Tags Archives: nitric oxide

Perfusfind S.L.

Abstract Background Nitric oxide (NO) is reported to play several protective roles in the inflammatory response and ischemia/reperfusion injury. This study evaluated the effect of nitric oxide (NO) on postoperative..

Perfusfind S.L.

Abstract Excessive right heart load imposes an acute or chronic injury on the right ventricle (RV), predisposing critically ill neonates and cardiac surgical patients to RV failure, low cardiac output..

Perfusfind S.L.

Abstract Objectives:  To test the feasibility and safety of a randomized controlled trial (RCT) delivering nitric oxide into the sweep gas of extracorporeal membrane oxygenation (ECMO) circuits (sNO) in critically..

Perfusfind S.L.

Abstract ‘Liquid-like’ solid surfaces that overcome the limitations of lubricant-infused slippery surfaces, have garnered attention as passive antibiofouling coatings for biomedical applications. However, lack of intrinsic bioactivity limits its ability to..

Perfusfind S.L.

Abstract Sweep gas nitric oxide (sNO) is emerging as an adjunctive therapy, which may have positive impacts on thrombosis and inflammation during ECMO treatment. sNO is administered to the gas..

Perfusfind S.L.

Abstract Thrombosis and inflammation represent major challenges limiting the functionality of asymmetric poly(4-methyl-1-pentene) (PMP) hollow fiber membranes in extracorporeal membrane oxygenation (ECMO) systems. Moreover, the interplay between these two pathological..

Perfusfind S.L.

Abstract Postoperative organ dysfunction remains a major challenge in adult cardiac surgery with cardiopulmonary bypass (CPB), frequently involving the kidneys, heart, and lungs. These complications are primarily driven by hemolysis,..

Perfusfind S.L.

Abstract Solutions to reduce the need for systemic anticoagulation during extracorporeal life support would improve safety and utility. The study objective was to evaluate the safety and efficacy of a..

Perfusfind S.L.

Abstract Background: Inhalational anesthetic agents are a major source of potent greenhouse gases in the medical sector, and reducing their emissions is a readily addressable goal. Nitrous oxide (N2O) has..

Perfusfind S.L.

Abstract Background:  Postoperative Acute kidney injury (AKI) is a significant concern for cardiac surgery patients with chronic kidney disease (CKD). Effective pharmacological interventions to mitigate these risks are urgently needed...

Perfusfind S.L.

Abstract Objective This study aimed to assess the safety and potential efficacy of high-dose inhaled nitric oxide therapy for the prevention of postoperative pneumonia in cardiac surgery patients Methods A..

Perfusfind S.L.

Abstract Importance  Children with congenital heart defects who undergo cardiopulmonary bypass (CPB) surgery are at risk for delayed or impaired neurodevelopmental outcomes. Nitric oxide (NO) added to the CPB oxygenator may..

Perfusfind S.L.

Abstract This study presents the utilization of a novel, highly lipophilic nitric oxide (NO) donor molecule, S-nitroso-1-adamantanethiol (SNAT), for developing an NO-emitting polymer surface aimed at preventing thrombus formation and bacterial..

Perfusfind S.L.

Abstract Nitric oxide (NO) was proclaimed the 1992 “molecule of the year” by Culotta in Science magazine because of its importance in neuroscience, physiology and immunology. Inhaled NO has been..

Perfusfind S.L.

Abstract The effect of nitric oxide (NO) supplied to the sweep gas of the oxygenator on the formation of gaseous microemboli during cardiopulmonary bypass has been studied in animal experiments..

Perfusfind S.L.

Abstract Nitric oxide (NO), a selective pulmonary vasodilator, can be delivered via conventional ICU and anesthesia machine ventilators. Anesthesia machines are designed for rebreathing of circulating gases, reducing volatile anesthetic..

Perfusfind S.L.

Abstract BACKGROUND  Cardiac surgery involving cardiopulmonary bypass induces a significant systemic inflammatory response, contributing to various postoperative complications, including pulmonary dysfunction, myocardial and kidney injuries. OBJECTIVE  To investigate the effect..

Perfusfind S.L.

Abstract Objective The impact of nitric oxide (NO) administered via cardiopulmonary bypass (CPB) on pediatric heart surgery remains controversial. The objective of this study is to conduct a comprehensive systematic..

Perfusfind S.L.

Abstract This study aims to determine the effectiveness of administering 80 ppm nitric oxide in reducing kidney injury, mitochondrial dysfunction and regulated cell death in kidneys during experimental perfusion. Twenty-four..

Perfusfind S.L.

Abstract Cardiac surgeries under cardiopulmonary bypass (CPB) are complex procedures with high incidence of complications, morbidity and mortality. The inhaled nitric oxide (iNO) has been frequently used as an important..

Perfusfind S.L.

Abstract Background: Nitric Oxide (NO) is a naturally occurring modulator of inflammation found in the human body. Several studies in the pediatric cardiothoracic surgery literature have demonstrated some beneficial clinical effects..

Perfusfind S.L.

Abstract Nitric oxide (NO) can be safely delivered through the sweep gas to the oxygenator of an extracorporeal membrane oxygenation (ECMO) circuit. It has theoretical benefits such as preventing platelet..

Perfusfind S.L.

Abstract Background: The  during  (CPB) to improve Recovery in Infants with  (NITRIC) trial, a 1320-patient, multicentre, , is aiming to improve survival free of ventilation after CPB by using nitric oxide delivered into the  of the..

Perfusfind S.L.

Abstract Background Nitric oxide (NO) is a gas naturally produced by the human body that plays an important physiological role. Specifically, it binds guanylyl cyclase to induce smooth muscle relaxation...

Perfusfind S.L.

Abstract Introduction The objective of this study was to investigate the potential synergistic utility of a combination of gaseous nitric oxide (gNO)-intravenous Cangrelor as an effective pharmacological option for the..

Perfusfind S.L.

Abstract Objective. To evaluate the effect of NO added to the sweep gas of the oxygenator during cardiopulmonary bypass (CPB) on the liver and kidneys in pigs.  Methods. An experiment..

Perfusfind S.L.

Abstract Background Children with end-stage lung disease are commonly managed with extracorporeal life support (ECLS) as a bridge to lung transplantation. A pumpless artificial lung (MLung) is a portable alternative..

Perfusfind S.L.

Abstract Purpose Investigate inhaled nitric oxide’s influence on mortality rates, mechanical ventilation and cardiopulmonary bypass duration, and length of stay in the intensive care unit and hospital when administered during..

Perfusfind S.L.

Abstract Background and aims:  Cardiopulmonary bypass (CPB) utilized for cardiac surgeries has been associated with significant mortality and adverse outcomes. The benefits of incorporating nitric oxide (NO) into the CPB..

Perfusfind S.L.

Abstract Background Extracorporeal life support (ECLS) has extensive applications in managing patients with acute cardiac and pulmonary failure. Two primary modalities of ECLS, cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation..