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Extracorporeal Membrane Oxygenation Prior to Death: Standardized Terminology for ECMO-Supported Organ Donation Pathways

Abstract The expanding use of extracorporeal cardiopulmonary resuscitation (ECPR) has introduced new clinical scenarios at the intersection of extracorporeal life support and organ donation. Current donor classification systems do not..

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Simulation use in perfusion education: A 2025 survey of United States programs

Abstract Background: Simulation-based education (SBE) is increasingly used in training students in allied healthcare, yet data on its role in United States (U.S.) perfusion programs are limited. This study surveyed perfusion..

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Conceptions of human factors in simulation-based education: a phenomenographic study

Abstract Background Human factors (HF) are integral to patient safety. Simulation-based education (SBE) is widely used to teach HF, yet facilitators conceptualise HF in varied ways. This study explored facilitators’..

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Promoting Psychological Safety for All Participants During a High-Intensity Interprofessional Simulation Event

Abstract Simulation is an excellent educational methodology for healthcare learners to practice skills for medical scenarios that are low in frequency but high in emotional intensity. However, these educational experiences..

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Estimation of hemoglobin concentration at the initiation of cardiopulmonary bypass using support vector regression

Abstract Background: Hemodilution during cardiopulmonary bypass (CPB) is a standard perfusion strategy used to reduce blood viscosity and enhance microcirculatory flow. The hemodilution rate, expressed as hemoglobin (Hb) concentration, is..

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Development and Validation of an Integrated Artificial Intelligence-Powered Clinical Decision Support Application for Cardiac Critical Care: Combining Coagulation Management, Blood…

Abstract This study describes the development and preliminary validation of an integrated clinical decision support application (Cardiac Critical Care Advisor Pro, CCA Pro v6.0) that combines viscoelastic coagulation analysis, arterial..

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Evaluating the impact of implementing an ECPR protocol on prehospital resuscitation quality: a randomized controlled simulation study

Abstract Background Extracorporeal Cardiopulmonary Resuscitation (ECPR) is increasingly considered for prehospital cardiac arrest management; however, its impact on resuscitation performance remains unclear. This study aimed to determine whether integrating an..

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Pulses that predict: Postoperative perfusion index and outcomes in high-risk pediatric cardiac surgery

Abstract Background Children undergoing high-risk cardiac surgery face significant postoperative morbidity and mortality risk, and early recognition of impaired systemic perfusion is critical. Current monitoring modalities, such as lactate, central..

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Understanding pressure excursions in extracorporeal technologies: The role of shear stress and hematologic predisposition

Abstract Platelets play a pivotal role in hemostasis, where their activation is tightly regulated by biochemical agonists such as thrombin, collagen, and adenosine diphosphate, all of which signal through calcium-mediated..

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Timing of spontaneous breathing in veno-venous extracorporeal membrane oxygenation: An exploratory analysis of intensive care outcomes

Abstract Background The clinical impact of early spontaneous breathing during veno-venous extracorporeal membrane oxygenation (VV ECMO) for acute respiratory distress syndrome (ARDS) is unclear, balancing potential benefits (reducing sedation and..

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Proteomic, Transcriptomic, and Metabolic Mediators of Post-Cardiopulmonary Bypass Vasoplegia Syndrome

Abstract Objective Post-cardiopulmonary bypass (post-CPB) vasoplegia syndrome (VS) is associated with a dysregulated inflammatory response and a higher morbidity and mortality, but the molecular pathways involved have been incompletely identified...

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Central and Mixed Venous Oxygen Saturation in Cardiac Surgery: A Systematic Review and Meta-analysis

Abstract Central venous oxygen saturation (ScvO2) and mixed venous oxygen saturation (SvO2) are widely used markers of tissue perfusion. Their role in cardiac surgery remains uncertain. This study conducted a..

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Coagulation-Friendly Environment in Cardiac Surgery: A Narrative Review

Abstract Perioperative bleeding remains a major complication in cardiac surgery and is associated with increased morbidity, mortality, and transfusion requirements. While patient blood management strategies and goal-directed hemostatic therapies have..

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Cannula Selection and Flow Dynamics in ECMO

Abstract As ECMO continues to grow beyond the CVOR, a growing number of physicians outside cardiac surgery are being asked to cannulate. This expansion is an important step toward building..

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Renal replacement therapy in patients under extracorporeal membrane oxygenation: a narrative review

Abstract Background The use of extracorporeal membrane oxygenation (ECMO) has expanded for severe respiratory and circulatory failure. Acute kidney injury (AKI) is one of the most frequent complications. Up to..

