Monthly Archives: marzo 2026

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Veno-arterial-venous Extracorporeal Membrane Oxygenation with a Hemoconcentrator to Manage Transfusion Associated Hyperkalemic Arrest

Abstract Liver transplantation (LT) is an established therapy for patients with end-stage liver disease. Advances in surgical technique, anesthetic management, and standardization of perioperative care have significantly improved outcomes, making..

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Hemoperfusion integrated into the cardiopulmonary bypass circuit modifies perioperative inflammatory trajectories

Abstract Background: Hemoperfusion has emerged as a potential extracorporeal blood purification strategy for attenuating inflammation during cardiopulmonary bypass (CPB), but perioperative biomarker trajectory data remain limited. This pilot comparative study..

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Predictors of Prolonged ICU Stay After Isolated CABG: The Role of MiECC

Abstract Background and Objectives: Prolonged intensive care unit (ICU) stay following coronary artery bypass grafting (CABG) remains a major clinical challenge. The aim of this study was to identify preoperative..

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Comparative Performance of Oxygenators for Extracorporeal Membrane Oxygenation in Adults: A Retrospective Analysis

Abstract Extracorporeal membrane oxygenation (ECMO) is a vital therapy for patients with severe cardiac and pulmonary failure. Despite technological advances, oxygenator dysfunction remains common, yet comparative clinical data across devices..

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Extracorporeal membrane oxygenation in pediatric cardiac surgery: retrospective survival analysis

Abstract Background Extracorporeal membrane oxygenation (ECMO) is a life-saving therapeutic modality in children. Outcome is multifactorial with debates regarding predictors of weaning success and mortality. Objective To explore predictors of..

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Modified Ultrafiltration and Association with Outcomes after Neonatal Cardiac Surgery

Abstract BACKGROUND We sought to determine if modified ultrafiltration (MUF) in the current era was associated with improved outcomes after neonatal cardiopulmonary bypass (CPB). METHODS Retrospective analysis of the PC4/NEPHRON..

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Immunothrombotic Dysregulation in Pediatric Patients Receiving Veno-arterial ECMO After Cardiac Surgery: Insights From Platelet Activation and T Cell Immune Profiling

Abstract Background: Numerous studies have demonstrated that both cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) are often associated with adverse outcomes or immune dysregulation when platelet counts decline during..

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Circuit-Directed Nitric Oxide in Anticoagulation-Contraindicated Adult Extracorporeal Membrane Oxygenation: A Single-Center Case Series

Abstract Oxygenator thrombosis is a major complication during extracorporeal membrane oxygenation (ECMO), but systemic anticoagulation may be contraindicated by active hemorrhage, recent surgery, intracranial injury, or severe coagulopathy. Circuit-directed nitric..

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Levosimendan During VA-ECMO for Cardiogenic Shock: An Updated Systematic Review and Meta-analysis Including the LEVOECMO Trial

Abstract Background Levosimendan is often given during venoarterial extracorporeal membrane oxygenation (VA-ECMO) support with the intention of facilitating weaning. The available evidence, however, has been derived largely from nonrandomized studies..

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A methylene blue based electrochemical assay to quantify haemoglobin in blood for point-of-care anaemia diagnosis

Abstract Anaemia is a blood disorder that affects individuals of all ages, genders, and ethnicities. It results from a decrease in the number or functionality of erythrocytes or haemoglobin (Hb),..

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Thrombin generation parameters provide independent information on plasma coagulation potential in pediatric patients on extracorporeal membrane oxygenation: a prospective, single-center…

Abstract Background Extracorporeal membrane oxygenation (ECMO) provides circulatory and respiratory support in pediatric patients with life-threatening organ failure but can alter coagulation. Objectives To assess the relationship between a plasma..

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Temperature-adjusted perfusion-metabolic phenotyping during cardiopulmonary bypass: An exploratory study

Abstract Introduction Goal-directed perfusion during cardiopulmonary bypass (CPB) has traditionally focused on indexed oxygen delivery (DO2i), yet metabolic behavior during aortic cross-clamping likely reflects a more complex interaction among oxygen..

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Propofol-Supplemented Cardioplegic Solution Effect on Myocardial Protection: A Systematic Review and Bayesian Meta-analysis of Randomized Controlled Trials

Abstract Objectives To determine the probability of a clinically relevant reduction in postoperative myocardial injury following the use of propofol-supplemented cardioplegia. Design Systematic review and Bayesian meta-analysis. Setting Perioperative cardiac..

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Leukocytes in atrial fibrillation: mechanisms and therapeutics

Abstract Atrial fibrillation (AF) is a highly prevalent arrhythmia and a major cause of morbidity and mortality. Although AF is not a primarily immunologic disorder, increasing clinical, translational, and experimental..

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From general guidance to surgical reality: Adapting the heparin-induced thrombocytopenia algorithm for cardiac surgery

Abstract Unfractionated heparin (UFH) exposure before cardiac surgery is ubiquitous. Patients who undergo urgent coronary surgery have almost invariably received intravenous UFH, and patients who undergo elective surgery receive it..

