaluation of water loss during extracorporeal membrane oxygenation

Abstract Introduction Extracorporeal membrane oxygenation (ECMO) can cause blood water loss due to insensible perspiration via oxygenators and plasma leakage. The accurate quantification of water loss is crucial for maintaining..

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