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Determinants of postoperative recovery after cardiac surgery in older adults: A multidimensional cross-sectional study

Abstract Background Postoperative recovery in older adults undergoing cardiac surgery is a complex and multidimensional process associated with clinical, psychological, and nutritional factors; however, these factors are often addressed separately..

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Hemoperfusion during extracorporeal membrane oxygenation: an updated systematic review and meta-analysis of 8,151 patients

Abstract Background This systematic review and meta-analysis evaluated the clinical efficacy and safety of hemoperfusion in adults receiving extracorporeal membrane oxygenation (ECMO). Methods We systematically searched PubMed, Embase, the Cochrane..

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Effect of the Duration of Cardiopulmonary Bypass on Oxygenation Predicted by Measuring Thoracic Fluid Content Using Electrical Cardiometry in Infants…

Abstract Objective To evaluate the relationship between cardiopulmonary bypass (CPB) duration, change in thoracic fluid content (ΔTFC) measured using electrical cardiometry, and postoperative oxygenation in infants undergoing ventricular septal defect..

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A Slow Retreat

Abstract Imagine, for a moment, that targeted temperature management (TTM), the standard of care in post cardiac arrest management for more than two decades, was built on a false premise..

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Advanced organ protection strategies in aortic arch surgery: A narrative review

Abstract Objective Aortic arch surgery remains a complex procedure associated with significant morbidity and mortality. This review aims to provide insights into the current concepts and evidence regarding organ protection..

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Cerebral Autoregulation During Antegrade Cerebral Perfusion in Neonates Undergoing Congenital Cardiac Surgery

Abstract Objectives Antegrade cerebral perfusion (ACP) is used to protect the brain during aortic arch reconstructions. It is unknown whether cerebral autoregulation remains intact during ACP. This study was designed..

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Contemporary extracorporeal cardiopulmonary resuscitation programs for cardiac arrest

Abstract Cardiac arrest is a leading cause of global mortality, with low survival rates despite advances in resuscitation science. Reported survival ranges from 8% to 34% for out-of-hospital and in-hospital..

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A heart-on-a-chip simultaneously monitoring contractility and troponin secretion under dynamic mechanical stimulation

Abstract Mechanical stimulation can remodel the physiological mechanical microenvironment of cardiomyocytes and influence their maturation and injury progression. However, the dynamic process by which cardiomyocytes transition from adaptive maturation to..

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Filtered or Fried? Rethinking Intraoperative Cell Salvage in Liver Transplantation

Abstract Over the past 2 decades, liver transplantation (LT) has undergone a profound transformation in different fields. In particular, once characterized by massive blood product utilization, LT is now characterized..

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Integration of the Korean and World Databases for Pediatric and Congenital Heart Surgery: A Model for Global Registry Collaboration

Abstract Background: Establishing the Korean Pediatric and Congenital Heart Surgery Database (KPCHSD) and linking it to the World Database for Pediatric and Congenital Heart Surgery (WDPCHS) is an important step..

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A Comprehensive Total Body Perfusion Strategy vs Conventional Techniques in Elective Aortic Arch Surgery: A Comparative Analysis

Abstract Objectives Aortic arch surgery traditionally relies on hypothermic circulatory and cardioplegic arrest, exposing myocardium and visceral organs to ischaemia-reperfusion injury. We developed a total body perfusion (TBP) strategy providing..

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Prostaglandin Administration and Outcomes in Children on Extracorporeal Membrane Oxygenation

Abstract Objectives Extracorporeal Membrane Oxygenation (ECMO) is associated with high risks of bleeding and clotting. While traditional anticoagulants like heparin and bivalirudin target the coagulation cascade, prostaglandins including PGE1 and PGI2 may..

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Postoperative C-Reactive Protein Resolution Patterns in Patients With and Without Postoperative Atrial Fibrillation After Cardiac Surgery

Abstract Objectives Postoperative atrial fibrillation is common after cardiac surgery. Effective preventative measures are lacking, partly due to an incomplete understanding of its pathogenesis. Inflammation is a major contributor to..

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An Insight Into a Potential Antithrombin-Independent Mechanism of Inadequate Heparin Response in Neonates and Infants Undergoing Pediatric Cardiac Surgery: An…

Abstract Objectives Inadequate heparin response is frequently observed in neonates and young infants. While low antithrombin level is considered to be the primary cause, the existing literature suggests that it..

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Comparative decision-making analysis of extracorporeal membrane oxygenation candidacy based on a survey of pediatric critical care fellow and attending physicians

Abstract Background: Extracorporeal membrane oxygenation (ECMO) candidacy decisions for children with respiratory failure can be variable among pediatric critical care attending physicians, and prior studies showed that baseline functional status..

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