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Renal vein congestion aggravates renal injury associated with cardiopulmonary bypass

Abstract Background Elevated central venous pressure during cardiac surgery can lead to increased renal venous pressure, subsequently resulting in renal insufficiency. However, there is a lack of animal models available..

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Inhaled Milrinone in Weaning from Cardiopulmonary Bypass: A Case Study

Abstract Separation from cardiopulmonary bypass (CPB) is a critical phase of cardiac surgery, particularly in patients with pulmonary hypertension and right heart failure. Milrinone, a phosphodiesterase inhibitor, is often used..

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Vacuum-assisted venous drainage versus gravitational venous drainage in patients undergoing cardiac surgery: A meta-analysis

Abstract Introduction Vacuum-assisted venous drainage (VAVD) has been proposed as a better alternative option than conventional gravitational venous drainage (GVD) in cardiac surgery. However, the literature reports conflicting results between..

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Elevated oxygen extraction during heart transplantation is associated with increased morbidity and mortality: Implications for goal-directed perfusion

Abstract Background Goal-directed perfusion (GDP) during cardiopulmonary bypass (CPB) commonly targets indexed oxygen delivery (DO2i), yet fixed delivery thresholds may ignore patient-specific metabolic demand. The oxygen extraction ratio (O2ER) integrates..

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Association of Low Oxygen Delivery on Cardiopulmonary Bypass and Increased Long-Term Mortality

Abstract Background Although delivering less oxygen is associated with acute kidney injury, little is known about its association with long-term mortality and how the association may be modified by transfusion...

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Chest Wound Gunshot Management Aided by Cardiopulmonary Bypass: Interdisciplinary Teamwork or “Serendipity”?

Abstract Background and clinical significance. Penetrating cardiothoracic wounds require prompt treatment in order to decrease mortality and morbidity. Surgical therapy, aimed at bleeding control and removal of damaged tissue, varies widely..

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Is bedside empiricism the genuine gold standard of daily clinical practice? Rethinking evidence in extracorporeal care and perfusion

Abstract In extracorporeal life support and perfusion, progress has rarely followed the neat, linear hierarchy of evidence promoted by traditional evidence-based medicine. The randomized controlled trial (RCT) remains the proclaimed..

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Blood Prime Of The Cardiopulmonary Bypass Circuit In Congenital Heart Surgery

Abstract Introduction: The use of cardiopulmonary bypass (CPB) is necessary during the repair of most congenital heart disease (CHD). The surface area of the CPB circuit and the volume of..

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Comparing fluid dynamics of newborn and adult centrifugal pumps in cardiopulmonary bypass procedures

Abstract Background Cardiopulmonary bypass (CPB) plays a crucial role in cardiac surgery, with the pump being a key component affecting both hemolysis and thrombosis. Centrifugal levitating pumps (CP) have demonstrated..

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Hydrogel nanocomposite-based breathable non-adhesive coating for oxygen sensing film used within extracorporeal perfusion system

Abstract Real-time, quantitative biosensing within extracorporeal perfusion (ECP) and extracorporeal membrane oxygenation (ECMO) systems is key to advancing this life-support technology beyond the hospital setting to emergency care. Measuring and..

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Effects of noradrenaline, vasopressin, phenylephrine or metaraminol on kidney and brain microcirculation in ovine cardiopulmonary bypass: a randomised trial

Abstract Introduction Intra-operative hypotension is common during cardiopulmonary bypass and may contribute to tissue hypoxia. Tissue hypoxia has been linked to the development of postoperative kidney and brain injury. Vasopressors..

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Patient-Specific Susceptibility to the Nadir Oxygen Delivery on Cardiopulmonary Bypass

Abstract Objectives Maintaining a nadir oxygen delivery ≥ 280 mL/min/m2 during cardiopulmonary bypass is a pillar of the goal-directed perfusion strategy in cardiac surgery. However, there are patients who develop a..

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Factors affecting patient outcomes in pulmonary artery thromboendarterectomy under deep hypothermic circulatory arrest and cardiopulmonary bypass support----a single center’s experience

Abstract Objective To explore the factors affecting patient outcomes in pulmonary artery thromboendarterectomy (PTE) under deep hypothermic circulatory arrest (DHCA) and cardiopulmonary bypass (CPB) support and to provide a reference..

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Simultaneous coronary artery bypass grafting and transcarotid transcatheter aortic valve implantation using a cardiopulmonary bypass-assisted carotid perfusion

Abstract Managing severe  (AS) alongside complex  (CAD) in frail patients is challenging. A 79-year-old female with resting dyspnea was diagnosed with severe AS and CAD. While  (CABG) was the appropriate treatment for CAD,..

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The impact of pulsatile vs. non-pulsatile perfusion in patients undergoing cardiopulmonary bypass: A comprehensive systematic review and meta-analysis of 33…

Abstract Background Pulsatile perfusion is a developing technique that attempts to mimic the natural pulsatile flow of blood during cardiopulmonary bypass (CBP). Purpose This systematic review and meta-analysis was conducted..

