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Vascular implications of non-pulsatile flow extracorporeal life support

Abstract Extracorporeal life support has become a widely integrated tool in treating refractor cardiopulmonary failure. Under normal physiologic conditions, arterial blood flow is inherently pulsatile, and cyclic shear stress plays..

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Long-term quality of life and functional outcomes in extracorporeal membrane oxygenation survivors

Abstract Extracorporeal membrane oxygenation (ECMO) has become an increasingly vital intervention for patients with severe cardiac and respiratory failure, significantly improving short-term survival rates. However, there is growing recognition of..

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ELSO-score: A practical pre-ECMO risk model for predicting in-hospital mortality in patients receiving VA-ECMO

Abstract Background Despite advancements in management strategies, patients with refractory cardiogenic shock (CS) have high mortality. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly utilized as temporary mechanical support in these..

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How to optimize brain perfusion and prevent cerebral complications during extracorporeal life support

Abstract Extracorporeal life support (ECLS) is increasingly used to rescue patients with refractory respiratory failure, cardiogenic shock and/or cardiac arrest. Acute brain injury during ECLS is common and associated with..

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Prophylactic temporary mechanical circulatory support: The new paradigm in cardiac surgery

Abstract Background Post-cardiotomy cardiogenic shock (PCCS) remains one of the most lethal complications of cardiac surgery, with high in-hospital mortality despite major improvements in operative techniques, and intensive care management...

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A Novel Trans-Septal Cannula for Wearable Extracorporeal Membrane Oxygenation: In Vitro Hemodynamic Evaluation and Placement Feasibility

Abstract Extracorporeal membrane oxygenation (ECMO) supports patients with end-stage heart and lung disease awaiting transplantation. In pulmonary hypertension, veno-arterial ECMO (VA-ECMO) is common but linked to vascular complications and limited..

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Hemodynamic monitoring during veno-venous extracorporeal membrane oxygenation: A scoping review

Abstract Background In adult patients receiving veno-venous Extracorporeal Membrane Oxygenation (VV ECMO), cardiovascular performance plays a critical role in determining oxygen delivery, organ perfusion and safe titration of extracorporeal support...

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ECMO transports perspectives on organization and patient management: A narrative review

Abstract Background Extracorporeal membrane oxygenation (ECMO) is an established life support technique for refractory acute cardiorespiratory failure in children and adult patients. However, ECMO support is provided only by specialized..

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Use of extracorporeal circulation in multidisciplinary approach and replantation strategies for traumatic limb amputations: A case report

Abstract Background Traumatic major limb amputations require urgent intervention to prevent irreversible tissue necrosis and life-threatening systemic complications due to warm ischemia. We aim to demonstrate the efficacy of extracorporeal..

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Extracorporeal life support in lung transplantation with dual-lumen cannulas: A systematic review

Abstract Background Refractory end-stage lung failure may benefit from extracorporeal life support (ECLS) as a bridge to lung transplantation. Venovenous (VV) extracorporeal membrane oxygenation (ECMO) is indicated in patients who..

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Changes in hemodynamics, cardiac energetics, and cell signaling pathways induced by veno-arterial extracorporeal membrane oxygenation with or without left ventricular…

Abstract Background Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a commonly used in refractory cardiogenic shock (CS) but may exacerbate left ventricular (LV) loading conditions and impair cardiac energetics. Adjunctive LV..

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Impact of eosinophil levels on postoperative clinical outcomes in patients undergoing extracorporeal circulation: a retrospective cohort study

Abstract Background Extracorporeal circulation (ECC) is an essential operation in many cardiac surgeries, but contact between blood and connecting tubes can activate inflammatory factors and adversely affect complement. Previous studies..

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Development of a Plasma Free Hemoglobin-Adsorbing Device for Extracorporeal Therapies

Abstract In extracorporeal therapies such as cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO), the transport of blood through artificial circulation frequently results in the rupture of erythrocytes, releasing hemoglobin..

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Preoperative Platelet Count Predicts In-Hospital Mortality in Patients Supported With Venoarterial Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study

Abstract Objectives To determine whether preoperative platelet (PLT) count independently predicts in-hospital mortality in patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO). Design Secondary analysis of a prospectively maintained institutional registry...

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Impact of combined ECMO - CRRT support on patient outcomes and risk factors: a multicenter retrospective study

Abstract Objective This study aimed to investigate the association of continuous renal replacement therapy (CRRT) use with the prognosis of patients undergoing extracorporeal membrane oxygenation (ECMO) and to explore its..

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Integrated or Parallel Configurations for Renal Replacement Therapy in Patients on VenoArterial Extracorporeal Membrane Oxygenation, a Single Center Retrospective Study

Abstract Background Acute kidney injury (AKI) is frequent in patients supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO), largely due to the severity of cardiogenic shock and multiorgan failure. Renal replacement..

