Abstract Objectives To evaluate the effect of autologous platelet-rich plasma (aPRP) on perioperative allogeneic blood product transfusion requirement in patients undergoing cyanotic congenital heart disease (CCHD) surgery and patients’ prognosis...
Read MoreAbstract Objective Premature infants with congenital heart disease (CHD) face high perioperative mortality and neurological risk. We evaluated whether cardiopulmonary bypass timing independently influences mortality or neurologic injury in premature..
Read MoreAbstract Background Intraoperative cell salvage is widely used in pediatric scoliosis surgery to reduce allogeneic transfusion requirements. However, its clinical effectiveness and economic impact remain uncertain. The objective of this..
Read MoreAbstract Introduction Aortic arch repair following the Norwood operation remains challenging because of dense adhesions and the risk of phrenic or recurrent nerve injury. We present a novel approach employing..
Read MoreAbstract Background Antegrade cerebral perfusion (ACP) is widely used during congenital aortic arch reconstruction; however, variability persists regarding cannulation strategies. Direct innominate artery cannulation may simplify arterial access while maintaining..
Read MoreAbstract Background While minimally invasive techniques for simple septal defects have demonstrated comparable safety and efficacy to median sternotomy, clinical outcomes following minimally invasive repair of Tetralogy of Fallot (TOF)..
Read MoreAbstract Background The incidence and risk factors of cardiac surgery–associated acute kidney injury (CS-AKI) are variable. We describe the incidence of severe postoperative CS-AKI (i.e., stage 2 or 3 AKI)..
Read MoreAbstract Objective: To evaluate inflammatory biomarkers and lipidomic profiles in tracheal aspirates (TA) of infants with congenital heart disease (CHD), by pulmonary blood flow (Qp) high/low grouping at the time..
Read MoreAbstract Introduction del Nido cardioplegia had not been commercially available in the United Kingdom prior to the DESTINY trial, a multi-centre individually randomised controlled trial to evaluate whether del Nido..
Read MoreAbstract Background: Allogenic blood product transfusion has well-documented risks and adverse outcomes. To limit perioperative transfusions for neonates and infants undergoing cardiac surgery, our institution launched a blood conservation program..
Read MoreAbstract Introduction Cardiopulmonary bypass (CPB) provokes a systemic inflammatory response with important consequences for infants and children undergoing repair of congenital heart disease [, , ]. Inflammation engages overlapping coagulation..
Read MoreAbstract The gut microbiome has emerged as an important regulator of cardiovascular physiology through interconnected metabolic, immune, inflammatory, and endocrine pathways. Although the gut–heart axis has been extensively investigated in..
Read MoreAbstract Background: Pediatric cardiac surgery requiring cardiopulmonary bypass (CPB) is associated with high transfusion rates. While transfusions increase risks of adverse events, existing evidence cannot differentiate whether risks arise from..
Read MoreAbstract Objectives: To describe the rate, characteristics, and outcomes of pediatric extracorporeal cardiopulmonary resuscitation (ECPR) for in-hospital cardiac arrest (IHCA) in Japan and evaluate temporal trends. Design: Retrospective cohort using..
Read MoreAbstract The application of cardiopulmonary bypass (CPB) has significantly advanced cardiovascular surgery. However, CPB-associated brain injury remains a critical complication that affects patient prognosis and quality of life. Overt stroke..
Read MoreAbstract Introduction Tetralogy of Fallot (TOF) is the most common cyanotic heart disease (CHD). The associated cardiac abnormalities disrupt oxygenation and depending on disease severity, infants with TOF syndrome are..
Read MoreAbstract Background: Multisystem inflammatory syndrome in children (MIS-C) is a relatively rare complication of COVID-19, with frequent cardiovascular involvement, in terms of pericarditis, valvulitis, coronary aneurysms, and myocardial dysfunction/cardiogenic shock...
Read MoreAbstract An 11-month-old infant was admitted to the intensive care unit after cardiorespiratory arrest associated with the parainfluenza virus. Despite interventions, deterioration persisted. Echocardiography revealed severe pulmonary hypertension, tricuspid gradient..
Read MoreAbstract Purpose Methylprednisolone is used during paediatric cardiac surgery with cardiopulmonary bypass to attenuate the systemic inflammatory response. However, developmental differences in drug disposition and cardiopulmonary bypass–related factors contribute to..
Read MoreAbstract Neonatal cardiac surgery requires cardiopulmonary bypass (CPB) strategies that minimize hemodilution while maintaining adequate oxygen delivery and hemostatic balance. Despite increasing emphasis on patient blood management (PBM), contemporary CPB..
Read MoreAbstract Background Cardiopulmonary bypass is associated with systemic inflammation during pediatric cardiac surgery and features elevated systemic concentrations of complement, cytokines and chemokines. The objective of this study is to..
Read MoreAbstract Background Brain development is altered in neonates with congenital heart disease (CHD), with well-characterised reductions in regional brain volumes and enlargement of CSF spaces. However, perioperative morphological changes remain..
Read MoreAbstract Objectives The hemostatic system in neonates and infants with congenital heart disease is distinct as a result of developmental and disease-specific factors, necessitating population-specific periprocedural evaluation and antithrombotic management...
Read MoreAbstract Purpose To evaluate changes in post-operative transfusion requirements of infants undergoing congenital diaphragmatic hernia (CDH) repair on ECMO following implementation of a perioperative guideline. Methods In 2021, a multidisciplinary..
Read MoreAbstract Objectives Cardiopulmonary bypass is necessary for surgical repair of complex congenital heart disease. We studied whether whole blood use in circuit prime and for initial intraoperative transfusion needs improved..
Read MoreAbstract Background: Among infants undergoing cardiac surgery, AKI may affect as many as 40% of this population and carries an unfavorable prognosis. A range of contributors has been implicated, including early..
Read MoreAbstract BACKGROUND We sought to determine if modified ultrafiltration (MUF) in the current era was associated with improved outcomes after neonatal cardiopulmonary bypass (CPB). METHODS Retrospective analysis of the PC4/NEPHRON..
Read MoreAbstract Lactate clearance is a key marker of oxygen delivery after neonatal cardiac surgery. While higher hematocrit (HCT) is often targeted to optimize oxygen delivery, its relationship with postoperative lactate..
Read MoreDr.Sam Zeraatian Nejad Davani, Cardiovascular and Thoracic Surgeon Transplant and Thoracic Organs Recovery Surgeon. Director of Georgia Atlanta Procure on Demand Thoracic Organs Transplant and Procurement Surgery. ..
Read MoreAbstract Introduction Congenital Heart Disease (CHD) remains a major health challenge globally, with surgical interventions being the primary treatment modality for many defects. While advancements in cardiac surgery have improved..
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