Perfusfind S.L.
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From Pandemic to Practice: How COVID-19 Has Reshaped Haemostasis in Cardiac Surgery: A Narrative Review

Abstract The utilisation of cardiopulmonary bypass (CPB) during cardiac surgery is often associated with complex haemostatic perturbations, frequently manifesting as a paradoxical risk of both bleeding and thrombosis. This is..

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Performance of Supervised Machine Learning Models for Cardiac Surgery-Associated Acute Kidney Injury in Children: Multicenter Retrospective Cohort Study, 2019–2022

Abstract Objectives:  To derive and externally validate supervised machine learning (ML) models predictive of cardiac surgery-associated acute kidney injury (CS-AKI). Design:  Retrospective cohort analysis. Setting:  Multicenter (4), cardiac surgical centers..

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Forged in conflict: how wars and crises shaped cardiovascular surgery

Abstract Wars and crises have historically acted as powerful catalysts for advances in cardiovascular surgery. Throughout the twentieth and twenty-first centuries, periods of armed conflict and global emergencies have driven..

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Is bedside empiricism the genuine gold standard of daily clinical practice? Rethinking evidence in extracorporeal care and perfusion

Abstract In extracorporeal life support and perfusion, progress has rarely followed the neat, linear hierarchy of evidence promoted by traditional evidence-based medicine. The randomized controlled trial (RCT) remains the proclaimed..

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Total Intravenous Versus Volatile Anesthesia in Pediatric Cardiac Surgery: Inflammatory Response and Early Recovery Profiles

Abstract Objectives To compare the effects of total intravenous anesthesia (TIVA) versus volatile anesthesia on systemic inflammation and early postoperative cognitive recovery in pediatric patients undergoing cardiac surgery with cardiopulmonary..

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Management of cardiopulmonary bypass in children with hypoplastic left heart syndrome undergoing multiple sternotomy procedures: a case report

Abstract Background: Hypoplastic left heart syndrome (HLHS) is a severe and complex congenital heart defect characterized by the underdevelopment of the left-sided cardiac structures. Management of HLHS typically involves multiple staged..

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Preservation of Platelet Function After Intraoperative Cell Salvage Using the i-SEP Same Device in Cardiac Surgery

Abstract Objectives To evaluate whether platelet function is preserved after intraoperative autotransfusion using the Same system, a device designed to retain both red blood cells and platelets in patients undergoing..

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Persistent Critical Illness After Cardiac Surgery: Prevalence, Characteristics, Trajectory, Outcomes, and Predictive Scores

Abstract Aim To determine the prevalence of persistent critical illness (PerCI) after cardiac surgery, describe the characteristics, trajectory, and outcomes of these patients, identify risk factors, and develop predictive risk..

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Weathering the Aorta: The Impact of Environmental Factors on Acute Aortic Dissection

Abstract Objectives Acute type A aortic dissection is a life-threatening condition with evidence suggesting a role for environmental triggers, particularly cold exposure. However, the impact of subjective, or derived thermal..

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Beyond Standard Parameters: Precision Hemodynamic Monitoring in Patients on Veno-Arterial ECMO

Abstract Background: Hemodynamic management in veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is inherently complex, as extracorporeal circulation profoundly alters preload, afterload, ventriculo-arterial coupling and tissue perfusion. This review summarizes current..

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Anticoagulation and hemostasis in the extracorporeal membrane oxygenation patient

Abstract Purpose of review  To provide an updated overview of hemostatic disturbances and anticoagulation management during extracorporeal membrane oxygenation (ECMO), emphasizing the mechanisms underlying the dual risk of bleeding and..

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Time from mechanical ventilation initiation to venovenous extracorporeal membrane oxygenation in COVID-19: A prospective, multicentre, observational study

Abstract Background The impact of the duration of invasive mechanical ventilation (IMV) before venovenous extracorporeal membrane oxygenation (VV ECMO) on patient outcomes in COVID-19 remains unclear. Methods and setting Data..

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Blood Prime Of The Cardiopulmonary Bypass Circuit In Congenital Heart Surgery

Abstract Introduction: The use of cardiopulmonary bypass (CPB) is necessary during the repair of most congenital heart disease (CHD). The surface area of the CPB circuit and the volume of..

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Levosimendan to Facilitate Weaning From ECMO in Patients With Severe Cardiogenic Shock

Abstract Importance  Levosimendan may facilitate weaning from venoarterial extracorporeal membrane oxygenation (VA-ECMO) and improve survival, but supporting evidence remains limited. Objective  To assess whether early administration of levosimendan reduces the time to..

