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Indexed oxygen delivery and acute kidney injury during cardiopulmonary bypass: Threshold instability and cumulative oxygen debt

Abstract Rationale Acute kidney injury (AKI) is a common complication after adult cardiac surgery, affecting approximately 1 in 5 patients and conferring higher mortality, longer hospitalization, and increased resource use...

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A new beating heart model of cardiopulmonary bypass-induced acute kidney injury demonstrates heme protein toxicity and ferroptosis

Abstract Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in 20-30% of patients after heart surgery with cardiopulmonary bypass (CPB). AKI rates are even higher in VA ECMO treated patients...

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Renal oxygenation, function and histopathology in an ovine model of heart failure undergoing cardiopulmonary bypass with 48 hours of recovery: a…

Abstract Introduction Acute kidney injury is common after cardiac surgery requiring cardiopulmonary bypass, yet preventive strategies are limited. Progress has been hindered by a lack of clinically relevant experimental models..

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Interpreting the Acute Kidney Injury Signal With Intraoperative Hemoadsorption During Cardiopulmonary Bypass: Methodological Considerations

Abstract I read with interest the systematic review and meta-analysis by Samaniego-Laguna et al., which addresses whether intraoperative hemoadsorption during cardiopulmonary bypass (CPB) reduces postoperative complications. The reported reduction in..

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Update on Perioperative Prevention of Cardiac Surgery-Associated Acute Kidney Injury

Abstract Cardiac surgery-associated acute kidney injury (CS-AKI) increases short- and long-term mortality, progression to chronic kidney disease (CKD), and healthcare costs. Its pathogenesis is multifactorial—combining renal hypoperfusion, impaired oxygen delivery,..

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The incidence and risk factors associated with severe acute kidney injury and operative mortality in neonates following cardiac surgery: a…

Abstract Background The incidence and risk factors of cardiac surgery–associated acute kidney injury (CS-AKI) are variable. We describe the incidence of severe postoperative CS-AKI (i.e., stage 2 or 3 AKI)..

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Feasibility Study of Renal Negative Pressure Treatment After Cardiac Surgery With Cardiopulmonary Bypass

Abstract Background We conducted a technical feasibility and safety study of intraureteric renal negative pressure treatment (rNPT) in patients with chronic kidney disease undergoing elective cardiac surgery with cardiopulmonary bypass..

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Tandem ECMO/CRRT medical nutrition therapy clinical practice points: A literature review and Delphi consensus on clinical practice

Abstract Background Patients who undergo tandem extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapy (CRRT) have a high risk of metabolic disturbances, malnutrition, and fluid imbalances. ECMO/CRRT tandem therapy..

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Impact of Acute Kidney Injury on Hospitalization Outcomes in Patients with Chronic Kidney Disease Undergoing Cardiac Procedures with Cardiopulmonary Bypass…

Abstract Background Acute kidney injury (AKI) is a common complication after cardiac surgery and is associated with more infections, prolonged recovery, longer hospital stays, increased readmission rates, greater costs, and..

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Elevated Cardiopulmonary Bypass Flow for Renal Protection in Cardiac Surgery: A Randomized Trial

Abstract BACKGROUND: Acute kidney injury (AKI) is a common and severe complication after cardiac surgery with cardiopulmonary bypass (CPB). Experimental data suggest that increasing CPB flow beyond standard targets may..

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Mean arterial blood pressure during the first 24 hours after cardiac surgery and acute kidney injury: an observational cohort study

Abstract Objective(s): Mean arterial pressure (MAP) after cardiac surgery may contribute to acute kidney injury (AKI). We sought to identify threshold MAP values during the first 24 hours (h) postoperatively..

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Influence of microaxial flow pump level on haemolysis and kidney injury in patients with cardiogenic shock: a retrospective study

Abstract Aims Acute kidney injury (AKI) is common in patients treated with microaxial flow pumps (mAFP). Plasma-free haemoglobin (PFHb) due to haemolysis is known to increase kidney injury in a..

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Acute Kidney Injury After Cardiac Surgery in Low‑ and Middle‑Income Countries

Abstract Background: Cardiac‑surgery‑associated acute kidney injury (CSA‑AKI) is a frequent postoperative complication worldwide and is associated with increased mortality, prolonged intensive care unit stay, and substantial resource utilization. While reported..

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Haematocrit During Cardiopulmonary Bypass and Risk for Acute Kidney Injury: An Observational Single-Centre Study

Abstract Objectives Low haematocrit during cardiopulmonary bypass is a known risk factor for acute kidney injury, but it is unclear whether high haematocrit also increases acute kidney injury risk. We..

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Nadir Oxygen Delivery During Pediatric Cardiopulmonary Bypass and Postoperative Acute Kidney Injury: A Pilot Cohort Study

Abstract Background: Among infants undergoing cardiac surgery, AKI may affect as many as 40% of this population and carries an unfavorable prognosis. A range of contributors has been implicated, including early..

