Tags Archives: ecmo

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Early active normothermia versus no temperature control in a porcine model of extracorporeal cardiopulmonary resuscitation

Abstract Aim Early downward temperature drift is a common event of pre-hospital extracorporeal cardiopulmonary resuscitation (e-CPR), since prehospital extracorporeal membrane oxygenation (VA-ECMO) circuits often lack heat-exchangers. However, whether this core..

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Considerations and future challenges in managing ECMO for pediatric patients

Abstract In managing ECMO, preventing thrombus formation and hemolysis is crucial. While centrifugal pumps are increasingly used in pediatric ECMO, pumps designed for low flow range are not approved in..

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What is missing from fluid balance calculations during ECMO? Water loss from the membrane lung

Abstract Fluid administration and fluid balance are both important clinical considerations in the management of patients receiving extracorporeal membrane oxygenation (ECMO). Insufficient intravascular volume may limit the output of preload-dependent..

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Prosthetic valve thrombosis on venoarterial extracorporeal membrane oxygenation support: Risk factors and outcomes

Abstract Introduction In patients with prior valve replacement requiring venoarterial extracorporeal membrane oxygenation (VA ECMO), there is a risk of prosthetic valve thrombosis (PVT) due to intracardiac stasis. We describe..

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Bilateral radial arterial pressure concordance as a real-time bedside marker of native cardiac recovery during peripheral VA-ECMO weaning

Abstract Patients supported with peripheral femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) frequently face the challenge of determining the optimal timing for weaning trials, as no universally standardized bedside method is..

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Rehabilitation Intensity and Discharge Outcomes in Venovenous Extracorporeal Membrane Oxygenation Used as a Bridge to Recovery

Abstract Early rehabilitation during venovenous extracorporeal membrane oxygenation used as a bridge to recovery (VV ECMO–BTR) may help preserve functional capacity. We retrospectively analyzed 153 adults supported with VV ECMO–BTR..

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Lactate clearance and volume status at cannulation are associated with survival in trauma VV ECMO patients

Abstract Background Veno-venous extracorporeal membrane oxygenation (VV ECMO) is an advanced therapy for patients with respiratory failure refractory to conventional management. Volume overload and elevated lactate levels have been associated..

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ECMO for out of hospital refractory cardiac arrest in children: a retrospective multicenter analysis of a regional care program

Abstract Extracorporeal membrane oxygenation (ECMO) during cardiopulmonary resuscitation (ECPR) is a lifesaving technology that has been widely described for in-hospital cardiac arrest in children with underlying cardiac disease. However, data..

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Left ventricular unloading during VA-ECMO for refractory cardiogenic shock: a target trial emulation multicenter analysis

Abstract Background: Conflicting data exist regarding the survival benefit of mechanical left ventricular (LV) unloading in patients receiving peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock (CS). In..

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Impact of intra-aortic balloon pump support on cerebral blood flow velocity during venoarterial ECMO

Abstract Introduction Venoarterial extracorporeal membrane oxygenation (V-A ECMO) is frequently combined with intra-aortic balloon pump (IABP) support in patients with refractory cardiogenic shock. Although IABP may reduce V-A ECMO–related afterload,..

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Clinical and Functional Outcomes Following Repeat VA-ECMO in Adults: A Propensity Score–Matched Comparative Study

Abstract Background/Objectives: Evidence on outcomes after repeat VA-ECMO in adults remains limited. This study aimed to compare survival and post-discharge functional outcomes between adults requiring a second VA-ECMO run and..

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ECMO artificial intelligence: matching the model to the clinical question

Abstract One theme worth emphasizing is that “ECMO prediction” is not a single task. Some models are intended to inform decisions before cannulation, whereas others incorporate variables such as ECMO..

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Veno-arterial-venous Extracorporeal Membrane Oxygenation with a Hemoconcentrator to Manage Transfusion Associated Hyperkalemic Arrest

Abstract Liver transplantation (LT) is an established therapy for patients with end-stage liver disease. Advances in surgical technique, anesthetic management, and standardization of perioperative care have significantly improved outcomes, making..

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Comparative Performance of Oxygenators for Extracorporeal Membrane Oxygenation in Adults: A Retrospective Analysis

Abstract Extracorporeal membrane oxygenation (ECMO) is a vital therapy for patients with severe cardiac and pulmonary failure. Despite technological advances, oxygenator dysfunction remains common, yet comparative clinical data across devices..

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Extracorporeal membrane oxygenation in pediatric cardiac surgery: retrospective survival analysis

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a life-saving therapeutic modality in children. Outcome is multifactorial with debates regarding predictors of weaning success and mortality. Objective To explore predictors of..

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Immunothrombotic Dysregulation in Pediatric Patients Receiving Veno-arterial ECMO After Cardiac Surgery: Insights From Platelet Activation and T Cell Immune Profiling

Abstract Background: Numerous studies have demonstrated that both cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) are often associated with adverse outcomes or immune dysregulation when platelet counts decline during..