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Extracorporeal membrane oxygenation in children after Fontan operation

Abstract Objective To investigate the outcomes of pediatric patients requiring extracorporeal membrane oxygenation (ECMO) after the Fontan operation. Methods We conducted a retrospective cohort analysis of the Extracorporeal Life Support..

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Protocol and Statistical Analysis Plan for the ECMO-Free Trial

Abstract Background Decannulation from venovenous extracorporeal membrane oxygenation (ECMO) at the earliest safe opportunity would be expected to improve patient outcomes. Currently, the manner in which clinicians liberate patients from..

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Center Experience, Learning Curves, Run Durations, and Outcomes in Venovenous Extracorporeal Membrane Oxygenation

Abstract Background The expanding availability of venovenous extracorporeal membrane oxygenation (ECMO) and the increasing frequency of prolonged ECMO runs challenge standard definitions of center experience based solely on patient counts...

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Quality of Life After Cardiac Surgery: The QUACS Study and Benefit Prediction Model

Abstract Objectives Safer cardiac surgery is being offered to more high-risk and frail patients, improving both survival and quality of life (QoL) for most. The QoL After Cardiac Surgery Study..

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Edinburgh NRP Masterclass - 18/20 Nov

Edinburgh NRP Masterclass – 18th-20th November 2026 An intensive three-day masterclass in abdominal Normothermic Regional Perfusion, combining expert-led teaching, practical simulation and hands-on training. Bringing together a multidisciplinary international faculty..

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Outcomes in Obese Adult Venoarterial Extracorporeal Membrane Oxygenation: A Systematic Review

Abstract Historically, extracorporeal membrane oxygenation (ECMO) in critical illness and respiratory failure has been used cautiously in patients with morbid obesity. However, recent data show favorable mortality outcomes for higher..

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Increasing utilization of extracorporeal membrane oxygenation and its association with venous thromboembolism following lung transplant

Abstract Background Venous thromboembolism (VTE) is a common complication following lung transplantation, and perioperative extracorporeal membrane oxygenation (ECMO) use has increased substantially over time. The relationship between ECMO exposure and..

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Extracorporeal membrane oxygenation may prevent preterm cerebral atrophy in survivors of acute respiratory distress syndrome: a pilot trial

Abstract BACKGROUND: Individuals who survive acute respiratory distress syndrome (ARDS) often face prolonged cognitive impairments. Comparable consequences have been observed in chronic hypoxic conditions, like COPD and obstructive sleep apnea..

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Association between preoperative hydration and cardiac surgery-associated acute kidney injury: a prospective observational study

Abstract Background Cardiac surgery associated acute kidney injury (CSA-AKI) is a common and serious complication following cardiac surgery with cardiopulmonary bypass (CPB), associated with prolonged hospitalization, increased costs, and higher..

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A Structured Checklist for Bedside Rounds on Extracorporeal Membrane Oxygenation Patients

Abstract Patients supported with extracorporeal membrane oxygenation (ECMO) represent a uniquely challenging population. These patients require specific interventions, such as repeated circuit and lower extremity perfusion assessments, anticoagulation management, frequent..

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Revolutionizing Accelerated Percutaneous Initiation and Deployment of ECPR (RAPID ECPR): Single-Center Process and Outcomes

Abstract Objectives Recent randomized controlled trials comparing extracorporeal cardiopulmonary resuscitation (ECPR) with conventional cardiopulmonary resuscitation (CCPR) reveal mixed outcomes; however, current data support an association between ECPR and neurologically intact..

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Postoperative Hematocrit and Lactate Trajectory After Neonatal Cardiopulmonary Bypass: A Retrospective Cohort Study

Abstract Lactate clearance is a key marker of oxygen delivery after neonatal cardiac surgery. While higher hematocrit (HCT) is often targeted to optimize oxygen delivery, its relationship with postoperative lactate..

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Awake paediatric venovenous extracorporeal membrane oxygenation case report: Feasibility of PICUStars Liberation Bundles to achieve early mobilisation

Abstract Awake extracorporeal membrane oxygenation (aECMO) has emerged as a strategy to minimise physical and neurocognitive complications of a prolonged intensive care admission. However, the safety and implementation in critically..

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How to monitor and manage unfractionated heparin in practice (Part 1)? Guidance from the SSC of the ISTH

Abstract The International Society on Thrombosis and Haemostasis (ISTH) recently published a survey on the management of unfractionated heparin (UFH), which revealed substantial heterogeneity in practice and highlighted the need..

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Is Preoperative Serum Bicarbonate an Undervalued Risk Factor in Cardiac Surgery?

Abstract Existing risk stratification methods in cardiothoracic surgery do not use pre-operative bicarbonate levels. We investigate if these levels carry predictive value when compared with demographic, hematologic, and other renal..

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