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Perioperative blood management in Jehovah’s Witnesses

Abstract Background Jehova′s Witnesses refuse the administration of allogenic blood products for religious reasons. This stance represents a special challenge for the perioperative management and requires individualized ethically sensitive and..

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Impact of three-dimensional heart models on surgical planning and outcomes in congenital heart disease: a systematic review and meta-analysis

Abstract Background Congenital heart disease surgery includes intricate structures that are perhaps hard to completely understand by traditional two-dimensional shapes. Individualised, centre-based three-dimensional (3D) heart models may enhance structural imaging and..

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Early versus late surgical start times for on‐pump cardiac surgery

Abstract Rationale Circadian rhythms affect cardiovascular function, and the timing and severity of stroke and myocardial infarction (commonly known as a heart attack). Afternoon cardiac surgery may improve outcomes by..

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Early oxygenator failure during cardiopulmonary bypass with preserved neurological outcome: a case report

Abstract Background Oxygenator failure during cardiopulmonary bypass (CPB) is a rare but potentially catastrophic intraoperative event that can result in sudden hypoxemia and neurological injury if not promptly recognized and..

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Low cardiac index during periods of arterial hypotension and risk of acute kidney injury in cardiac surgery

Abstract Background Cardiac index (CI) and mean arterial pressure (MAP) are concurrent determinants of renal perfusion. Hypotension is associated with acute kidney injury (AKI), but clinical trials focused solely on..

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Establishing Cardiopulmonary Bypass Before General Anesthesia in a Patient Undergoing Right Atrial Myxoma Resection

Abstract We describe a case of establishing cardiopulmonary bypass (CPB) before general anesthesia in a person who has an obstructive right atrial myxoma protruding into the right ventricle (RV). A..

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A Retrospective Analysis of Thromboelastometry and Conventional Laboratory Values in Nonsurgical and Noncardiac Surgery Patients: Not What One Might Expect…

Abstract Background Thromboelastometry is often used to guide coagulation management, but validation outside cardiac surgery is limited. We evaluated correlations between thromboelastometry parameters and conventional laboratory tests in noncardiac patients..

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Effectiveness of sodium bicarbonate Ringer’s solution as a priming fluid for cardiopulmonary bypass: a propensity score matching study

Abstract Purpose This study aimed to evaluate the clinical effects of sodium bicarbonate Ringer’s solution(BRS) as a priming fluid for cardiopulmonary bypass (CPB). Methods A total of 159 patients undergoing..

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Combined Platelet and Red Blood Cell Salvage During Cardiac Surgery

Abstract Patient blood management (PBM) aims to improve patient outcome by managing and preserving a patient’s own blood and its components. Among the many recommended interventions, reducing intraoperative blood loss..

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The American Society of ExtraCorporeal Technology Standards and Guidelines for Pediatric and Congenital Perfusion Practice: 2025 Update

Abstract Background In 2019, the American Society of Extracorporeal Technology (AmSECT) approved the inaugural Standards and Guidelines for Pediatric and Congenital Perfusion Practice. These standards and guidelines were created with the..

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Thrombocytopenia After Cardiac Surgery: A Single-Center Retrospective Study

Abstract Background: Postoperative thrombocytopenia is a frequent complication in cardiac surgery, associated with increased morbidity and mortality. Our study aimed to describe platelet count after cardiac surgery and identify predictors..

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Plasma Biomarkers of Brain Injury in Critically Ill Children Receiving Extracorporeal Membrane Oxygenation

Abstract Importance  Timely identification of acute brain injury (ABI) in children receiving extracorporeal membrane oxygenation (ECMO) support is critical for early neuroprotective interventions. Objectives  To determine if elevations in plasma glial fibrillary..

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Influence of Human Factors on Coagulation Management in Cardiac Surgery: A Retrospective Analysis

Abstract Objectives To determine if the administration of coagulation products in cardiac surgery depends on the anesthesiologist’s exposure/number of cases per year, being on-call the same night as the surgery,..

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Perioperative Management and Surgical Approaches in a Rare Case of Coronary Artery Bypass Grafting Surgery in a Patient with Takayasu’s…

Introduction Takayasu’s arteritis (TA) is an idiopathic vasculitis that mainly affects the aorta and its proximal branches. The female-to-male ratio is 8:1. The mean age at the time of diagnosis..

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Use of andexanet alfa: A British Society for Haematology position statement

Abstract Andexanet alfa (Ondexxya) currently holds UK marketing authorisation (MA) for adult patients treated with a direct factor Xa (FXa) inhibitor (apixaban or rivaroxaban) when reversal of anticoagulation is indicated..

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AI-induced never-skilling in medical education

Abstract The integration of artificial intelligence (AI) into medical training is accelerating faster than the educational frameworks designed to govern it. This Perspective identifies a risk that has received insufficient..

