Monthly Archives: junio 2026

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Optimizing Heparin and Protamine Dosing During Cardiopulmonary Bypass Using Activated Clotting Time-Guided Protocols: A Single-Centre Prospective Randomized Controlled Trial

Abstract Objectives To evaluate whether an activated clotting time (ACT)-guided, formula-based anticoagulation strategy supported by viscoelastic coagulation monitoring (ROTEM) improves perioperative coagulation management and reduces bleeding compared with standard weight-based..

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Palliative Extracorporeal Membrane Oxygenation Decannulation: An Ethical, Evidence-Based Approach

Abstract Background Extracorporeal membrane oxygenation, although lifesaving, is invasive. Complications affecting all body systems mandate reevaluation of goals of care. When extracorporeal membrane oxygenation is nonbeneficial, planning for de-escalation/decannulation to..

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Patient-reported outcome and experience measures in post-ECMO follow-up: a scoping review

Abstract Objectives To map the use of patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) in adult follow-up after extracorporeal membrane oxygenation (ECMO), and to identify measurement gaps relevant..

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Extracorporeal Membrane Oxygenation Cannulation and Early Management in the Emergency Resuscitation Room Versus Intensive Care Unit: Single-Center Experience

Abstract In this single-center retrospective cohort study, we compared extracorporeal membrane oxygenation (ECMO) cannulation and early management performed in the emergency resuscitation room (ERR) versus the intensive care unit (ICU)...

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Use of whole blood in pediatric congenital heart surgery

Abstract Objectives Cardiopulmonary bypass is necessary for surgical repair of complex congenital heart disease. We studied whether whole blood use in circuit prime and for initial intraoperative transfusion needs improved..

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Cerebro‑Cardiovascular Coupling During Extracorporeal Membrane Oxygenation Using Cerebral Oxygenation, Doppler Flow, and Echocardiography

Abstract Cerebral injury remains a major contributor to morbidity and mortality in VA‑ECMO patients. Disruption of cerebral autoregulation during extracorporeal support may predispose to neurological damage. This prospective study evaluated..

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Electrical Impedance Tomography Reveals Venoarterial Extracorporeal Membrane Oxygenation Flow-Induced Ventilation-Perfusion Mismatch

Abstract An obese female patient with ischemic cardiomyopathy was placed on venoarterial extracorporeal membrane oxygenation (VA-ECMO) for cardiogenic shock after in-hospital cardiac arrest. Despite biventricular recovery by day 3, VA-ECMO..

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The Relationship Between the Preoperative Gut Microbiome and Systemic Inflammatory Response Syndrome After Cardiac Surgery: A Prospective Cohort Study

Abstract Objectives To determine whether preoperative intestinal microbiome characteristics are associated with the development of systemic inflammatory response syndrome (SIRS) after cardiac surgery. Design Single-center prospective observational cohort study. Setting..

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Interfacial Pathway in EAS-Modified PMP Membranes Synergistically Enhances CO2/O2 Selectivity for ECMO

Abstract Efficient and selective gas transport across soft and nonporous interfaces remains a pivotal challenge for biomimetic membrane design, particularly in extracorporeal membrane oxygenation (ECMO) systems. Here, we report a..

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Characterization of Ventilator-Associated Pneumonia in Patients Receiving Extracorporeal Membrane Oxygenation Support

Abstract In this retrospective cohort study at a quaternary referral hospital, 829 adult patients supported by extracorporeal membrane oxygenation (ECMO) between January 1, 2014, and October 31, 2024, were screened..

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Survival After Extracorporeal Membrane Oxygenation Decannulation Due to Poor Prognosis in Children—An Extracorporeal Life Support Organization Registry Study

Abstract Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for critically ill children. However, decisions regarding discontinuation due to poor prognosis remain ethically complex. While outcomes after successful weaning are..

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Leukocytes in atrial fibrillation: mechanisms and therapeutics

Abstract Atrial fibrillation (AF) is a highly prevalent arrhythmia and a major cause of morbidity and mortality. Although AF is not a primarily immunologic disorder, increasing clinical, translational, and experimental..

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Resuscitative Transesophageal Echocardiography Simulation Based Education for Extracorporeal Cardiopulmonary Resuscitation Cannulation Guidance

Abstract Extracorporeal membrane oxygenation (ECMO) cannulation during refractory cardiac arrest has become a key therapeutic option in contemporary critical care medicine. When initiated in a timely manner, extracorporeal cardiopulmonary resuscitation..

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Mechanical circulatory support strategy in post–myocardial infarction ventricular septal defect repair

Abstract Post–myocardial infarction (PMI) ventricular septal defect (VSD) repair is associated with high mortality., The pathophysiology varies based on the size of the infarction and the VSD, which results in..

