The potential benefits of monitoring oxygen delivery in relation to O2ERi and VCO2 during normothermic regional perfusion in DCD donors

As the field of organ transplantation continues to evolve, the use of Donation after Circulatory Death (DCD) donors has emerged as a critical method to expand the donor pool. However, the preservation of organs from DCD donors remains a significant challenge, primarily due to the risk of ischemic damage and subsequent organ dysfunction. Normothermic Regional Perfusion (NRP) has been introduced as a technique to mitigate these risks, restoring circulation and oxygenation in the donor organs. Within this context, the monitoring of indexed oxygen delivery (DO_2i) about Equilibrium between Required and Supplied Oxygen (O₂ERi) and carbon dioxide production (VCO₂) offers substantial potential benefits that can significantly enhance the outcomes of organ transplantation. Indexed Oxygen delivery (DO_2i) plays a pivotal role in ensuring the viability of organs during NRP. Adequate DO_2i is essential to maintain cellular metabolism and prevent ischemic injury during the period between circulatory cessation and organ retrieval. The study by de Somer et al. (2011) highlights the critical nature of maintaining optimal DO_2i levels during cardiopulmonary bypass, demonstrating that inadequate DO_2i is strongly associated with the development of acute kidney injury (AKI)