Perfusfind S.L.
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Microplastics in cardiopulmonary bypass: quantification and characterization of particles across systems

Abstract OBJECTIVES This study determines the microplastic (MP) levels, dimension, shape, and chemical composition generated from conventional cardiopulmonary bypass and minimally invasive extracorporeal circulation (MiECC) circuits. METHODS In vitro conventional and..

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Intraoperative cell salvage utilization for blood conservation during pediatric and adult spinal surgery: a state-of-the-art systematic review

Abstract Purpose The purpose of this systematic review was to identify the efficacy of cell salvage in adult and pediatric spinal surgery. Methods A comprehensive systematic review of four biomedical..

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Imaging the microstructure of the arterial wall – ex vivo to in vivo potential

Abstract Microstructural imaging enables researchers to visualise changes in the arterial wall, allowing for (i) a deeper understanding of the role of specific components in arterial mechanics, (ii) the observation..

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A Randomized Trial of Acute Normovolemic Hemodilution in Cardiac Surgery

Abstract Background Patients undergoing cardiac surgery often receive red-cell transfusions, along with the associated risks and costs. Early intraoperative normovolemic hemodilution (i.e., acute normovolemic hemodilution [ANH]) is a blood-conservation technique..

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Arterial CO2 Targets in Veno-Arterial Extracorporeal Membrane Oxygenation After Cardiac Arrest

Abstract After cardiac arrest, restoration of circulation is the first step toward survivorship. Extracorporeal CPR (ECPR), the use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) to restore circulation, is increasingly being..

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Blood pressure management during cardiac surgery: a survey of Canadian cardiac anesthesiologists, perfusionists, and cardiac surgeons

Abstract Purpose Clinicians presume a relationship between the management of blood pressure during cardiac surgery and postoperative morbidity and mortality. With limited evidence to inform practice, we surveyed Canadian cardiac..

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Factors Associated With Postoperative Complications Among Critical Patients Undergoing Open-Heart Surgery: A Cross-Sectional Study

Abstract Aim To identify the factors associated with postoperative complications within the first 24 h among individuals who have undergone open-heart surgery. Design A cross-sectional study. Methods The participants were 192..

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A randomized controlled trial on the impact of anesthetic agents on renal function in cardiac surgery with cardiopulmonary bypass

Abstract Acute kidney injury (AKI) is a frequent and severe problem following heart surgery, particularly in procedures involving cardiopulmonary bypass (CPB). This research investigates the Randomized Controlled Trial (RCT) on..

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Echocardiographic and Hemodynamic Effects of Intraaortic Balloon Pump in Patients with Cardiogenic Shock on Veno-Arterial Extracorporeal Membrane Oxygenation

Abstract We investigated echocardiographic and hemodynamic effects of intraaortic balloon pump (IABP) in 26 patients with cardiogenic shock on veno-arterial membrane oxygenation (VA ECMO). Our study demonstrated an 8.1% increase..

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Effects of Artificial Lung and Roller Pump on Platelet Morphology and Activation During Simulated Extracorporeal Circulation

Abstract Introduction Prolonged extracorporeal circulation time is known to cause intraoperative and postoperative bleeding, but the underlying mechanism is not fully understood. In this study, we analyzed the effects of..

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Efficacy and Safety of Desmopressin in Terms of Bleeding and Transfusion in Cardiac Surgery With Cardiopulmonary Bypass: A Systematic Review…

Abstract Bleeding and transfusion during cardiac surgery are major sources of complications. Surgery and cardiopulmonary bypass can induce coagulopathy, including platelet dysfunction. Desmopressin has been shown to reduce bleeding and..

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Report of the Portable Ex Vivo Organ Perfusion Workforce Survey: Staffing Models and Clinical Trends

Abstract Historically, organs recovered for transplant have been transported using static cold preservation. However, newer portable ex vivo organ perfusion (PEVOP) strategies allow warm organ perfusion during transport. Although PEVOP is a..

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A Dutch nationwide pediatric cardiac arrest registry with long-term follow-up – towards an international prognostication guideline

Abstract Aims Pediatric cardiac arrest is associated with high mortality and significant morbidity among survivors. International guidelines for prognostication remain limited due to small heterogeneous patient populations, variable post-return of..

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Effectiveness of non-technical skills training in intensive care units: a systematic review

Abstract Background Non-technical skills (NTS) are social, cognitive and psychological skills that are related to safety and efficiency in the healthcare process. These skills have an important role in the..

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Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential predictors of nosocomial infection in patients undergoing veno-arterial extracorporeal membrane oxygenation: A cohort…

Abstract Objective The aim of this study was to evaluate and compare the predictive value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for nosocomial infection in patients undergoing..

