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Efficacy, Safety, and Cost-Effectiveness of Cell Salvage in Cardiac Reoperations

Abstract Background: The aim of this study was to investigate the efficacy and safety of cell salvage (CS) use in cardiac reoperations and to conduct a cost analysis considering the Turkish..

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Perioperative Anemia and Patient Blood Management in Cardiac Surgery: A Scientific Statement From the American Heart Association

Abstract Perioperative anemia and red blood cell transfusions are important risk factors for morbidity and mortality in cardiac surgery. Preoperative anemia is common, with up to 50% of patients presenting..

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Multidisciplinary blood conservation practices for transfusion-free congenital heart surgery

Abstract Team Sport The most effective method for achieving sustainable blood-sparing practices is a pragmatic and individualized approach within a multidisciplinary framework. For every case, direct, clear, and intentional communication..

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Timing matters: association of persistent postoperative anemia with adverse outcomes in cardiac surgery

Abstract Objective To investigate the dynamic impact of anemia at different perioperative timepoints (preoperative, postoperative day 1, 3, and 7) on adverse events in patients undergoing cardiac surgery. Methods This..

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Development of a hemolysis filter system for the selective removal of free hemoglobin, haem and iron from blood envisaged for…

Abstract Hemolysis, the rupture of red blood cells, releases hemoglobin, haem, and redox-active iron into the bloodstream. When the body’s scavenging capacity is overwhelmed, these species can exert deleterious effects,..

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Multi-Output Machine Learning for Prediction of Postoperative Outcomes After Cardiac Surgery Using Patient Blood Management Biomarkers

Abstract Background/Objectives: Postoperative complications following adult cardiac surgery are biologically interrelated, yet most machine learning models predict single outcomes. We developed an explainable multi-output model integrating routinely collected clinical variables..

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Preoperative IV iron and postoperative blood transfusion reduction in non-anaemic patients undergoing cardiac surgery: a systematic review and meta-analysis of…

Abstract Background Preoperative intravenous iron has become increasingly popular as a strategy to optimize hemoglobin before major surgery. However, its potential benefit in non-anaemic patients undergoing cardiac surgery remains unclear...

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Patient blood management protocol reduces allogeneic transfusion, morbidity, and mortality in coronary artery bypass surgery

Abstract Background Allogeneic blood is a limited and globally scarce resource. Protocols based on the Patient Blood Management (PBM) program, incorporating therapeutic alternatives to reduce the use of red blood..

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Plasma PF4 is a reliable biomarker of platelet reactivity and predictive of bleeding risk in DAPT patients undergoing cardiac surgery

Abstract Background Platelet activation is crucial for hemostasis and thrombosis, particularly in patients on antiplatelet therapy. Managing bleeding risk during cardiac surgery requires understanding platelet dynamics, especially when antiplatelet agents..

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Intraoperative continuous noninvasive hemoglobin monitoring in patients undergoing thoracic surgery

Abstract Background This study aims to assess the agreement between noninvasive hemoglobin (SpHb) and invasive hemoglobin (InvHb) monitoring in guiding blood transfusions during thoracic procedures. Methods This study was not..

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A highly biocompatible chip for continuous blood electrolyte detection based on hydrophilic surface modification

Abstract In the course of extracorporeal circulation (ECC), real-time monitoring of blood electrolyte levels is crucial for ensuring patient safety and improving outcomes. A continuous detection chip of blood electrolytes..

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Patient Blood Management: a systematic review of current international guidelines

Abstract Background Patient Blood Management (PBM) is a multidisciplinary strategy to optimise patient outcomes by preserving autologous blood and reducing unnecessary transfusion. Although PBM initiatives exist worldwide, the consistency of..

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How To Dose Prothrombin Complex Concentrates in Bleeding Patients After Cardiac Surgery

Abstract Coagulopathy, bleeding, and transfusion of allogeneic blood products remain major concerns in a relevant portion of patients undergoing cardiac surgery, and all of them have been associated with increased..

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Transfusion of blood products to neonatal and pediatric extracorporeal membrane oxygenation patients: A prospective, observational study

Abstract Study Question To describe the blood product utilization during neonatal and pediatric extracorporeal membrane oxygenation (ECMO) and to determine whether its usage correlates with clinical outcomes of bleeding, thrombosis..

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The case for washing red blood cells and platelets – A concise review of donors, processes, and products

Abstract Transfusions are one of the most common procedures performed in the hospital setting, but the frequency of adverse events is often not recognized. These transfusion adverse events include transfusion..

