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Modeling the Cost-Effectiveness of Incorporating Extracorporeal Cardiopulmonary Resuscitation Strategy in Out-of-Hospital Cardiac Arrest Patients

Abstract Objectives: To evaluate the cost-effectiveness of implementing an extracorporeal cardiopulmonary resuscitation (ECPR) strategy for refractory out-of-hospital cardiac arrest (OHCA) compared with current practice in Singapore, where it is not..

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Case-specific optimal extracorporeal membrane oxygenation configuration for cardiogenic shock in the peripartum period: a case report

Abstract For pregnant patients with severe coronavirus disease 2019 (COVID-19) requiring veno-venous (V-V) extracorporeal membrane oxygenation (ECMO), the ideal timing of delivery is uncertain, particularly when complicated by cardiogenic shock...

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Management of Extracorporeal Membrane Oxygenation for Cardiogenic Shock

Abstract Clinical Criteria and Assessment (Hypotension, Hypoperfusion, Rising Lactate, and Escalating Vasopressors) Profound hypotension, ongoing CS despite optimal medical treatment, escalating vasopressor requirements, rapidly deteriorating cardiac function, worsening lactic acidosis,..

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ROTEM versus conventional coagulation tests in evaluating coagulopathy and transfusion requirement in ECMO patients: A retrospective study

Abstract Introduction Critically ill ECMO patients face high bleeding risks from anticoagulation and other factors. Although viscoelastic tests, like ROTEM, are widely used to assess hemostasis, evidence for their superiority..

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Preoperative Transcranial Doppler Findings and Postoperative Delirium After Cardiac Surgery in Elderly Patients: A Prospective Observational Study

Abstract Postoperative delirium (POD) is a common neurocognitive complication after cardiac surgery in elderly patients and is associated with adverse clinical outcomes. Impaired cerebral autoregulation and reduced cerebrovascular reserve may..

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Venopulmonary Extracorporeal Membrane Oxygenation: Overview, Applications, and Current Evidence

Abstract Extracorporeal membrane oxygenation (ECMO) has become an essential supportive therapy for patients with severe respiratory and/or cardiac failure. While conventional configurations such as veno-venous and veno-arterial ECMO have well-established..

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Association between lactate to albumin ratio and 28-day all-cause mortality in patients with extracorporeal membrane oxygenation: a retrospective multi-cohort study

Abstract Background The relationship between lactate-to-albumin ratio (LAR) and mortality in patients with cardiogenic etiology undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) remains unclear. Against this backdrop, the present study is..

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Acute brain injury in adult post-cardiotomy cardiogenic shock patients receiving central vs. peripheral VA-ECMO: A single-center experience and systematic review…

Abstract Background Postcardiotomy cardiogenic shock (PCS) is a life-threatening complication after adult cardiac surgery that frequently necessitates venoarterial extracorporeal membrane oxygenation (VA-ECMO). Central and peripheral VA-ECMO cannulation strategies generate distinct..

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Left Ventricular Venting Strategies for Cardiogenic Shock in Patients Treated With Extracorporeal Cardiopulmonary Support V-A ECMO: From Left Ventricular Unloading…

Abstract While veno-arterial extracorporeal membrane oxygenation (V-A ECMO) has become central in the management of patients in advanced stages of cardiogenic shock due to its relative ease of deployment, there..

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The Utility of Extracorporeal Membrane Oxygenation in the Setting of Chronic Thromboembolic Pulmonary Hypertension

Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease that occurs due to fibrotic remodeling of the pulmonary vessels. This leads to increased pressure overload onto the right ventricle,..

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Optimizing Regional Access to Extracorporeal Cardiopulmonary Resuscitation: A Geographic-Information-System-Based Comparison of Hospital- and Prehospital-Initiated Strategies in Nara Prefecture, Japan

Abstract Background: Extracorporeal cardiopulmonary resuscitation (ECPR) can improve outcomes following refractory out-of-hospital cardiac arrest (OHCA); however, access is constrained by geography and resources. This study compared two strategies against the..

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Safety of prolonged anticoagulation-free venovenous ECMO management beyond 72 hours in post-traumatic ARDS: A single-center retrospective cohort study

Abstract Introduction Standard anticoagulation protocols for patients with trauma-related acute respiratory distress syndrome (TR-ARDS) undergoing venovenous extracorporeal membrane oxygenation (VV-ECMO) are often inapplicable due to high bleeding risks. This study..

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Safety of Invasive Procedures During Adult Extracorporeal Membrane Oxygenation: A Systematic Review

Abstract Background/Objectives: Adult patients supported with extracorporeal membrane oxygenation (ECMO) frequently require invasive diagnostic, therapeutic, surgical, or bedside procedures during ongoing extracorporeal support. These procedures are clinically challenging because ECMO-related anticoagulation,..

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Publication and Retraction Activity in the Field of Extracorporeal Membrane Oxygenation: Origins, Concerns, and Perspectives

Abstract Background Extracorporeal membrane oxygenation (ECMO) has become a vital life-support tool in critical care, particularly during the COVID-19 pandemic. The rapid growth of ECMO research necessitates bibliometric analysis to..

