Yearly Archives: 2026

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Early Predictors of Acute Kidney Injury After Pediatric Cardiopulmonary Bypass: A Retrospective Cohort Analysis

Abstract Background:  Acute kidney injury (AKI) is a frequent complication of congenital heart surgery with cardiopulmonary bypass (CPB) in pediatric patients, contributing to significant morbidity and mortality. Aim:  To determine..

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Heparin: Over 100 Years of Anticoagulation

Abstract This chapter provides an overview of heparin, including discovery, structure, mechanism of action, and principal use for anticoagulation. For over 100 years, heparin has a central role in prophylaxis..

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Detecting Heparin Contamination in Prolonged APTT with a Heparin-Resistant Solution

Abstract The activated partial thromboplastin time (APTT) assay is essential for evaluating coagulation. However, prolonged APTT may result from pathological conditions or contamination with unfractionated heparin (UFH), which can occur..

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Staged mechanical circulatory support in paediatric HIT: Bivalirudin anticoagulation across ECMO, VAD, and cardiac transplantation

Abstract Introduction Heparin induced thrombocytopenia (HIT) with in paediatric population is rare and subsequent anticoagulation management is challenging. Bivalirudin is a viable alternative to heparin for anticoagulating paediatric patients with..

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Anaemia and blood transfusion in cardiac surgery with infective endocarditis

Abstract Background Up to half of patients with infective endocarditis (IE) require cardiac surgery. Although anaemia is common, its precise prevalence, transfusion practices and impact on outcomes in surgically treated IE..

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Extracorporeal Blood Purification with CytoSorb in Patients with Shock: A Secondary Analysis of Standalone Circuit Configuration Versus Integrated Use within…

Abstract Objectives CytoSorb, an extracorporeal blood purification device composed of biocompatible, highly porous polymer beads, is being increasingly adopted in different critically ill settings to allow for both enhanced organ..

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Increasing Anticoagulation Intensity in the Oxygenator During Flow Reduction Trials in Venoarterial Extracorporeal Membrane Oxygenation

Abstract Anticoagulation is mandatory during venoarterial extracorporeal membrane oxygenation (V-A ECMO) flow reduction trials with very low blood flow. Anticoagulation in the ECMO circuit might be intensified with less effect..

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Hemodynamic monitoring: basic principles in operation room and intensive care unit

Abstract To synthesize physiological principles and practical monitoring strategies for perioperative and intensive care hemodynamics, addressing two questions: which variables should be monitored, and what targets should be pursued to..

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Moral distress of intensive care unit nurses: a systematic review and meta-analysis

Abstract Background This study aims to assess the level of ethical distress experienced by intensive care unit (ICU) nurses in their work, thereby providing a theoretical basis for the development..

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Ex Vivo Lung Perfusion (EVLP)

Ex Vivo Lung Perfusion (EVLP) has become a key strategy to assess, recondition, and safely transplant lungs from DCD (Donation after Circulatory Death) donors, particularly because of warm ischemia exposure...

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Lung-less Patient on VA ECMO waiting for Pericardial reconstructed Lung Left Atrium

An on-pump veno-arterial (VA) ECMO strategy allows safe stabilization and preparation of a lung-less patient while awaiting immediate implantation of the recipient graft. Following bilateral pneumonectomy, VA ECMO provides full..

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Perioperative Profiles of Immune Cells in Patients with Postoperative Delirium After Cardiac Surgery with Cardiopulmonary Bypass

Abstract Background: Postoperative delirium (POD) is known to involve systemic inflammatory responses, but the characteristics of the immune cell types involved in these responses are unclear.  Methods: In this prospective study, we..

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Postoperative Thrombocytopenia in Cardiac Surgery: Patterns, Differential Diagnosis and Management of Heparin-Induced Thrombocytopenia (HIT)

Abstract Background: Postoperative thrombocytopenia is a frequent finding after cardiac surgery, affecting approximately 10–40% of patients. The early decline in platelet count, typically observed within the first 48–72 h, is..

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Effects of therapeutic hypothermia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation

Abstract Background Cardiac arrest (CA) remains a leading cause of mortality and long-term neurological disability. In cases of refractory CA, extracorporeal cardiopulmonary resuscitation (ECPR) may be implemented as a salvage..

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Predicting In-Hospital Acute Kidney Injury after Cardiac Surgery Using Machine Learning

Abstract Objective We aimed to develop and evaluate cardiac surgery–associated acute kidney injury (CSA-AKI) machine learning prediction models that included clinical variables, biomarkers, and high-frequency hemodynamic measurements. Design A prospective,..

