Abstract Pulmonary capillary endothelial cells (ECs) form a highly specialized vascular interface that sustains gas exchange and organismal survival across species. Recent advances in single-cell transcriptomics and lineage tracing have..
Read MoreAbstract Background Inadequate oxygen perfusion during cardiac surgery increases risk of postoperative complications. In order to optimize perfusion strategies, the aim of this exploratory study was to investigate oxygen delivery,..
Read MoreAbstract The intrinsic cardiac nervous system (ICNS) is a key node in heart-brain communication and an emerging target for cardiac therapy, yet its physiological importance and functional organization remain poorly..
Read MoreAbstract BACKGROUND: Validation of the Quantra QPlus sonorheometry cartridge (Hemosonics Corporation) in cardiac surgical patients is limited. The primary aim of our study was to quantify the accuracy of the..
Read MoreAbstract Introduction Congenital Heart Disease (CHD) remains a major health challenge globally, with surgical interventions being the primary treatment modality for many defects. While advancements in cardiac surgery have improved..
Read MoreAbstract Introduction Pre-operative anaemia is associated with adverse outcomes following cardiac surgery. However, the prognostic impact of postoperative anaemia is characterised incompletely. We examined whether anaemia at hospital discharge independently..
Read MoreAbstract Background This study aimed to evaluate in-hospital mortality and to identify predictors of mortality in coronary artery bypass grafting (CABG) patients receiving veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support. Methods..
Read MoreAbstract Objectives To describe perioperative transfusion rates, hospital variability, temporal trends, and the association between red blood cell (RBC) transfusion and predefined risk factors in Dutch cardiac surgery. Design Nationwide..
Read MoreAbstract Background Postoperative bleeding is a common and potentially life-threatening complication following cardiac surgery, often exacerbated by multifactorial coagulopathy from cardiopulmonary bypass, hypothermia, and platelet dysfunction. While fresh frozen plasma..
Read MoreAbstract Extracorporeal cardiopulmonary resuscitation for refractory out‐of‐hospital cardiac arrest is increasingly used, with survival rates up to ≈30% reported in select highly organized systems, although outcomes vary widely across programs...
Read MoreAbstract Objective: To explore the predictive value of intraoperative oxygen delivery (DO2) and renal regional oxygen saturation (rSO2 ) during cardiopulmonary bypass (CPB) for cardiac surgery-associated acute kidney injury (CS-AKI)..
Read MoreAbstract Patients undergoing salvage cardiac surgery experience markedly elevated mortality, often exceeding the risk predicted by the Society of Thoracic Surgeons Predicted Risk of Mortality score. These patients are typically..
Read MoreAbstract Background Pulmonary complications after coronary artery bypass surgery continue to be a significant problem, affecting 5–20% of patients, prolonging hospital stays and increasing costs. In this study, we investigated..
Read MoreAbstract Acute kidney injury (AKI) is one of the most common serious complications after cardiac surgery. Although many causes and risk factors have been identified, effective measures to prevent AKI..
Read MoreAbstract Objective To describe postoperative outcomes with the use of partial CPB for thoracoabdominal aortic repair. Methods We included all the patients who underwent programmed thoracoabdominal aortic procedures in which..
Read MoreAbstract Background Readiness for venoarterial-extracorporeal membrane oxygenation (VA-ECMO) decannulation after extracorporeal cardiopulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) remains poorly defined. Objectives The objective of the study was to..
Read MoreAbstract Background There is limited clinical data to guide surgical decisions for ACC with extensive carinal involvement in the left main bronchus. In this case, it is shown that median..
Read MoreAbstract Background Determination of brain death/death by neurologic criteria (BD/DNC) in patients supported with extracorporeal membrane oxygenation (ECMO) is particularly challenging due to extracorporeal carbon dioxide clearance, which may interfere..
Read MoreAbstract Left ventricular (LV) overload is a recognized complication of venoarterial extracorporeal membrane oxygenation (VA-ECMO), but pediatric decompression remains technically challenging and poorly standardized. The atrial flow regulator (AFR) (Occlutech) is..
Read MoreAbstract Topic Importance Extracorporeal membrane oxygenation (ECMO) is a relatively novel, intensive medical intervention. It is known to raise important yet unsettled ethical concerns. Overview We established the ECMO Ethics..
Read MoreAbstract Background Deep hypothermic circulatory arrest (DHCA) is widely used in proximal thoracic aortic surgery; however, its association with subclinical cerebral ischemic changes remains poorly understood. Diffusion-weighted magnetic resonance imaging..
Read MoreAbstract Purpose: Recirculation is a critical issue in veno-venous extracorporeal membrane oxygenation (VV ECMO). We propose a novel method for estimating the recirculation ratio using temporary sweep-gas control. Methods: A circuit simulating..
Read MoreHemolysis in ECMO: More Than Just a Laboratory Finding Hemolysis remains one of the most challenging complications during ECMO support, impacting patient outcomes, circuit performance, and multidisciplinary decision-making. Understanding..
Read MoreHayatı Geri Getirmek Bir Ekip İşidir Her yıl milyonlarca insan ani kardiyak arrest, ağır travma, şok ve kritik hastalık nedeniyle yaşam mücadelesi veriyor. Bugün biliyoruz ki başarılı resüsitasyon; tek bir..
Read MoreAbstract Artificial intelligence (AI), predictive analytics, and digital health technologies are progressively reshaping extracorporeal circulation and perioperative cardiovascular care. In this evolving landscape, cardiopulmonary bypass management is transitioning from a..
Read MoreAbstract Recirculation reduces the efficiency of venovenous extracorporeal membrane oxygenation (V-V ECMO), but patient-specific determinants of recirculation and the feasibility of recirculation-guided flow adjustment are not well defined. In this..
Read MoreAbstract Unfractionated heparin (UFH) has long been an anticoagulant of choice. Despite the increasing use of low molecular weight heparin derivatives and more recently direct oral anticoagulants, UFH is still..
Read MoreAbstract In children, validated tools to monitor anaesthetic depth are lacking. In routine practice, dosing of volatile agents relies on surrogate markers such as minimum alveolar concentration and autonomic responses. In..
Read MoreAbstract Background Frozen plasma (FP) is the standard haemostatic therapy after cardiopulmonary bypass, but recent trials indicate that FP is inferior to four-factor prothrombin complex concentrate (PCC). Citrate content may..
Read MoreAbstract Multimodal neurologic prognostication (MM-NP) after cardiac arrest has been shown to enhance prognostic accuracy, however, it is vastly underutilized in real-world settings. Guideline-discordant practices and healthcare disparities in post-cardiac..
Read More