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A Novel Extracorporeal Membrane Oxygenation System With Enhanced Hemocompatibility and Long-Term Stability

Abstract To optimize and evaluate the hydrodynamic performance and gas exchange efficiency of a newly developed centrifugal blood pump and membrane oxygenator for extracorporeal membrane oxygenation (ECMO) support, blood pump..

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Mean arterial blood pressure during the first 24 hours after cardiac surgery and acute kidney injury: an observational cohort study

Abstract Objective(s): Mean arterial pressure (MAP) after cardiac surgery may contribute to acute kidney injury (AKI). We sought to identify threshold MAP values during the first 24 hours (h) postoperatively..

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REANIMATE 12 - Nov 18/19

Learn ECMO, ECPR, and Bleeding Edge Resuscitation A sim lab, a procedure lab, and one-on-one teaching so you can initiate ECMO and perform the most advanced hemodynamic resuscitation on your..

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Adult ECMO Simulation Course - April 12/15

This course is designed for learners who have completed the ELSO Virtual ECMO Training Course, ELSO Foundations: Adult ECMO Training Course, or for practitioners with a strong foundational knowledge of..

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Lactate and pH as Predictors of In-Hospital Mortality in Extracorporeal Cardiopulmonary Resuscitation: A Single-Center Retrospective Study

Abstract Objectives Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly employed for patients with refractory cardiac arrest, yet optimal criteria for patient selection remain poorly understood. Pre-cannulation lactate and pH values are..

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Platelets in Children: Physiological Function, Developmental Regulation, and Clinical Significance in Disease States

Abstract Platelets play a fundamental role in hemostasis; however, their phenotype, reactivity, and function vary across the pediatric age spectrum. While developmental differences in plasma coagulation proteins have been well-characterized..

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How to monitor and manage unfractionated heparin in practice (Part 1)? Guidance from the SSC of the ISTH

Abstract The International Society on Thrombosis and Haemostasis (ISTH) recently published a survey on the management of unfractionated heparin (UFH), which revealed substantial heterogeneity in practice and highlighted the need..

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Protecting the DCD lung: the importance of inmediate atrial decompression

      Dr.Sam Zeraatian Nejad Davani, Cardiovascular and Thoracic Surgeon, Transplant and Thoracic Organs Recovery Surgeon. Director of Georgia Atlanta Procure on Demand Thoracic Organs Transplant and Procurement Surgery. ..

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Venous first double TA-NRP in extended warm-ischemia DCD

    In Thoracoabdominal Normothermic Regional Perfusion (TA-NRP) for Donation after Circulatory Death (DCD), initiating central cannulation with a venous-first approach serves as a critical step to decompress an acutely..

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Early active normothermia versus no temperature control in a porcine model of extracorporeal cardiopulmonary resuscitation

Abstract Aim Early downward temperature drift is a common event of pre-hospital extracorporeal cardiopulmonary resuscitation (e-CPR), since prehospital extracorporeal membrane oxygenation (VA-ECMO) circuits often lack heat-exchangers. However, whether this core..

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Relative hematocrit declines at the time of transfusion and postoperative outcomes after coronary artery bypass grafting: a retrospective cohort study

Abstract Background Despite advances in patient blood management, the optimal hemoglobin threshold for Red Blood Cell (RBC) transfusion remains controversial. This observational study evaluated the association between the relative decline..

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Influence of microaxial flow pump level on haemolysis and kidney injury in patients with cardiogenic shock: a retrospective study

Abstract Aims Acute kidney injury (AKI) is common in patients treated with microaxial flow pumps (mAFP). Plasma-free haemoglobin (PFHb) due to haemolysis is known to increase kidney injury in a..

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Acute Kidney Injury After Cardiac Surgery in Low‑ and Middle‑Income Countries

Abstract Background: Cardiac‑surgery‑associated acute kidney injury (CSA‑AKI) is a frequent postoperative complication worldwide and is associated with increased mortality, prolonged intensive care unit stay, and substantial resource utilization. While reported..

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Early Decline in Serum Haptoglobin During Impella CP Support Compared With Intra‐Aortic Balloon Pump in Cardiogenic Shock: A Single‐Center Observational…

Abstract Background Hemolysis is a recognized complication of mechanical circulatory support and may contribute to acute kidney injury in patients with cardiogenic shock. Early hemolysis during Impella support, particularly compared..

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Considerations and future challenges in managing ECMO for pediatric patients

Abstract In managing ECMO, preventing thrombus formation and hemolysis is crucial. While centrifugal pumps are increasingly used in pediatric ECMO, pumps designed for low flow range are not approved in..

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Haematocrit During Cardiopulmonary Bypass and Risk for Acute Kidney Injury: An Observational Single-Centre Study

Abstract Objectives Low haematocrit during cardiopulmonary bypass is a known risk factor for acute kidney injury, but it is unclear whether high haematocrit also increases acute kidney injury risk. We..

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