Abstract Traditional methods of heart transplantation utilizing allografts from donors after circulatory death (DCD) involve 2 periods of ischemia and 2 ischemia reperfusion injuries (IRI). Both ischemia and IRI are..
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Abstract Intestinal ischemia/reperfusion (I/R) injury is a critical clinical syndrome precipitated by the restoration of blood flow following intestinal ischemia, a common occurrence in perioperative settings such as abdominal aortic..
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Abstract Extracorporeal membrane oxygenation (ECMO) and endovascular balloon occlusion of the aorta (REBOA) have been reported to manage hemodynamics and reduce blood loss and transfusion requirements during high-risk abdominal surgeries...
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Abstract Background Blood oxygen content and management during cardiopulmonary bypass (CPB), particularly during reperfusion phase after cross-clamping related ischemia, may influence systemic oxygen utilization, oxidative stress, and organ ischemia/reperfusion injury...
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Introduction Cardiopulmonary bypass (CPB) is a life-saving technology used in cardiac surgery; however, it triggers a systemic inflammatory response (SIRS) due to blood contact with non-endothelial surfaces, ischemia-reperfusion injury, and..
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Abstract Chen et al. used a rat model of cardiopulmonary bypass followed by 30-min ischemia (induced by ascending aorta blockage) and 15-min reperfusion []. They reported that pyruvate dehydrogenase E1α..
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Abstract Introduction Critically ill patients supported with venoarterial (VA ECMO) are at risk of developing severe arterial , which has been associated with increased mortality. Lower saturation targets in this population may..
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Abstract Although surgical techniques and perioperative care have made significant advances, perioperative mortality in cardiac surgery remains relatively high. Single- or multiple-organ failure remains the leading cause of postoperative mortality...
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Abstract In the United States, about one million people are seen to visit the operating theater for cardiac surgery annually. However, nearly half of these visits result in complications such..
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Abstract Cardiac reperfusion injury is a well-established outcome following treatment of acute myocardial infarction and other types of ischemic heart conditions. Numerous cardioprotection protocols and therapies have been pursued with..
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Cyclosporine A-enhanced cardioplegia preserves mitochondrial basal respiration after ischemic arrest
Abstract Background: Mitochondrial permeability transition pore (mPTP) opening plays a crucial role in cell death during ischemia-reperfusion injury (IRI). Cyclosporine A (CsA) inhibits mPTP opening. This study aimed to investigate..
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Abstract The protective effects of preprocedural esmolol on myocardial injury and hemodynamics have not, to date, been investigated in patients who were scheduled for cardiac surgeries under a cardiopulmonary bypass..
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Abstract Objective induces in the small . One reason for this damage is a perfusion shift from the muscular toward the mucosal layer. This study investigated the effect of this perfusion shift..
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Abstract Objectives The aim of this pilot study was to elucidate the effects of exogenous (NO) supply to the circuit for cardioprotection against during (CABG) with (CPB). Methods A total of 60 patients with scheduled for..
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