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Epidemiology and outcomes of nosocomial infections in patients undergoing extracorporeal membrane oxygenation support: an eight-year retrospective cohort study

Abstract Background Patients supported with extracorporeal membrane oxygenation (ECMO) are susceptible to healthcare-associated infections (HAIs), which may worsen outcomes. However, epidemiological data from Latin American centres remain scarce. Methods We..

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Machine learning based retrospective cohort study to predict mortality risk in Chinese patients undergoing extracorporeal membrane oxygenation

Abstract Although extracorporeal membrane oxygenation (ECMO) has emerged as a pivotal temporary extracorporeal life support in critically ill patients, it is associated with a high risk of mortality. Establishing a..

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The Design of Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease Extracorporeal Membrane Oxygenation Study

Abstract Acute kidney injury (AKI) and fluid accumulation (FA) are common during extracorporeal membrane oxygenation (ECMO) support and are associated with increased morbidity and mortality. Despite their clinical importance, contemporary..

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Association between platelet indices and next-day bleeding and clotting in children and adults on extracorporeal membrane oxygenation: A retrospective study

Abstract Introduction Bleeding and clotting phenotypes are common in patients supported with Extracorporeal Membrane Oxygenation (ECMO) and are associated with increased mortality. However, tools to distinguish bleeding from clotting phenotypes..

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Cumulative exposure to factor XIII deficiency during veno-arterial extracorporeal membrane oxygenation: a prospective cohort study

Abstract Factor XIII (FXIII) contributes to clot stability and reduces clot susceptibility to lysis through fibrin cross-linking. Standard coagulation tests like prothrombin time and activated partial thromboplastin time do not..

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Decompensated Differential Carbon Dioxide Removal During Venoarterial Extracorporeal Membrane Oxygenation: A Physiologic Framework

Abstract Decompensated differential carbon dioxide (CO2) removal can occur during spontaneous breathing on peripheral venoarterial extracorporeal membrane oxygenation (V-A ECMO) when a low right radial arterial partial pressure of carbon..

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Enhancing early detection of acute brain injury using heart rate variability in patients on venoarterial extracorporeal membrane oxygenation

Abstract Introduction Early detection of acute brain injury (ABI) in patients on venoarterial extracorporeal membrane oxygenation (VA ECMO) is challenging. We aimed to investigate if heart rate variability (HRV) in..

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Improving bleeding and thrombosis in patients with extracorporeal life support: could hematology help?

Abstract Despite the advances in technology, new patient populations, new medications, and multiple monitoring algorithms for anticoagulation, bleeding, and thrombosis complications remain high among those receiving extracorporeal life support (ECLS)..

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Monitoring Hemostatic Function During Extracorporeal Membrane Oxygenation with Point-of-Care Viscoelastic Assays: A Narrative Review

Abstract Extracorporeal membrane oxygenation (ECMO) has increasingly been used in patients with refractory severe cardiorespiratory failure in recent years. The use of ECMO necessitates anticoagulation as blood passes through an..

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Percutaneous Versus Surgical Cannulation for Veno-Arterial Extracorporeal Life Support: A Systematic Review and Meta-Analysis

Abstract Background and Aims Extracorporeal life support (ECLS) is a critical intervention in the management of severe cardiac and respiratory failure. Among the commonly used cannulation techniques, percutaneous cannulation (PC)..

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Extracorporeal life support in adult critically ill patients: mechanisms of benefit in respiratory and cardiac failure

Abstract Extracorporeal life support provides temporary cardiorespiratory support for patients with severe, potentially reversible cardiac and/or respiratory failure refractory to conventional measures. Its application has broadened across a wide spectrum..

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The roles and responsibilities of an advanced practice nursing team for coordinating extracorporeal life support in intensive care: A qualitative…

Abstract Introduction Extracorporeal membrane oxygenation (ECMO) is a type of mechanical circulatory support that is increasingly utilised for severe cardiorespiratory failure in the intensive care unit (ICU) setting. ECMO is..

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Use of extracorporeal membrane oxygenation with a cardiotomy reservoir for patient blood management in thoracoabdominal open surgery: A single centre…

Abstract Open thoracoabdominal aortic aneurysm repair (TAAAR) is associated with mortality rates of between 8% and 25%. One of the characteristics of TAAAR is massive bleeding that requires multiple units..

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Sweep Flow Nitric Oxide Effects on Coagulation, Inflammation, and Endothelial System Activation During Extracorporeal Membrane Oxygenation

Abstract Extracorporeal membrane oxygenation (ECMO) can trigger a systemic inflammatory response syndrome (SIRS) with activation of inflammatory, endothelial, and coagulation system pathways. We assessed in a randomized trial whether a)..

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