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Managing Serum Lactate During Cardiopulmonary Bypass.

Serum lactate is a critical biomarker in cardiac surgery, offering insights into tissue oxygenation and metabolic status. Elevated lactate levels during cardiopulmonary bypass (CPB) can indicate inadequate perfusion, hypoxia, or..

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The effect of surgical field suction flow rate and venous reservoir levels on gaseous microemboli transmission

Abstract Background: Minimizing Gaseous microemboli (GME) introduced into the CPB circuit can help alleviate neurologic injury. This study focuses on understanding how suction flow rate and the reservoir level can..

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Is continuous in-line blood gas monitoring reliable during cardiopulmonary bypass when PaO2 and PaCO2 are calculated rather than measured?

Abstract Background: The accuracy and precision of continuous in-line blood gas monitoring (CILBGM) are crucial for optimal blood gas management during cardiopulmonary bypass (CPB) and improved patient outcomes. CILBGM devices,..

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Evaluating the Impact of a Standardized Protocol for Managing Refractory Vasoplegia After Cardiopulmonary Bypass

Abstract Objectives This study aimed to evaluate the hemodynamic impact and cost-effectiveness of a standardized protocol for refractory vasoplegia occurring after cardiopulmonary bypass (CPB). Design Observational, pre-post study. Setting A..

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Delta perfusion rate predicts the development of adverse outcome in cardiopulmonary bypass patients

Abstract Introduction: Despite the advances in CPB, various complications may occur. Prediction and anticipation of these undesirable outcomes is of great importance. For this reason, various markers have been tried to..

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Myocardial Protection with Cardioplegia in Cardiac Surgery: Optimizing Where We Are Now and Setting Goals for Where We Could Go…

Abstract The administration of cardioplegia is a core component of the multimodal approach to myocardial protection during cardiac surgery with cardiopulmonary bypass., An ideal cardioplegia solution should facilitate rapid cardiac arrest,..

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The effect of cardiopulmonary bypass prime solution volume on blood transfusion: how do perfusionists manage fluid and what is the…

Abstract Introduction: During cardiopulmonary bypass (CPB), adequate prime solution allows pre-treatment of the tubing line, oxygenator and blood pump, evacuation of air from the arterial conduit, and appropriate blood dilution. However,..

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A Prospective Observational Study on Role of Intraoperative Renal A Prospective Observational Study on Role of Intraoperative Renal & Muscle…

Abstract Objective Near Infra-Red Spectroscopy (NIRS), can be used to monitor renal tissue oxygenation (SrO2), as well as thenar muscle oxygenation (SmO2). In this study, we have examined the ability of..

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The effect of cardiopulmonary bypass on platelet distribution width, red cell distribution width – standard deviation, and platelet large cell…

Abstract Introduction: In patients undergoing cardiopulmonary bypass-guided cardiac surgery, knowledge of the preoperative effects of platelet distribution width (PDW), red cell distribution width - standard deviation (RDW-SD), and platelet large cell..

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A comparative study of the effect of slow and rapid initiation of cardiopulmonary pump on tissue oxygenation index and ischemic…

Abstract Introduction: Although the use of the heart-lung machine (HLM) is routine in cardiac operating theaters, there is still a lack of evidence-based guidelines concerning the optimal speed to reach..

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Initiating Cardiopulmonary Bypass Using a Dry Venous Line: Implications and Analysis

Abstract Cardiopulmonary bypass (CPB) is an essential component of modern cardiac surgery, allowing surgeons to temporarily replace heart and lung function during complex procedures. One important technical aspect of CPB..

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Post-operative oxygen delivery and delirium after cardiac surgery with cardiopulmonary bypass: A multisite retrospective cohort study of 1,690 patients

Abstract Introduction Delirium is a common, distressing, and dangerous complication after cardiac surgery with cardiopulmonary bypass (CPB) with few modifiable risk factors. This study aims to determine the association between..

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Benefits of nitric oxide administration during cardiopulmonary bypass on postoperative outcomes in adult patients: a meta-analysis and systematic review

Abstract Background Nitric oxide (NO) is reported to play several protective roles in the inflammatory response and ischemia/reperfusion injury. This study evaluated the effect of nitric oxide (NO) on postoperative..

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Endothelin-1 and Vasomotor Tone Following Cardioplegic Ischemia/Reperfusion and Cardiopulmonary Bypass

Abstract Endothelin-1 is a potent regulator of vasomotor tone and promotes endothelium-dependent vasoconstriction of vascular smooth muscle. Dysregulated vasomotor tone is a hallmark of microvascular pathology following cardiac surgery involving..

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Utilization of Cardiopulmonary Bypass in Trauma Patients: A Multi-Institutional Study of the American Association for the Surgery of Trauma

Abstract Background The purpose of this descriptive study was to characterize the utilization and outcomes of CPB after trauma. Methods This is an AAST-sponsored retrospective (2011-2021) multicenter (32 centers) study..