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Total Tau protein as a novel biomarker for detection of neural injury following cardiopulmonary bypass in pediatric congenital heart surgery…

Abstract Objective To investigate the association of Tau protein levels with postoperative evidence of neural injury following cardiopulmonary bypass (CPB) in pediatric cardiac surgery patients. Methods One hundred forty-four consecutive..

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Training of Emergency Medicine Residents to Initiate Extracorporeal Membrane Oxygenation Cardiopulmonary Resuscitation (ECPR)

Abstract Background The objective of our study was to evaluate the ability of Emergency Medicine (EM) physicians who have completed an accelerated extracorporeal membrane oxygenation (ECMO) course and mannequin training..

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Extracorporeal cardiopulmonary resuscitation: what does the future hold for out of hospital cardiac arrest? A narrative review and critical appraisal…

Abstract The use of extracorporeal cardiopulmonary resuscitation (ECPR) has risen exponentially worldwide. Following favorable observational studies, randomized controlled trials yielded conflicting results in patients with out of hospital cardiac arrest..

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Transesophageal echocardiography uncovers iatrogenic liver injury during minimally invasive mitral valve surgery: case report

Abstract Background Minimally invasive cardiac surgery (MICS) reduces surgical trauma but limits direct visualization of surrounding structures, posing a risk of unrecognized injury. Case presentation A 65-year-old man with alcoholic..

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Post-resuscitation care after adult extracorporeal cardiopulmonary resuscitation: A scoping review

Abstract Background Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used in adults with refractory cardiac arrest. However, post-resuscitation care in this population remains heterogeneous, evidence-based recommendations are lacking, and most evidence..

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Heparin Resistance in Cardiac Surgery with Cardiopulmonary Bypass: Mechanisms, Clinical Implications, and Evidence-Based Management

Abstract Background: Unfractionated heparin (UFH) is the standard anticoagulant during cardiopulmonary bypass (CPB). A clinically relevant subset develops heparin resistance (HR)—failure to reach adequate anticoagulation with usual UFH—raising thrombotic risk..

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Predictors of VV-ECMO weaning safety: longitudinal ventilatory ratio assessment during sweep gas off trials, a retrospective cohort study

Abstract Background Separation from venovenous extracorporeal membrane oxygenation (VV-ECMO) is a pivotal transition for patients with acute respiratory distress syndrome (ARDS). Impaired alveolar ventilation more so than oxygenation may be..

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Trauma Extracorporeal Membrane Oxygenation in Argentina: Complications, Mortality, and Long-term Outcomes

Abstract Extracorporeal membrane oxygenation (ECMO) for trauma is underreported in Latin America. We conducted a cohort study in four centers from Argentina (2015–2024), including all adults with polytrauma (defined as..

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Understanding the influence of temporary neurologic dysfunction in the outcomes of aortic surgery

Abstract Objective Temporary neurologic dysfunction (ND) is common after aortic surgery. The Valve Academic Research Consortium 3 classifies ND as NeuroARC Type 1 (stroke), Type 2 (covert injury), and Type..

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Effect of Ozone Autohemotherapy on Inflammatory Response and Postoperative Cognitive Function in Patients Undergoing Valve Replacement with Cardiopulmonary Bypass

Abstract Objective: We herein probed the effects of ozone autohemotherapy (O3-AHT) on inflammatory response and postoperative cognitive function in patients undergoing valve replacement with cardiopulmonary bypass (CPB). Methods: Totally, 130..

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Extracorporeal membrane oxygenation in a low-volume whole nation cardiothoracic centre: short- and long-term mortality, survivors` quality of life and symptoms…

Abstract Background For over three decades ECMO-treatment has been provided in our low-volume nationwide cardiothoracic centre in Iceland. This research aims to examine both the short- and long-term results of..

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Evolution of extracorporeal membrane oxygenation: historical milestones and advanced developments

Abstract Extracorporeal membrane oxygenation (ECMO) has a history that is a testament to the pioneering spirit of medical innovators. It is intricately linked with the development of cardiopulmonary bypass (CPB)..

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Percutaneous Postclosure vs Femoral Arterial Cutdown for Venoarterial Extracorporeal Membrane Cannulation Sites

Abstract Background This study sought to examine the outcomes of percutaneous postclosure of large-bore femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO) cannulas compared with a traditional open cutdown technique. Methods Between..

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Efficacy and Feasibility of Preoperative Autologous Blood Donation in Elective On-pump Cardiac Surgeries: A Propensity-score Matching Study

Abstract Objective: The global shortage of blood resources has become a significant concern. This study aimed to assess the effects and feasibility of preoperative autologous blood donation (PABD) in elective..

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Multiple faces of equity in extracorporeal membrane oxygenation

Abstract Health care is not a luxury in the sense of being an enjoyment or an unnecessary indulgence, but inequality and inaccessibility can make certain services seem like luxuries. Health..

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