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Efficacy and safety of postoperative autologous blood transfusion in cardiac surgery (RESCUE): Rationale, design, and study protocol of a multicenter…

Abstract Background Postoperative bleeding is a major concern in cardiac surgery, often leading to significant transfusion requirements. Despite this high transfusion demand, the use of postoperative autologous blood transfusion (PABT)..

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Revisiting the safety of intraoperative cell salvage in cancer surgery: how to evaluate the functional properties of remaining cancer cells

Abstract Cancer surgery accounts for a substantial proportion of allogeneic blood use. As demographic changes lead to a growing number of oncologic procedures, transfusion demands are increasing, while blood supply..

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A Perioperative Blood Conservation Protocol to Achieve Successful Bloodless Heart Transplantation

Abstract Heart transplantation (HT) is the definitive therapy for end-stage heart failure. Patients unwilling to receive blood product transfusions are often considered ineligible for HT due to the significant perioperative..

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Bleeding Complications from Chest Tube Treatment in Patients on Extracorporeal Membrane Oxygenation Support

Abstract Objectives Bleeding is a common complication of extracorporeal membrane oxygenation (ECMO) support. While chest tube treatment is infrequently linked to bleeding in non-ECMO patients, several reports suggest a markedly..

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Compliance with ESAIC guidelines for fibrinogen concentrate prescription in cardiac surgery: a multicentre French cohort study

Abstract Background Fibrinogen concentrate may reduce allogeneic blood product transfusion in cardiac surgery patients with bleeding associated with acquired hypofibrinogenemia. The European Society of Anaesthesiology and Intensive Care (ESAIC) has..

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From Pandemic to Practice: How COVID-19 Has Reshaped Haemostasis in Cardiac Surgery: A Narrative Review

Abstract The utilisation of cardiopulmonary bypass (CPB) during cardiac surgery is often associated with complex haemostatic perturbations, frequently manifesting as a paradoxical risk of both bleeding and thrombosis. This is..

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Preservation of Platelet Function After Intraoperative Cell Salvage Using the i-SEP Same Device in Cardiac Surgery

Abstract Objectives To evaluate whether platelet function is preserved after intraoperative autotransfusion using the Same system, a device designed to retain both red blood cells and platelets in patients undergoing..

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Alternate functions of physiological anticoagulants

Abstract The anticoagulant proteins antithrombin, protein C, protein S, and tissue factor pathway inhibitor are physiological regulators of the blood coagulation pathway and have complex roles in causing or modifying..

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Shear-induced dysregulation of haemostasis during extracorporeal membrane oxygenation: From cells to circuit

Abstract Extracorporeal membrane oxygenation (ECMO) is increasingly being utilized in critical care globally to allow for adequate oxygenation in patients with cardiac and/or respiratory failure. Unfortunately, haemostatic complications – both..

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Transfusion thresholds and other strategies for guiding red blood cell transfusion

Abstract Background The optimal haemoglobin threshold for use of red blood cell (RBC) transfusions in anaemic patients remains an active area of research. Blood is a limited resource, and there..

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3D Membrane Microstructures for Increased Efficiency in Blood-Gas Transfer

Abstract Treating severe lung diseases with extracorporeal membrane oxygenation (ECMO) is often accompanied by serious complications, restricting applicability and adversely affecting outcomes. Membrane oxygenators, based on hollow fiber membranes (HFM),..

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Plasma fibrinogen level and severe bleeding in cardiac surgery: an observational post hoc study of the ALBICS trial

Abstract Purpose Fibrinogen is widely used in cardiac surgery. Still, reported associations between plasma fibrinogen level and chest tube drainage are weak. The results of trials on fibrinogen supplementation are..

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Mitigating the adverse haematological consequences of extracorporeal membrane oxygenation

Abstract Pumping blood through an extracorporeal membrane oxygenation (ECMO) circuit in critically ill patients inevitably leads to a pathophysiological response characterized by platelet and procoagulant activation, fibrin deposition, and immunomodulation. This..

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Predictors of postoperative bleeding in pediatric cardiac surgery under cardiopulmonary bypass: a comparative study of thromboelastography parameters and central laboratory…

Abstract Purpose Postoperative bleeding is a major concern in pediatric cardiac surgery under cardiopulmonary bypass (CPB). The comparative utility of viscoelastic testing and central laboratory assays for predicting bleeding risk..

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Intraoperative cell-salvaged versus allogeneic red blood cell transfusions in high-bleeding-risk cardiovascular surgery: Protocol for a single-center, randomized, parallel-group, noninferiority trial

Abstract Introduction Patients who undergo cardiac surgery have a high risk of significant blood loss and anemia. While allogeneic red blood cell (RBC) transfusions are effective, they are associated with..