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The Impact of Cardiopulmonary Bypass on the Structure and Mechanics of Red Blood Cells: Pilot Study

Abstract Background/Objectives: Cardiopulmonary bypass (CPB) facilitates complex cardiac surgery but can damage erythrocyte membranes, impairing microcirculation and oxygen transport. Standard rheological tests assess overall blood properties but fail to define..

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Comparison of Classical Blood Cardioplegia and Modified Del Nido Cardioplegia on Postoperative Serum Lactate Levels and Extubation Times

Abstract Objective: To compare the effects of intermittent classical blood cardioplegia and single-dose modified Del Nido cardioplegia on postoperative serum lactate levels and extubation time in patients undergoing coronary artery bypass..

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Circulatory arrest time above 30 min have significantly detrimental effects on the outcomes of type a aortic dissection repair

Abstract Background Acute aortic dissection of the ascending aorta is a life-threatening disease that poses a significant challenge for cardiovascular surgeons. Dissection of the aorta typically occurs when the aortic..

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Association Between Intraoperative Hyperlactatemia and Infection After Cardiac Surgery With Cardiopulmonary Bypass: A Multicenter Retrospective Study

Abstract Objectives To test the hypotheses that intraoperative hyperlactatemia is independently associated with increased postoperative infection risk in cardiac surgery with cardiopulmonary bypass (CPB). Methods This study involved 4970 cardiac..

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Efficacy of Hemoadsorption in Cardiac Surgery with Cardiopulmonary Bypass: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abstract Objectives To evaluate the efficacy of intraoperative hemoadsorption (HA) during cardiopulmonary bypass (CPB) in reducing acute kidney injury (AKI) and other major postoperative complications in patients undergoing cardiac surgery...

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Engineering Development of a Bi-directional Arterial Cannula with Peripheral Access for Cardiopulmonary Bypass

Abstract Purpose Cardiopulmonary bypass (CPB) is a well-established procedure that uses cannulae during cardiac surgery to drain and return blood. In challenging cases (e.g. aortic dissection, reoperation), peripheral cannulation in..

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Undetected intracardiac thrombus and subsequent embolism following cardiopulmonary bypass: a case report

Abstract Background Heparin is commonly administered to prevent thrombosis during cardiopulmonary bypass (CPB). However, the development of intracardiac thrombi under CPB has still been reported. Case summary A 79-year-old man..

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Suspected Malignant Hyperthermia in a Patient Undergoing Cardiac Surgery: Perioperative Challenges and Management

Abstract Malignant hyperthermia (MH) is a rare but potentially fatal disorder characterized by a hypermetabolic state produced by exposure to triggering agents such as volatile anesthetics and succinylcholine., MH crises have..

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Effects of cardiopulmonary bypass on in vitro proliferation of human pancreatic cancer cells and plasma growth factor levels

Abstract Background Advances in medicine lead to an increase in the number of patients with concurrent heart disease and cancer. We investigated the effect of cardiac surgery under cardiopulmonary bypass..

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Is Cooler Safer and More Advantageous? A Feasibility Study in Rabbits

Abstract Objectives This study hypothesizes that induced hypothermia (IH) can safely extend aortic cross-clamp (ACC) time, significantly reducing metabolic burden and end-organ injury, thereby enabling more comprehensive aortic arch reconstructions..

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The history of cardiopulmonary bypass and the evolution of pneuma in cardiopulmonary medicine

Abstract Cardiopulmonary bypass (CPB) is one of the most groundbreaking medical innovations in history, enabling safe and effective heart surgery by temporarily replacing the function of the heart and lungs...

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Polymeric micro and nanoparticle release from cardiopulmonary bypass and extracorporeal membrane oxygenation circuits

Abstract Objectives Cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) or life support (ECLS) circuits are built from polymers and might release polymeric micro- and nanoparticles (MNP) into the circulation...

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Can a low prime volume arterial filter be used as an alternative for a venous bubble trap in minimal extracorporeal…

Abstract Background During cardiac surgery the use of a minimal extracorporeal circulation (MiECC) system may reduce the adverse effects for the patient. This is probably caused by reduced inflammation and..

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Comparison of 6% hydroxyethyl starch 130/0.4 vs 5% albumin in cardiopulmonary bypass for cardiac surgery

Abstract BACKGROUND The choice of priming and volume replacement fluids during cardiopulmonary bypass (CPB) in cardiac surgery impacts hemodynamic stability, coagulation, renal function, and patient outcomes. Hydroxyethyl starch (HES) 130/0.4..

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Central Aortic Cannulation as a Primary Strategy in Acute Type A Aortic Dissection Surgery

Abstract Objectives The central cannulation technique was introduced at our institution in 2018 and has evolved into a primary cannulation strategy for acute type A aortic dissection (ATAAD) surgery. This..

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