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Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery

Abstract Importance  Two percent to 50% of patients undergoing elective cardiac surgery experience acute kidney injury (AKI) postoperatively. Medications to prevent AKI after elective cardiac surgery have not been identified. Objective  In..

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Perioperative albumin versus other fluids to prevent cardiac surgery-associated kidney injury: a systematic review and meta-analysis of randomized trials

Abstract Objective  Cardiac surgery-associated acute kidney injury is a common and serious complication of cardiac surgery. Albumin solution is a commonly administered fluid in cardiac surgery patients; the role of..

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Association between preoperative hydration and cardiac surgery-associated acute kidney injury: a prospective observational study

Abstract Background Cardiac surgery associated acute kidney injury (CSA-AKI) is a common and serious complication following cardiac surgery with cardiopulmonary bypass (CPB), associated with prolonged hospitalization, increased costs, and higher..

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Combining biomarkers with clinical risk factors to predict acute kidney injury after cardiopulmonary bypass surgery: An observational cohort study

Abstract Cardiac surgery-associated acute kidney injury (CSA-AKI) is a prevalent complication subsequent to cardiopulmonary bypass (CPB) surgery. Timely diagnosis is essential for enhancing patient outcomes. Traditional diagnostic approaches that depend..

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Retrograde Lower Body Perfusion Is Associated with Reduced Acute Kidney Injury in Stage II Palliation for Hypoplastic Left Heart Syndrome

Abstract Objective Acute kidney injury (AKI) complicates pediatric cardiac surgery, particularly in single-ventricle palliation. While retrograde lower body perfusion (LBP) has been associated with a renal-protective signal during aortic arch..

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Amino acids for the prevention of acute kidney injury after cardiac surgery: a narrative review of trials and meta-analyses

Abstract Acute kidney injury (AKI) is one of the most common serious complications after cardiac surgery. Although many causes and risk factors have been identified, effective measures to prevent AKI..

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Renal replacement therapy in patients under extracorporeal membrane oxygenation: a narrative review

Abstract Background The use of extracorporeal membrane oxygenation (ECMO) has expanded for severe respiratory and circulatory failure. Acute kidney injury (AKI) is one of the most frequent complications. Up to..

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Nitrite protects against cardiac surgery-associated acute kidney injury via inflammation suppression: insights from a rat cardiopulmonary bypass model

Abstract Cardiac surgery-associated acute kidney injury (CS-AKI) is reported in 20–30% of patients undergoing cardiac surgery, leading to poor outcomes and increased healthcare costs. Because the pathophysiology of CS-AKI remains..

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Clinical applications of oXiris membranes: Targeting inflammation and renal dysfunction in ICU patients

Abstract The oXiris membrane represents a notable advance in continuous renal replacement therapy for critically ill patients with severe infection, sepsis, and other conditions characterized by immune dysregulation. Built on..

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Push the flow—mind the micro: renal microcirculation during high-flow cardiopulmonary bypass

Abstract Acute kidney injury (AKI) remains one of the most frequent complications after cardiac surgery and is associated with nearly 40% mortality at 5 years (). These concerning outcomes have..

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Plasma from Cardiac Surgery Patients Induces Endothelial and Tubular Epithelial Cell Damage: Potential Role in Acute Kidney Injury Development—A Preliminary…

Abstract Cardiac surgery-associated acute kidney injury (CSA-AKI) is a frequent and severe complication of open-heart surgery. Although oxidative/inflammatory mechanisms are known to contribute to its pathophysiology, the circulating factors involved..

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Association between intrarenal venous flow and postoperative acute kidney injury in cardiac surgery patients following cardiopulmonary bypass: a prospective cohort…

Abstract Objective Postoperative acute kidney injury (AKI) after cardiac surgery is a major complication that worsens patient outcomes and increases healthcare costs. This study aimed to investigate the association between..

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Association of the red cell distribution with to total serum calcium ratio with severe AKI in patients undergoing cardiac surgery:…

Abstract Background Acute kidney injury (AKI) is a common complication following cardiac surgery. The RCR (ratio of RDW to total serum calcium (TSC)), which exhibits high predictive value for various..

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Exploring carboxyhemoglobin as a predictive marker of hemolysis-related CSA-AKI

Abstract Background Cardiac surgery–associated acute kidney injury (CSA-AKI) is one of the most frequent complications after cardiopulmonary bypass (CPB), in which hemolysis plays an important pathophysiological role. Carboxyhemoglobin (COHb) plays..

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Low cardiac index during periods of arterial hypotension and risk of acute kidney injury in cardiac surgery

Abstract Background Cardiac index (CI) and mean arterial pressure (MAP) are concurrent determinants of renal perfusion. Hypotension is associated with acute kidney injury (AKI), but clinical trials focused solely on..

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