Differential oxygenation may complicate extracorporeal cardiopulmonary resuscitation (ECPR) either due to the initial pathology or subsequent lung injury. The dual circulation phenomenon inherent to peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) risks poorly oxygenated blood preferentially supplying the cerebral circulation. This may be deleterious to neurological outcomes and survival in this cohort. We describe two novel cases of parallel VV-ECMO support following ECPR, using a dual-lumen bicaval cannula to salvage severe differential hypoxemia. Decannulation of arterial support occurred at 4 and 7 days, respectively, with initial reconfiguration to high-flow VV-ECMO. This unique approach offers an attractive alternative to hybrid VAVECMO and may provide a necessary escalation following successful ECPR to facilitate neuroprotection.