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Efficacy and safety of tranexamic acid in cardiac surgery: a systematic review and network meta-analysis

Abstract Background Tranexamic acid (TXA) is recommended for reducing blood loss and transfusion in cardiac surgery. However, there are concerns regarding the safety profile of TXA, especially its proconvulsant effects...

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Death and new disability following bleeding complications during venoarterial extracorporeal membrane oxygenation. A prospective cohort study from the EXCEL registry

Abstract Introduction Bleeding events are common during the provision of Venoarterial ECMO (VA ECMO). Previous observational has suggested that these bleeding events are associated with an increased risk of in-hospital..

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Effect of intraoperative cell salvage on postoperative blood transfusion demand outcomes in cesarean section with placenta previa: a retrospective study…

Abstract Background This study aimed to analyze the postoperative blood transfusion demand and safety of intraoperative cell salvage (ICS) without leukocyte depletion filters in cesarean sections complicated by placenta previa...

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Does Autologous Platelet-Rich Plasma Improve Blood Conservation and Postoperative Outcomes in Acute Type A Aortic Dissection Surgery? A Systematic Review…

Abstract Objectives To evaluate whether autologous platelet-rich plasma (aPRP) improves blood conservation and postoperative outcomes in emergency surgery for acute type A aortic dissection (ATAAD). Design Systematic review and meta-analysis..

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Characteristics Associated with Mortality in 623 Patients Who Received Recombinant Factor VIIa for Bleeding in Cardiac Surgery

Abstract Objectives Activated recombinant factor VII (rFVIIa) has been used to treat cardiac surgical bleeding in an off-label manner. Due to the high risk of mortality with ongoing hemorrhage, assessing..

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Current State of Patient Blood Management in Cardiovascular Surgery: Insights from a Survey of Leading Centers

Abstract Objective To determine the state of patient blood management (PBM) practice in leading US cardiac surgery centers. Design A survey tool addressing PBM program structure and PBM program operations..

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Patient blood management for patients undergoing cardiac surgery in Middle Eastern countries: Multicenter survey

Abstract Background:  The purpose of this survey was to delineate and compare patient blood management (PBM) approaches in cardiac surgery across nine Middle Eastern countries while identifying the main challenges..

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Risk factors associated with the use of red blood cells in elective cardiac surgeries: A patient blood management (PBM) view

Abstract Background Blood is a biological, irreplaceable, and perishable resource, provided through voluntary, altruistic, and free donation in Brazil. Although blood components are widely used in hospital settings, several challenges..

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Impact of Low Hematocrit on On-Pump Coronary Artery Bypass Graft Surgery Outcomes

Abstract Background: Low hematocrit level is a hematological problem that is frequently encountered during cardiopulmonary bypass (CPB) in patients undergoing on-pump coronary artery bypass grafting (CABG). This study aimed to..

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Reducing perioperative red blood cell transfusion in adult aortic surgery: innovative application and process optimization of autologous plateletpheresis

Abstract Purpose Coagulopathy is a common perioperative complication in aortic surgery, increasing the risk of bleeding and transfusion requirements. This study aimed to evaluate the impact of autologous plateletpheresis on..

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Intraoperative antithrombotic drug removal during heart transplantation: A case series from the International Safe and Timely Antithrombotic Removal (STAR) registry1

Abstract Background Patients on heart transplant waiting lists are often on antithrombotic (AT) drugs. Emergency orthotopic heart transplantation (OHT) when performed on such patients without optimal washout periods increases the..

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Novel Aspiration Thrombectomy and Blood Reinfusion System for Acute Intermediate-Risk Pulmonary Embolism: AVENTUS Trial Results

Abstract Background  has become a first-line adjunctive therapy for  in patients with acute intermediate-risk  (PE). This prospective study evaluated the safety and efficacy of percutaneous mechanical  with autologous blood reinfusion using the next-generation..

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Intraoperative Cell Salvage for Revision Hip Arthroplasty

Abstract Background:  Revision hip arthroplasty is associated with significant blood loss and a subsequent need for blood transfusion. Intraoperative cell salvage (ICS) is a method of recovering a patient’s blood..

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Clinical application and research progress of platelet-rich plasma

Abstract Objective This systematic review aims to evaluate the extensive application of platelet-rich plasma (PRP) as a novel autologous cell therapy across various clinical disciplines in recent years. Method A..

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Evolving perspectives on blood transfusion in obstetric hemorrhage: a narrative review

Abstract Globally, postpartum hemorrhage is still among the most significant factors in preventable maternal morbidity and mortality. Although early recognition and intervention have improved with advances in obstetric care, transfusion..

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