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Extracorporeal Cardiopulmonary Resuscitation in Cardiac Arrest Associated to Neuroleptic Malignant Syndrome: A Case Report

Abstract Neuroleptic malignant syndrome (NMS) is a rare, life-threatening hypermetabolic reaction to dopamine-antagonist drugs that may progress to profound rhabdomyolysis, extreme hyperkalemia, and cardiac arrest (CA). Evidence guiding extracorporeal cardiopulmonary..

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Extracorporeal Membrane Oxygenation for Acute Respiratory Failure in a Dog

Abstract Extracorporeal membrane oxygenation (ECMO), a specialized medical technology that temporarily assumes the function of the heart and lungs, allows the body time to recover from severe respiratory failure. Although..

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Continuous EEG Monitoring and Clinical Outcomes in Patients Undergoing ECMO

Abstract Background Neurological complications during Extracorporeal membrane oxygenation (ECMO) can result in long-term cognitive deficits. This exploratory study aimed to determine the association between continuous EEG (cEEG) findings and neurological..

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A Comparative Analysis of Bivalirudin and Heparin for Extracorporeal Membrane Oxygenation in a Pediatric Cardiothoracic Intensive Care Unit

Abstract Unfractionated heparin has long been the conventional anticoagulant for pediatric mechanical circulatory support (MCS). As bivalirudin has gained traction in ventricular assist devices (VAD) management, its role in extracorporeal..

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Tissue Oxygen Saturation Combined With Serum Lactic Acid Can Predict Cardiac Surgery–Associated Acute Kidney Injury

Abstract Objectives To investigate the potential contribution of tissue oxygenation prediction in cardiac surgery–associated acute kidney injury (CSA-AKI) using near-infrared spectroscopy (NIRS) and serum lactate level measurements. Design A retrospective..

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Evaluating the performance of the NarcotrendR EEG index during anaesthesia for cardiothoracic surgery: a single-centre retrospective study

Abstract Background Using neuromonitoring during general anaesthesia provides insights into the effects of anaesthetics on the brain. We focus on the performance of the processed EEG indices NarcotrendR (NCT) and Burst..

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Heart and Lung Procurement and Transplantation

  Algorithmic Step-by-Step Technique for Combined Heart and Lung Procurement Technique of Dr. Sam Zeraatiannejaddavani, MD ⸻ I. Fundamental Principles Combined heart and lung procurement is a physiology-driven, time-sensitive operation..

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LV unloading in VA ECMO: Story from real cases

  Faten Farid Awdallah:   Critical care consultants at king Abdullah medical city, holly capital. Critical care ass professor at national heart institute, Egypt

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Predictive Markers of Neurological Complications in Patients Treated With Extracorporeal Membrane Oxygenation

Abstract Critically ill patients rescued with extracorporeal membrane oxygenation (ECMO) are at risk for devastating complications, including stroke and intracerebral hemorrhage (ICH). Despite an appreciation of some clinical risk factors, we..

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Weaning from venovenous extracorporeal membrane oxygenation for acute respiratory failure: challenges and opportunities

Abstract Purpose of review  The process of weaning from venovenous extracorporeal membrane oxygenation (V-V ECMO) is a critical step in the recovery of patients with severe acute respiratory distress syndrome..

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Single-cell immune landscape of acute kidney injury after cardiac surgery with cardiopulmonary bypass

Abstract Objectives Acute kidney injury (AKI) occurs in 19–42% of patients with cardiac surgery under cardiopulmonary bypass (CPB). Clarifying their landscape of immune cells may help discover the mechanisms and..

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Association between hyperoxia and mortality in patients undergoing extracorporeal membrane oxygenation: A systematic review and meta-analysis

Abstract Background The Association between hyperoxia and mortality in patients receiving extracorporeal membrane oxygenation (ECMO) remains controversial. This study aimed to systematically evaluate the impact of arterial hyperoxia on mortality..

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Alternate functions of physiological anticoagulants

Abstract The anticoagulant proteins antithrombin, protein C, protein S, and tissue factor pathway inhibitor are physiological regulators of the blood coagulation pathway and have complex roles in causing or modifying..

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Effects of platelet transfusions on neonatal bleeding and inflammation

Abstract Background Platelet transfusions are frequently given to preterm neonates. However, observational and randomized studies have reported higher morbidity and mortality associated with increased numbers of transfusions. We hypothesized that..

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Axillary Versus Femoral Artery Cannulation in Type A Aortic Dissection: A Systematic Review and Meta-Analysis

Abstract Acute type A aortic dissection is a life-threatening condition requiring immediate surgical intervention. However, the optimal arterial cannulation site for cardiopulmonary bypass during surgery remains a subject of debate...

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Comparing fluid dynamics of newborn and adult centrifugal pumps in cardiopulmonary bypass procedures

Abstract Background Cardiopulmonary bypass (CPB) plays a crucial role in cardiac surgery, with the pump being a key component affecting both hemolysis and thrombosis. Centrifugal levitating pumps (CP) have demonstrated..

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