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Intestinal microbiota dynamics in postoperative delirium following cardiac surgery with cardiopulmonary bypass: an observational study

Abstract Background Postoperative delirium (POD) is a common complication of cardiac surgery with cardiopulmonary bypass (CPB), and it is associated with systemic inflammation and gut–brain axis dysregulation. This study investigated..

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Comprehensive Coagulation Management in Cardiac Surgery: Anticoagulants, Heparin Resistance, Monitoring, and Bleeding Risks

Abstract Effective coagulation management is pivotal to optimizing outcomes in cardiac surgery, influencing bleeding risk, transfusion requirements, and overall perioperative safety. This comprehensive review examines current strategies, limitations, and emerging..

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FXII decline during cardiopulmonary bypass and the limits of routine coagulation assays: a prospective observational analysis

Abstract Background The contact activation system is triggered when blood comes into contact with artificial surfaces. Cardiopulmonary bypass (CPB) induces such activation, however the extent of factor XII (FXII) reduction..

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A Systematic Review of How Cardiopulmonary Bypass Parameters Influence Electroencephalogram Signals

Abstract Background: Cardiopulmonary bypass (CPB) is an essential technique for cardiac surgery but significantly increases the risk of perioperative neurological complications. Electroencephalography (EEG) enables real-time monitoring of brain function and..

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Impact of an Autotransfusion Device on Platelet Count and Transfusion Requirements in Cardiac Surgery: An Observational Study

Abstract Objectives To compare postoperative platelet counts in patients in whom intraoperative cell salvage (ICS) was performed using either a centrifugation-based device (ICS-centrifugation) or a filtration-based device (ICS-filtration; Same) for..

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Next generation spray-dried on-demand plasma: A multicenter, randomized, dose-escalation, first-in-human safety study

Abstract Background Prehospital plasma transfusion for patients at risk of hemorrhagic shock reduces mortality, but cold-chain and logistical constraints limit product availability. This study reports the first-in-human clinical evaluation of..

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Hypobaric type oxygenators during cardiopulmonary bypass for cardiac surgery to reduce gaseous microemboli: A randomized controlled trial

Abstract Objectives Neurological complications after cardiac surgery have been associated with gaseous microemboli generated during cardiopulmonary bypass. We undertook a trial to assess whether a novel dual-chamber oxygenator, designed to..

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60 years of ARDS and the evolution of extracorporeal lung support – from ECMO to ECCO2R

Abstract Extracorporeal life support (ECLS), including venovenous extracorporeal membrane oxygenation (VV-ECMO) and  extracorporeal carbon dioxide removal (ECCO₂R), is an established treatment for selected patients with acute respiratory distress syndrome (ARDS)...

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Low-Dose Postoperative Amino Acid Infusion and Kidney Protection After Cardiac Surgery: A Before-and-After Observational Cohort Study

Abstract Objectives To evaluate the real-world impact of implementing routine postoperative amino acid infusion on cardiac surgery–associated acute kidney injury (AKI). Design Before-and-after study. Setting Intensive care unit (ICU). Participants..

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Evaluating Four HIT Prediction Scores After Cardiac Surgery With Cardiopulmonary Bypass: A Comparative Study

Abstract Objectives To compare the diagnostic performance of 4 clinical prediction scores for heparin-induced thrombocytopenia (HIT) in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Design Bicentric retrospective observational study...

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Evaluation of nursing performance during coronary artery bypass grafting surgeries using machine learning analysis of surgical videos: a multicenter retrospective…

Abstract Background Coronary Artery Bypass Grafting (CABG) is a high-risk, complex cardiac procedure that relies heavily on effective nursing collaboration to ensure surgical safety and improve patient outcomes. The advancement..

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Postoperative Bleeding Definitions as the Foundation of Hemostasis in Pediatric Cardiac Surgery

Abstract Effective perioperative hemostasis in pediatric cardiac surgery depends not only on accurate diagnostics and targeted transfusion strategies but also on a clear and consistent definition of postoperative bleeding. Despite..

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Predictive value of cerebral oxygenation with near infrared spectroscopy for in-hospital mortality in pediatric congenital heart disease surgery: a retrospective…

Abstract Aim Congenital heart disease still has significant morbidity and mortality despite advances in surgery. Inadequate tissue perfusion is thought to be the primary cause. Monitoring children with cerebral oxygenation..

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Prehabilitation clinic in cardiac surgery: multidisciplinary protocol for the improvement of postoperative outcomes

Abstract Background Prehabilitation in cardiac surgery is a multidisciplinary approach aimed at optimizing the clinical and functional status of patients awaiting elective procedures. Interventions addressing nutrition, physical activity, psychological support..

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