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Consciousness in deep hypothermic circulatory arrest: a feasibility study

Abstract Background Studies have not explored consciousness during deep hypothermic circulatory arrest (DHCA). However, as studies in cardiac arrest have identified a spectrum of consciousness, we sought to establish the..

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Evaluating the impact of patient blood management implementation: a protocol for a quasiexperimental study in a Portuguese tertiary care setting

Abstract Introduction Patient blood management (PBM), an evidence-based, patient-centred approach for optimising blood health, faces significant implementation challenges despite regulatory support, and this study explores its adoption within a Portuguese hospital..

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Unifying Weaning Success Criteria to Bridge the Extracorporeal Membrane Oxygenation Gap: Variations in Determinants Based on Definitions of Successful Weaning

Abstract Objective To investigate the factors contributing to the "ECMO gap," the discrepancy between successful weaning from venoarterial extracorporeal membrane oxygenation (VA-ECMO) and survival to hospital discharge, using different definitions..

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Development and Testing of a Novel Simulation-Based Mastery Learning Course: Introduction to Extracorporeal Membrane Oxygenation Cannulation

Abstract A novel simulation-based mastery learning (SBML) course for extracorporeal membrane oxygenation (ECMO) cannulation—Introduction to ECMO Cannulation—was developed and tested at the Division of Cardiac Surgery at McMaster University in..

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Hemodynamic control during cardiopulmonary bypass and the incidence of postoperative delirium– a post hoc analysis

Abstract Background Delirium is a common neurological complication after cardiac surgery. The purpose of the present study was to analyze the association between hemodynamic fluctuations during cardiopulmonary bypass (CPB) and..

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Assessment of arterial whole blood redox potential during cardiopulmonary bypass

Abstract Introduction Imbalance in the redox equilibrium is common in any type of aggression. Cardiopulmonary bypass (CPB) initiation induces metabolic perturbations, and reliable biological monitoring tools for this condition are..

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Association Between Rewarming Rate and Survival and Neurologic Outcome of Accidental Hypothermia

Abstract Objectives:  Accidental hypothermia has high mortality. Rewarming is the initial primary management strategy. However, detailed evidence on rewarming management is limited, that is, rewarming rate is unclear, particularly with..

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Leveraging large language models for preoperative prevention of cardiopulmonary bypass-associated acute kidney injury

Abstract Background Acute kidney injury (AKI) usually occurs after cardiopulmonary bypass (CPB) and threatens life without timely intervention. Early assessment and prevention are critical for saving AKI patients. However, numerical..

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Functional Status Trends for Adults and Children on Extracorporeal Membrane Oxygenation at Time of Lung Transplantation

Abstract Poor or worsening functional status of lung transplant (LTx) candidates is a key risk factor for waitlist and post-transplant mortality. As more critically ill adults and children are listed..

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Anticoagulation during Extracorporeal Membrane Oxygenation (ECMO): A Selective Inhibitor of Activated Factor XII Compared to Heparin in an Ex Vivo…

Abstract Extracorporeal membrane oxygenation (ECMO) is a form of life support for critically ill patients with severe respiratory or cardiac failure. Interactions between patient blood and ECMO biomaterials increase the..

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Enhancing Survival Prediction After Venoarterial Extracorporeal Membrane Oxygenation Using Machine Learning

Abstract In-hospital mortality after venoarterial extracorporeal membrane oxygenation (VA-ECMO) remains high. This study compared the performance of the Survival after Venoarterial ECMO (SAVE) score with machine learning (ML) models incorporating..

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Impact of Noninvasive Ventilation Before and After Cardiac Surgery for Preventing Cardiac and Pulmonary Complications

Abstract Background The immediate postoperative period after heart surgery poses a substantial risk of life-threatening complications, notably acute pulmonary and cardiac failure. Use of noninvasive ventilation (NIV) may reduce the..

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Revolution in Organ Preservation: Technological Exploration

Abstract Organ preservation plays a critical role in addressing transplantation challenges, including donor shortages and ischemia-reperfusion injury (IRI). Continuous advancements in preservation technologies are essential to meet the increasing demand..

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Clinical assessment of cannula performance during adult minimally invasive valve surgery using predictive mathematical models

Abstract OBJECTIVES Peripheral cannula selection in minimally invasive cardiac surgery (MICS) is crucial, as venous drainage limitations during cardiopulmonary bypass (CPB) can impair end-organ perfusion and overall outcomes. This study..

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Vasoplegia Syndrome After Cardiac Surgery: Insights Into Mechanisms and Treatment

Abstract Vasoplegia syndrome is a specific form of vasodilatory shock encountered in patients who undergo cardiac surgery, most commonly with cardiopulmonary bypass, which is characterized by severe hypotension in the..

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