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The Role of Recirculation-Guided Blood Flow Adjustment in Venovenous Extracorporeal Membrane Oxygenation: A Pilot Study

Abstract Recirculation reduces the efficiency of venovenous extracorporeal membrane oxygenation (V-V ECMO), but patient-specific determinants of recirculation and the feasibility of recirculation-guided flow adjustment are not well defined. In this..

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Levosimendan for Weaning from VA-ECMO: Two Trials, Two Timings

Abstract Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used for providing adequate organ support in cardiogenic shock. While the intervention provides circulatory and respiratory support in the critical stage, it..

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Extracorporeal Life Support Use During Severe Anaphylaxis: A Systematic Review and Pooled Analysis of Individual Patient Data

Abstract Objective Severe anaphylaxis is a rare but life-threatening condition that may require extracorporeal life support (ECLS). A systematic review was conducted to evaluate the outcomes of patients receiving ECLS..

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Mortality-related predictors in patients receiving extracorporeal membrane oxygenation after coronary artery bypass grafting: a retrospective study

Abstract Background This study aimed to evaluate in-hospital mortality and to identify predictors of mortality in coronary artery bypass grafting (CABG) patients receiving veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support. Methods..

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Long-term psychological outcomes after extracorporeal membrane oxygenation: A systematic review and meta-analysis

Abstract Background Use of extracorporeal membrane oxygenation (ECMO) for cardiorespiratory failure has increased substantially. While long-term outcomes for psychological health are increasingly assessed and addressed in critical care survivorship research,..

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Extracorporeal membrane oxygenation initiation timing and prognosis: a systematic review and meta-analysis

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a critical life-support intervention for patients with severe respiratory and circulatory failure. Nevertheless, identifying the optimal timing of ECMO initiation and its correlation..

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Extracorporeal Membrane Oxygenation Prior to Death: Standardized Terminology for ECMO-Supported Organ Donation Pathways

Abstract The expanding use of extracorporeal cardiopulmonary resuscitation (ECPR) has introduced new clinical scenarios at the intersection of extracorporeal life support and organ donation. Current donor classification systems do not..

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Timing of spontaneous breathing in veno-venous extracorporeal membrane oxygenation: An exploratory analysis of intensive care outcomes

Abstract Background The clinical impact of early spontaneous breathing during veno-venous extracorporeal membrane oxygenation (VV ECMO) for acute respiratory distress syndrome (ARDS) is unclear, balancing potential benefits (reducing sedation and..

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Cannula Selection and Flow Dynamics in ECMO

Abstract As ECMO continues to grow beyond the CVOR, a growing number of physicians outside cardiac surgery are being asked to cannulate. This expansion is an important step toward building..

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Renal replacement therapy in patients under extracorporeal membrane oxygenation: a narrative review

Abstract Background The use of extracorporeal membrane oxygenation (ECMO) has expanded for severe respiratory and circulatory failure. Acute kidney injury (AKI) is one of the most frequent complications. Up to..

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Hemoperfusion during extracorporeal membrane oxygenation: an updated systematic review and meta-analysis of 8,151 patients

Abstract Background This systematic review and meta-analysis evaluated the clinical efficacy and safety of hemoperfusion in adults receiving extracorporeal membrane oxygenation (ECMO). Methods We systematically searched PubMed, Embase, the Cochrane..

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Hemodynamic monitoring during ECMO

Abstract Extracorporeal membrane oxygenation (ECMO) is an established life-saving therapy for severe acute respiratory distress syndrome and cardiogenic shock, yet it profoundly alters cardiopulmonary physiology and challenges conventional hemodynamic monitoring...

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Scoping review of contemporary adult venoarterial extracorporeal membrane oxygenation (VA ECMO) selection criteria and decision-making mechanisms

Abstract Adult venoarterial extracorporeal membrane oxygenation (VA ECMO) is a costly life support therapy, where patient selection remains a significant hinge-point in determining patient outcomes. Despite this, few sites have..

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Toward standardized guidelines for distal perfusion cannulae in V-A ECMO and ECPELLA: timing, sizing, monitoring, and management

Abstract Acute limb ischemia (ALI) remains one of the most common complications of peripheral veno-arterial extracorporeal membrane oxygenation (V-A ECMO). Across heterogeneous cohorts, reported ALI rates vary widely (≈8–30% and..

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Side Port Resistance Limits Distal Perfusion Flow

Abstract Peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) and minimally invasive cardiac surgery often require femoral arterial cannulation, wherein lower limb ischemia remains a major complication. Although introducer sheaths with side..

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Modeling the Cost-Effectiveness of Incorporating Extracorporeal Cardiopulmonary Resuscitation Strategy in Out-of-Hospital Cardiac Arrest Patients

Abstract Objectives: To evaluate the cost-effectiveness of implementing an extracorporeal cardiopulmonary resuscitation (ECPR) strategy for refractory out-of-hospital cardiac arrest (OHCA) compared with current practice in Singapore, where it is not..

