Summary Acute kidney injury (AKI) is a common complication of sepsis and significantly increases patient morbidity and mortality. Nearly two-thirds of patients with septic shock develop AKI, resulting in a six- to eightfold increase in mortality. Despite progress in understanding its pathophysiology and biomarkers, there are still limited effective therapies. This review outlines the epidemiology, […]
Sepsis-Associated Acute Kidney Injury Read Post »
Abstract Background Phospholipid transfer protein (PLTP), a glycoprotein widely expressed in the body, is primarily involved in plasma lipoprotein metabolism. Previous research has demonstrated that PLTP can exert anti-inflammatory effects and improve individual survival in patients with sepsis and endotoxemia by neutralizing LPS and facilitating LPS clearance. However, the role of PLTP in sepsis-associated acute
The role of phospholipid transfer protein in sepsis-associated acute kidney injury Read Post »
Abstract This narrative review delves into the intricate interplay between the lungs and the kidneys, with a focus on elucidating the pathogenesis of diseases influenced by immunological factors, acid–base regulation, and blood gas disturbances, as well as assessing the effects of various therapeutic modalities on these interactions. Key disorders, such as anti-glomerular basement membrane (anti-GBM)
Advancements in understanding the mechanisms of lung–kidney crosstalk Read Post »
Abstract Medications are a common cause of AKI, especially for patients admitted to hospital wards and the intensive care unit. Although drug-related kidney injury occurs through different mechanisms, this review will focus on three specific types of tubulointerstitial injury. Direct acute tubular injury develops from several medications, which are toxic to various cellular functions. Their
Drug-Induced Acute Kidney Injury Read Post »