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Evaluation of Knowledge, Attitudes, and Experiences of Perfusionists on the Safety of Cardiopulmonary Perfusion

Abstract Introduction Perfusion accidents still threaten the safety of perfusion during open-heart surgery. To prevent these accidents and increase perfusion safety, it is important to first determine the profile of..

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Propofol-supplemented cardioplegia: A multicenter blinded 3-group randomized trial (Propofol for Myocardial Protection Trial 2: ProMPT2)

Abstract Objective: Coronary artery bypass grafting using cardiopulmonary bypass and cardioplegic arrest is an effective treatment for coronary artery disease. Research suggests supplementing the cardioplegia solution with propofol may be..

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Cardiopulmonary bypass–mediated lung ischemia–reperfusion injury: A protective role of sitaxentan

Abstract Background Cardiopulmonary bypass is widely used in cardiac surgery but often leads to lung ischemia–reperfusion injury, a major cause of morbidity and mortality. Despite advances in critical care, effective..

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Cerebral Hemodynamic Changes and Postoperative Brain Function in Patients Undergoing Cardiac Valve Surgery With Cardiopulmonary Bypass: A Prospective Cohort Study

Abstract Background Cardiopulmonary bypass (CPB) during cardiac surgery disrupts cerebral hemodynamics, potentially leading to postoperative neurological complications such as delirium. Transcranial Doppler (TCD) offers non-invasive monitoring of cerebral blood flow..

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Comparison of post-operative inflammatory biomarkers between minimal invasive extracorporeal circulation and conventional extracorporeal circulation in cardiac surgery. A meta-analysis of…

Abstract Background/Aim Recent literature suggested that the use of Minimal Invasive Extracorporeal Circulation (MIECC) may mitigate the inflammatory response in patients undergoing cardiac surgery. We aimed to perform a meta-analysis..

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Impact of changes in cardiopulmonary bypass circuit design on pressure loss, wall shear stress, and venous drainage flow

Abstract Introduction Blood damage during cardiopulmonary bypass can trigger postoperative inflammatory responses and organ injury. Therefore, optimizing the blood circuit design to minimize damage remains essential. However, variations in venous..

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Between Air and Artery: A History of Cardiopulmonary Bypass and the Rise of Modern Cardiac Surgery

Abstract Cardiopulmonary bypass (CPB) is one of the most groundbreaking medical innovations in history, enabling safe and effective heart surgery by temporarily replacing the function of the heart and lungs...

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Inadequate Oxygen Delivery During Cardiopulmonary Bypass Drives Inflammatory Reaction after Cardiac Surgery

Abstract Objectives Systemic inflammatory response syndrome (SIRS) is a common complication following cardiopulmonary bypass (CPB), associated with increased mortality. We assessed the relationship between indexed oxygen delivery (DO2i) during CPB..

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Impact of Low Hematocrit on On-Pump Coronary Artery Bypass Graft Surgery Outcomes

Abstract Background: Low hematocrit level is a hematological problem that is frequently encountered during cardiopulmonary bypass (CPB) in patients undergoing on-pump coronary artery bypass grafting (CABG). This study aimed to..

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Monitoring Oxygen Delivery During Cardiopulmonary Bypass: A Preliminary Multinational Practice Survey

Abstract Objectives Oxygen delivery (DO2) is a pivotal factor in maintaining adequate tissue protection during cardiopulmonary bypass (CPB). Despite its clinical significance, there is currently no global consensus regarding standardized..

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Effect of Ciprofol on Postoperative Cognitive Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial

Abstract Purpose: To investigate the effects of ciprofol on postoperative cognitive function in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Patients and Methods: A total of 138 patients who underwent cardiac..

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Inadequate Oxygen Delivery During Cardiopulmonary Bypass Drives Inflammatory Reaction after Cardiac Surgery

Abstract Objectives Systemic inflammatory response syndrome (SIRS) is a common complication following cardiopulmonary bypass (CPB), associated with increased mortality. We assessed the relationship between indexed oxygen delivery (DO2i) during CPB..

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Delivery of oxygen during cardiopulmonary bypass and associated clinical outcomes among adult cardiac surgery patients: A systematic review

Abstract Purpose Oxygen delivery (DO2) during cardiopulmonary bypass (CPB) is critical in preventing postoperative complications in adult cardiac surgery. This systematic review aimed to assess the relationship between intraoperative DO2 during..

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Management of Emergency Cardiopulmonary Bypass Failure During Robot-Assisted Mitral Valve Repair: Successful Recovery With Hypothermia and Centrifugal Pump Exchange

Abstract CARDIOPULMONARY BYPASS (CPB) is an essential component of cardiac surgery, and its unexpected failure during surgery can compromise circulatory and respiratory management, potentially endangering the patient's life. In the..

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The effect of administration of Del Nido cardioplegia solution containing vitamin C on myocardial protection and clinical outcomes in patients…

Abstract Background A main concern during cardiac surgery is the protection of the heart. Myocardial ischemia tends to increase the generation of reactive oxygen species. Based on its oxidation–reduction potentials,..

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