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Perioperative Patient Blood Management: Evidence-Based Strategies for Surgeons and Anesthesiologists: A Narrative Review

Abstract Patient Blood Management (PBM) has evolved from a transfusion-centered practice to a structured, patient-focused perioperative strategy aimed at improving surgical outcomes while preserving blood resources. In the operating room,..

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Effects of transcutaneous auricular vagus nerve stimulation or combined vagal and trigeminal nerve stimulation on platelet function and laboratory hemostasis…

Abstract Background Traumatic or surgical hemorrhage causes substantial morbidity and mortality. Electrical vagus nerve stimulation (VNS) reduces traumatic hemorrhage in animal models. VNS targets acetylcholine-producing T lymphocytes in the spleen..

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Perioperative blood management in Jehovah’s Witnesses

Abstract Background Jehova′s Witnesses refuse the administration of allogenic blood products for religious reasons. This stance represents a special challenge for the perioperative management and requires individualized ethically sensitive and..

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Combined Platelet and Red Blood Cell Salvage During Cardiac Surgery

Abstract Patient blood management (PBM) aims to improve patient outcome by managing and preserving a patient’s own blood and its components. Among the many recommended interventions, reducing intraoperative blood loss..

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Thrombocytopenia After Cardiac Surgery: A Single-Center Retrospective Study

Abstract Background: Postoperative thrombocytopenia is a frequent complication in cardiac surgery, associated with increased morbidity and mortality. Our study aimed to describe platelet count after cardiac surgery and identify predictors..

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Use of andexanet alfa: A British Society for Haematology position statement

Abstract Andexanet alfa (Ondexxya) currently holds UK marketing authorisation (MA) for adult patients treated with a direct factor Xa (FXa) inhibitor (apixaban or rivaroxaban) when reversal of anticoagulation is indicated..

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Impact of an Autotransfusion Device on Platelet Count and Transfusion Requirements in Cardiac Surgery: An Observational Study

Abstract Objectives To compare postoperative platelet counts in patients in whom intraoperative cell salvage (ICS) was performed using either a centrifugation-based device (ICS-centrifugation) or a filtration-based device (ICS-filtration; Same) for..

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A Cohort, Semi-Randomized, open label quality improvement patient blood management (PBM) comparison of point of care viscoelastic coagulation monitors in…

Abstract Viscoelastic testing (VET), recommended for heart surgery, lacks adoption due to data reporting times (central laboratory coagulation assay-CLCA and laboratory VET tests) and interpretation (predicate VET devices). Three point..

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Program of quality improvement for extracorporeal blood purification therapies in the intensive care unit

Abstract Critically ill patients often require complex extracorporeal treatments, such as extracorporeal blood purification (EBP). At the bedside, there can be reluctance or uncertainty about when to initiate EBP, and..

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Hemocompatibility of Emergency Bypass System versus Permanent Life Support extracorporeal membrane oxygenation in a propensity score-matched cohort: analysis of hematologic…

Abstract Background The Emergency Bypass System (EBS, Terumo Corporation) and Permanent Life Support (PLS, MAQUET Cardiopulmonary GmbH) platforms differ in pump design and surface coating, which may influence hemocompatibility. This study..

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Engineering tough blood clots for rapid haemostasis and enhanced regeneration

Abstract Blood clots are pivotal for haemostasis and regeneration, but they are mechanically weak and form slowly, posing risks for life-threatening haemorrhage and limiting broader applications,,. These limitations are attributed..

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Association between platelet indices and next-day bleeding and clotting in children and adults on extracorporeal membrane oxygenation: A retrospective study

Abstract Introduction Bleeding and clotting phenotypes are common in patients supported with Extracorporeal Membrane Oxygenation (ECMO) and are associated with increased mortality. However, tools to distinguish bleeding from clotting phenotypes..

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Improving bleeding and thrombosis in patients with extracorporeal life support: could hematology help?

Abstract Despite the advances in technology, new patient populations, new medications, and multiple monitoring algorithms for anticoagulation, bleeding, and thrombosis complications remain high among those receiving extracorporeal life support (ECLS)..

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Quality management of comprehensive blood conservation strategies during cardiopulmonary bypass in pediatric cardiac surgery

Abstract Background Pediatric cardiac surgery with cardiopulmonary bypass (CPB) carries substantial transfusion requirements, exposing patients to increased risks of complications during hospital stay. This study evaluates the clinical impact of..

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Perioperative blood loss in cardiac surgery: Validation of machine learning-derived clusters

Abstract Background There is no universally accepted definition of perioperative blood loss in cardiac surgery. Existing methods are based on chest tube output and are not normalised for patient weight...

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