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Awake vs. Sedated Cannulation for Extra-Corporeal Membrane Oxygenation in Patients with COVID-19 Induced Acute Respiratory Distress Syndrome

Why this article matters   Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is routinely initiated in patients with severe ARDS after intubation, deep sedation, and often neuromuscular blockade. During the COVID-19 pandemic, however, some centers explored an alternative strategy: awake...

Advances in resuscitation and deresuscitation

Summary This review discusses significant recent developments in fluid resuscitation and deresuscitation practices within critical care, highlighting a paradigm shift toward conservative, personalized fluid management. Advances in fluid stewardship, goal-directed fluid therapy (GDFT), and innovative...

Driving pressure vs. oxygenation-based PEEP titration strategies in ARDS patients: a physiological study

Summary This prospective observational study compared the physiological effects of three different positive end-expiratory pressure (PEEP) titration strategies in patients with acute respiratory distress syndrome (ARDS): a driving pressure-based clinical approach, an empirical oxygenation-based...

Cardiogenic shock syndrome unraveled: understanding the different layers of heterogeneity

Summary Cardiogenic shock (CS) represents a heterogeneous clinical syndrome characterized by sustained tissue hypoperfusion due to cardiac dysfunction, encompassing diverse etiological, hemodynamic, and molecular profiles. The paper emphasizes the need for recognizing CS heterogeneity through...

Bedside Assessment of the Respiratory System During Invasive Mechanical Ventilation

Summary The article provides an in-depth review of bedside methods for assessing respiratory mechanics in patients receiving invasive mechanical ventilation. It emphasizes physiological principles guiding clinical management and differentiates between extensive and intensive ventilatory parameters...

Does targeted temperature management at 33 °C improve outcome after cardiac arrest?

Summary The article explores targeted temperature management (TTM) at 33°C as a treatment for patients following cardiac arrest, presenting arguments both in favor and against its use. TTM has been extensively debated due to conflicting clinical trial outcomes, variability in evidence from...
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