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Challenges of Intra-Aortic Balloon Pump and Extracorporeal Membrane Oxygenation in Cardiogenic Shock: Real-World Outcomes

Abstract Background: The aim of this study was to assess the long-term outcomes of patients treated with intra-aortic balloon pump (IABP) alone and in combination with extracorporeal membrane oxygenation (ECMO),..

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Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial

Abstract Background In patients receiving extracorporeal membrane oxygenation (ECMO), standard practice is full-dose intravenous unfractionated heparin (UFH) targeting an activated partial thromboplastin time of 2·0–2·5 times baseline to reduce thrombotic..

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ECMO for patients with obesity: evidence and practice

Abstract Purpose Obesity is increasingly encountered among patients requiring extracorporeal membrane oxygenation (ECMO) for severe respiratory or cardiac failure. It alters respiratory and cardiovascular physiology and drug pharmacokinetics and introduces..

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Hemodynamic-guided V-A ECMO management for cardiogenic shock: Insight from initial experience from TWEET study (to wean an ECMO trials)

Abstract Background Veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is used for refractory cardiogenic shock, yet optimal weaning strategies and the role of left ventricular (LV) venting remain unclear. The TWEET-1..

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Nutrition provision across acute hospitalization in adult patients receiving extracorporeal membrane oxygenation: A prospective multicenter observational, registry-embedded study

Abstract Background Patients receiving extracorporeal membrane oxygenation (ECMO) are considered nutritionally vulnerable, with previous studies focussed on Intensive Care Unit (ICU) admission alone. We aimed to address this gap by..

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Mechanical Ventilation and Extracorporeal Membrane Oxygenation in Acute Respiratory Insufficiency

Abstract Background: Invasive ventilation saves lives but carries major risks, including ventilation-associated lung damage and long-term functional impairment. Data from recent studies compel reassessment of the evidence for every step of..

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Nitric Oxide–Releasing Surfaces Reduce Thrombosis in Venovenous Extracorporeal Life Support: A 5 day Long Ovine Study

Abstract Extracorporeal life support (ECLS) components designed to reduce clot formation have been developed, but thrombosis remains a significant challenge, requiring systemic anticoagulation. To address this, we evaluated a nitric..

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A novel flow-controlled transaortic catheter venting (TACV) strategy for LV decompression in VA-ECMO: A case report

Abstract Background Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides crucial circulatory and respiratory support in refractory cardiogenic shock and cardiac arrest. However, peripheral VA-ECMO increases left ventricular (LV) afterload through retrograde..

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Feeding under support in critical care illness: metabolic and nutritional management during extracorporeal membrane oxygenation and continuous renal replacement therapy

Abstract Purpose of review The use of life-support therapies like extracorporeal membrane oxygenation (ECMO), mechanical circulatory systems (MCS), and continuous renal replacement therapy (CRRT) creates a complex and dynamic metabolic..

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60 years of ARDS and the evolution of extracorporeal lung support – from ECMO to ECCO2R

Abstract Extracorporeal life support (ECLS), including venovenous extracorporeal membrane oxygenation (VV-ECMO) and  extracorporeal carbon dioxide removal (ECCO₂R), is an established treatment for selected patients with acute respiratory distress syndrome (ARDS)...

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Prehabilitation clinic in cardiac surgery: multidisciplinary protocol for the improvement of postoperative outcomes

Abstract Background Prehabilitation in cardiac surgery is a multidisciplinary approach aimed at optimizing the clinical and functional status of patients awaiting elective procedures. Interventions addressing nutrition, physical activity, psychological support..

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Neurological complications in veno-arterial extracorporeal membrane oxygenation and the potential role of targeted temperature management– A narrative review

Abstract Background Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly used to provide circulatory support in acute cardiac failure. However, it is frequently complicated by neurological injury, which substantially worsens morbidity..

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Microcirculation and Cerebrovascular Autoregulation in Patients With Mechanical Circulatory Support Devices

Abstract Acute brain injury (ABI) affects up to one-third of patients using mechanical circulatory support (MCS). In venoarterial extracorporeal membrane oxygenation (VA ECMO), ABI incidence (11%-40%) has not improved in..

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Determination of brain death in potential donors on ECMO support

Abstract Background A recent update of the German directive on determining brain death introduced changes regarding the diagnostics in potential donors on extracorporeal membrane oxygenation (ECMO). Physicians familiar with ECMO must..

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Reliable Flow, Cost-Effective, Comfortable: Tunneled Veno-Pulmonary Artery Extracorporeal Membrane Oxygenation Cannulation Technique

Abstract Veno-venous (VV) extracorporeal membrane oxygenation (ECMO) has many limitations, including patient comfort and, oftentimes, mobility issues. Veno-pulmonary (VP) ECMO offers respiratory support without recirculation and right heart support. For..

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Venovenous Extracorporeal Membrane Support in the Setting of Type A Aortic Dissection Repair—Too Little Too Late?

Abstract Background Use of venoarterial (VA) extracorporeal membrane oxygenation (ECMO) in the setting of type A aortic dissection (TAAD) has been described in the literature as salvage therapy, with morbid..

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