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Case-specific optimal extracorporeal membrane oxygenation configuration for cardiogenic shock in the peripartum period: a case report

Abstract For pregnant patients with severe coronavirus disease 2019 (COVID-19) requiring veno-venous (V-V) extracorporeal membrane oxygenation (ECMO), the ideal timing of delivery is uncertain, particularly when complicated by cardiogenic shock...

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Management of Extracorporeal Membrane Oxygenation for Cardiogenic Shock

Abstract Clinical Criteria and Assessment (Hypotension, Hypoperfusion, Rising Lactate, and Escalating Vasopressors) Profound hypotension, ongoing CS despite optimal medical treatment, escalating vasopressor requirements, rapidly deteriorating cardiac function, worsening lactic acidosis,..

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ROTEM versus conventional coagulation tests in evaluating coagulopathy and transfusion requirement in ECMO patients: A retrospective study

Abstract Introduction Critically ill ECMO patients face high bleeding risks from anticoagulation and other factors. Although viscoelastic tests, like ROTEM, are widely used to assess hemostasis, evidence for their superiority..

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Preoperative Transcranial Doppler Findings and Postoperative Delirium After Cardiac Surgery in Elderly Patients: A Prospective Observational Study

Abstract Postoperative delirium (POD) is a common neurocognitive complication after cardiac surgery in elderly patients and is associated with adverse clinical outcomes. Impaired cerebral autoregulation and reduced cerebrovascular reserve may..

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Venopulmonary Extracorporeal Membrane Oxygenation: Overview, Applications, and Current Evidence

Abstract Extracorporeal membrane oxygenation (ECMO) has become an essential supportive therapy for patients with severe respiratory and/or cardiac failure. While conventional configurations such as veno-venous and veno-arterial ECMO have well-established..

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Association between lactate to albumin ratio and 28-day all-cause mortality in patients with extracorporeal membrane oxygenation: a retrospective multi-cohort study

Abstract Background The relationship between lactate-to-albumin ratio (LAR) and mortality in patients with cardiogenic etiology undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) remains unclear. Against this backdrop, the present study is..

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Acute brain injury in adult post-cardiotomy cardiogenic shock patients receiving central vs. peripheral VA-ECMO: A single-center experience and systematic review…

Abstract Background Postcardiotomy cardiogenic shock (PCS) is a life-threatening complication after adult cardiac surgery that frequently necessitates venoarterial extracorporeal membrane oxygenation (VA-ECMO). Central and peripheral VA-ECMO cannulation strategies generate distinct..

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Left Ventricular Venting Strategies for Cardiogenic Shock in Patients Treated With Extracorporeal Cardiopulmonary Support V-A ECMO: From Left Ventricular Unloading…

Abstract While veno-arterial extracorporeal membrane oxygenation (V-A ECMO) has become central in the management of patients in advanced stages of cardiogenic shock due to its relative ease of deployment, there..

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The Utility of Extracorporeal Membrane Oxygenation in the Setting of Chronic Thromboembolic Pulmonary Hypertension

Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease that occurs due to fibrotic remodeling of the pulmonary vessels. This leads to increased pressure overload onto the right ventricle,..

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Optimizing Regional Access to Extracorporeal Cardiopulmonary Resuscitation: A Geographic-Information-System-Based Comparison of Hospital- and Prehospital-Initiated Strategies in Nara Prefecture, Japan

Abstract Background: Extracorporeal cardiopulmonary resuscitation (ECPR) can improve outcomes following refractory out-of-hospital cardiac arrest (OHCA); however, access is constrained by geography and resources. This study compared two strategies against the..

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Safety of prolonged anticoagulation-free venovenous ECMO management beyond 72 hours in post-traumatic ARDS: A single-center retrospective cohort study

Abstract Introduction Standard anticoagulation protocols for patients with trauma-related acute respiratory distress syndrome (TR-ARDS) undergoing venovenous extracorporeal membrane oxygenation (VV-ECMO) are often inapplicable due to high bleeding risks. This study..

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Safety of Invasive Procedures During Adult Extracorporeal Membrane Oxygenation: A Systematic Review

Abstract Background/Objectives: Adult patients supported with extracorporeal membrane oxygenation (ECMO) frequently require invasive diagnostic, therapeutic, surgical, or bedside procedures during ongoing extracorporeal support. These procedures are clinically challenging because ECMO-related anticoagulation,..

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Publication and Retraction Activity in the Field of Extracorporeal Membrane Oxygenation: Origins, Concerns, and Perspectives

Abstract Background Extracorporeal membrane oxygenation (ECMO) has become a vital life-support tool in critical care, particularly during the COVID-19 pandemic. The rapid growth of ECMO research necessitates bibliometric analysis to..

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Challenges of Intra-Aortic Balloon Pump and Extracorporeal Membrane Oxygenation in Cardiogenic Shock: Real-World Outcomes

Abstract Background: The aim of this study was to assess the long-term outcomes of patients treated with intra-aortic balloon pump (IABP) alone and in combination with extracorporeal membrane oxygenation (ECMO),..

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