Abstract Background: Prone positioning improves survival in patients with acute respiratory distress syndrome (ARDS) by reducing ventilator-induced lung injury and enhancing ventilation–perfusion matching. Whether these physiological benefits translate to patients..
Read MoreAbstract Background Separation from venovenous extracorporeal membrane oxygenation (VV-ECMO) is a pivotal transition for patients with acute respiratory distress syndrome (ARDS). Impaired alveolar ventilation more so than oxygenation may be..
Read MoreAbstract OBJECTIVES: To evaluate the relationship between the duration of pre-extracorporeal membrane oxygenation (ECMO) mechanical ventilation and mortality in acute respiratory distress syndrome (ARDS) patients undergoing venovenous ECMO. DESIGN: Retrospective..
Read MoreAbstract Background Neurological complications significantly contributed to mortality in patients with acute respiratory distress syndrome (ARDS) supported by venovenous extracorporeal membrane oxygenation (VV ECMO). Early fluctuations in arterial partial pressure..
Read MoreAbstract Vilobelimab, a first-in-class, human–mouse chimeric immunoglobulin G4 (IgG4) kappa monoclonal antibody, targets human complement component 5a (C5a) in plasma. Unlike upstream complement inhibitors, vilobelimab does not inhibit the generation..
Read MoreAbstract Decisions regarding veno-venous extracorporeal membrane oxygenation (vv-ECMO) in patients with acute respiratory distress syndrome (ARDS) are often based solely on clinical and physiological parameters, which may insufficiently reflect severity..
Read MoreAbstract To investigate the feasibility of regional oxygen saturation (rSO2) monitoring for preventing acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) caused by cardiopulmonary bypass (CPB) in infants undergoing ventricular..
Read MoreAbstract Purpose To assess whether prone positioning (PP) increases bleeding risk compared to supine positioning in ARDS patients undergoing veno venous Extracorporeal Membrane Oxygenation (VV ECMO). Materials and Methods A..
Read MoreAbstract Purpose The optimal ventilation strategy in acute respiratory distress syndrome (ARDS) patients with veno-venous extracorporeal membrane oxygenation (VV-ECMO) remains unknown. We aimed to compare the effects of two ultra-protective..
Read MoreAbstract Extracorporeal Life Support (ECLS), including venovenous (VV) extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide removal (ECCO2R) is a temporary support option for patients with severe respiratory failure. Current..
Read MoreAbstract Introduction: In life-threatening conditions like severe acute respiratory distress syndrome (ARDS), rescue interventions like extracorporeal membrane oxygenation (ECMO) should be initiated urgently to resolve an otherwise potentially adverse clinical outcome...
Read MoreAbstract Whether an anticoagulation strategy combining bivalirudin and aspirin during extracorporeal membrane oxygenation (ECMO) would prolong oxygenator use is unknown. No clear data exist on oxygenator life span during prolonged..
Read MoreAbstract Background Hemolysis is a common complication in critically ill patients with sepsis, acute respiratory distress syndrome (ARDS) or therapy with extracorporeal membrane oxygenation (ECMO). Heme degradation product bilirubin might..
Read MoreAbstract Background Casualties of military conflicts suffer a multitude of injuries, and recent research has documented a significant number develop acute respiratory distress syndrome (ARDS). The present study undertakes a..
Read MoreAbstract Introduction Extracorporeal membranous oxygenation (ECMO) as a salvage therapy for patients with severe acute respiratory distress syndrome (ARDS) has been described but experience is limited in burn cases. Few..
Read MoreAbstract Purpose: The selection and intensity of respiratory support for ARDS are guided by PaO 2/FiO2 . However, ventilator-induced lung injury (VILI) is linked to respiratory mechanics and ventilator settings...
Read MoreAbstract While writing this editorial, we learned that Professor Luciano Gattinoni—a giant in our field—had passed away. “Giant” seems an inadequate descriptor for a physician-scientist whose profound insights have fundamentally..
Read MoreAbstract Background Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a supportive therapy for acute respiratory failure with increased risk of packed red blood cells (PRBC) transfusion. Blood cell salvage (BCS) aims..
Read MoreAbstract Introduction This study aimed to identify characteristics associated with survival during and post Extra Corporeal Membrane Oxygenation (ECMO) therapy, in patients with acute respiratory distress syndrome (ARDS) during the..
Read MoreAbstract Background: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is a critical intervention for patients with severe lung failure, especially acute respiratory distress syndrome (ARDS). The weaning process from ECMO relies largely..
Read MoreAbstract Introduction Extracorporeal membrane oxygenation (ECMO) is a vital intervention for acute respiratory distress syndrome (ARDS), yet its efficacy with coronavirus disease 2019 (COVID-19) remains unknown. This study compared the..
Read MoreAbstract Purpose: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is an integral part of the management algorithm of patients with severe respiratory failure refractory to evidence-based conventional treatments. Right ventricular injury (RVI)..
Read MoreAbstract Building solid evidence in intensive care medicine is challenging, mostly due to patient heterogeneity and concomitant treatment interactions. In the context of acute respiratory distress syndrome (ARDS), only two..
Read MoreIntroduction Managing acute respiratory distress syndrome (ARDS) poses significant challenges due to its heterogeneous nature. As of 2024, the updated global definition of ARDS now includes patients receiving noninvasive ventilation..
Read MoreAbstract Purpose The development of acute kidney injury (AKI) after the acute respiratory distress syndrome (ARDS) reduces the chance of organ recovery and survival. The purpose of this study was..
Read MoreAbstract In the initial phases of veno-venous extracorporeal membrane oxygenation (VV ECMO) support for severe acute respiratory distress syndrome (ARDS), ultraprotective controlled mechanical ventilation (CMV) is typically employed to limit..
Read MoreAbstract Acute respiratory distress syndrome (ARDS) comprises 10–30% of critical care admissions worldwide []. ARDS outcomes have improved secondary to ventilatory strategies that may potentially mitigate ventilator-induced lung injury []...
Read MoreAbstract Background: Acute respiratory distress syndrome (ARDS) presents a significant challenge in critical care settings, characterized by compromised gas exchange, necessitating in the most severe cases interventions such as veno-venous extracorporeal..
Read MoreAbstract Target values for arterial carbon dioxide tension (PaCO2) in extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS) are unknown. We hypothesized that lower PaCO2 values on ECMO would..
Read MoreAbstract In critically ill patients with moderate to severe acute respiratory distress syndrome (ARDS) receiving invasive mechanical ventilation, prone positioning for 16 hours/day has been shown to confer significant mortality..
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