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Circuit-Directed Nitric Oxide in Anticoagulation-Contraindicated Adult Extracorporeal Membrane Oxygenation: A Single-Center Case Series

Abstract Oxygenator thrombosis is a major complication during extracorporeal membrane oxygenation (ECMO), but systemic anticoagulation may be contraindicated by active hemorrhage, recent surgery, intracranial injury, or severe coagulopathy. Circuit-directed nitric..

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Levosimendan During VA-ECMO for Cardiogenic Shock: An Updated Systematic Review and Meta-analysis Including the LEVOECMO Trial

Abstract Background Levosimendan is often given during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support with the intention of facilitating weaning. The available evidence, however, has been derived largely from nonrandomized studies..

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Protocol and Statistical Analysis Plan for the ECMO-Free Trial

Abstract Background Decannulation from venovenous extracorporeal membrane oxygenation (ECMO) at the earliest safe opportunity would be expected to improve patient outcomes. Currently, the manner in which clinicians liberate patients from..

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Center Experience, Learning Curves, Run Durations, and Outcomes in Venovenous Extracorporeal Membrane Oxygenation

Abstract Background The expanding availability of venovenous extracorporeal membrane oxygenation (ECMO) and the increasing frequency of prolonged ECMO runs challenge standard definitions of center experience based solely on patient counts...

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Outcomes in Obese Adult Venoarterial Extracorporeal Membrane Oxygenation: A Systematic Review

Abstract Historically, extracorporeal membrane oxygenation (ECMO) in critical illness and respiratory failure has been used cautiously in patients with morbid obesity. However, recent data show favorable mortality outcomes for higher..

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Increasing utilization of extracorporeal membrane oxygenation and its association with venous thromboembolism following lung transplant

Abstract Background Venous thromboembolism (VTE) is a common complication following lung transplantation, and perioperative extracorporeal membrane oxygenation (ECMO) use has increased substantially over time. The relationship between ECMO exposure and..

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Extracorporeal membrane oxygenation may prevent preterm cerebral atrophy in survivors of acute respiratory distress syndrome: a pilot trial

Abstract BACKGROUND: Individuals who survive acute respiratory distress syndrome (ARDS) often face prolonged cognitive impairments. Comparable consequences have been observed in chronic hypoxic conditions, like COPD and obstructive sleep apnea..

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A Structured Checklist for Bedside Rounds on Extracorporeal Membrane Oxygenation Patients

Abstract Patients supported with extracorporeal membrane oxygenation (ECMO) represent a uniquely challenging population. These patients require specific interventions, such as repeated circuit and lower extremity perfusion assessments, anticoagulation management, frequent..

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Revolutionizing Accelerated Percutaneous Initiation and Deployment of ECPR (RAPID ECPR): Single-Center Process and Outcomes

Abstract Objectives Recent randomized controlled trials comparing extracorporeal cardiopulmonary resuscitation (ECPR) with conventional cardiopulmonary resuscitation (CCPR) reveal mixed outcomes; however, current data support an association between ECPR and neurologically intact..

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Awake paediatric venovenous extracorporeal membrane oxygenation case report: Feasibility of PICUStars Liberation Bundles to achieve early mobilisation

Abstract Awake extracorporeal membrane oxygenation (aECMO) has emerged as a strategy to minimise physical and neurocognitive complications of a prolonged intensive care admission. However, the safety and implementation in critically..

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Meropenem Exposure During Extracorporeal Membrane Oxygenation: What Should Intensivists Know? A Scoping Review

Abstract Background Extracorporeal membrane oxygenation (ECMO) is increasingly used in adults with severe respiratory and/or cardiac failure. Because ECMO may alter drug pharmacokinetics (PK), optimizing antimicrobial dosing in this population..

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Mortality risk model for acute myocardial infarction complicated by cardiogenic shock: development, external validation, and exploratory application in a VA-ECMO…

Abstract Background Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) carries a high risk of in-hospital death. Randomized evidence does not support routine VA-ECMO use in unselected AMI-CS populations. Objective..

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From Pump to Neck: A Focused Review of Mechanical Complications in Extracorporeal Membrane Oxygenation (ECMO) Circuits

Abstract Extracorporeal membrane oxygenation (ECMO) is a life-saving modality, yet it carries inherent risks of device-related adverse events. This manuscript is a focused review of ECMO circuit mechanics, monitoring, and..

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Severe hyperoxia during VA-ECMO promotes oxidative stress and multi-organ injury in an experimental rat model of septic cardiomyopathy

Abstract Background Severe hyperoxia during venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been associated with adverse clinical outcomes in observational studies. However, causal evidence and optimal oxygen targets remain uncertain. Hyperoxia..

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